The Role of Trophoblast Interferons in the Maintenance of Early Pregnancy in Ruminants
PROBLEM: Are the effects of ruminant trophoblast interferon‐tau (IFN‐τ) on uterine prostaglandin (PG) secretion a specific action of this cytokine and what are the effects of IFN‐τ on expression of uterine genes not generally associated with pregnancy maintenance? METHODS: The effects of IFN‐τ and I...
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 1997-01, Vol.37 (1), p.137-143 |
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| container_title | American journal of reproductive immunology (1989) |
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| creator | Godkin, James D. Smith, Scott E. Johnson, Roger D. Doré, Jules J.E. |
| description | PROBLEM: Are the effects of ruminant trophoblast interferon‐tau (IFN‐τ) on uterine prostaglandin (PG) secretion a specific action of this cytokine and what are the effects of IFN‐τ on expression of uterine genes not generally associated with pregnancy maintenance?
METHODS: The effects of IFN‐τ and IFN‐α on bovine uterine expiant and epithelial cell production of PGF2α and PGE2 were determined in the presence and absence of oxytocin (OT). The effects of intrauterine administration of IFN‐τ were determined on uterine expression of retinol‐binding protein (RBP) and transforming growth factor‐beta (TGF‐β) isoforms.
RESULTS: IFN‐τ attenuated uterine endometrial secretion of PGF2α and PGE2 in vitro and diminish PG stimulation by OT. IFN‐τ and IFN‐α were observed to be equipotent. Intrauterine infusion of IFN‐τ resulted in a significant decrease in steady‐state RBP mRNA levels and expression of TGF‐B1, 2, and 3 mRNA levels were lowest in IFN‐τ treated animals.
CONCLUSION: Negative regulation of gene expression may be a general strategy in IFN activity. This may explain the similar activities of IFN‐τ and IFN‐α on a broad variety of cell types, including ruminant uterine endometrium. |
| doi_str_mv | 10.1111/j.1600-0897.1997.tb00202.x |
| format | Article |
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METHODS: The effects of IFN‐τ and IFN‐α on bovine uterine expiant and epithelial cell production of PGF2α and PGE2 were determined in the presence and absence of oxytocin (OT). The effects of intrauterine administration of IFN‐τ were determined on uterine expression of retinol‐binding protein (RBP) and transforming growth factor‐beta (TGF‐β) isoforms.
RESULTS: IFN‐τ attenuated uterine endometrial secretion of PGF2α and PGE2 in vitro and diminish PG stimulation by OT. IFN‐τ and IFN‐α were observed to be equipotent. Intrauterine infusion of IFN‐τ resulted in a significant decrease in steady‐state RBP mRNA levels and expression of TGF‐B1, 2, and 3 mRNA levels were lowest in IFN‐τ treated animals.
CONCLUSION: Negative regulation of gene expression may be a general strategy in IFN activity. This may explain the similar activities of IFN‐τ and IFN‐α on a broad variety of cell types, including ruminant uterine endometrium.</description><identifier>ISSN: 1046-7408</identifier><identifier>ISSN: 8755-8920</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/j.1600-0897.1997.tb00202.x</identifier><identifier>PMID: 9138447</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cattle ; Dinoprost - biosynthesis ; Dinoprostone - biosynthesis ; Embryo Implantation - immunology ; Endometrium - drug effects ; Endometrium - metabolism ; Female ; Fetal-maternal interactions ; Fundamental and applied biological sciences. Psychology ; Interferon Type I ; Interferon-alpha - physiology ; Interferon-gamma - physiology ; interferons ; luteal maintenance ; Mother. Fetoplacental unit. Mammary gland. Milk ; pregnancy maintenance ; Pregnancy Proteins - physiology ; Pregnancy. Parturition. Lactation ; Retinol-Binding Proteins - analysis ; Sheep ; Transforming Growth Factor beta - analysis ; trophoblast ; Trophoblasts - metabolism ; uterus ; Vertebrates: reproduction</subject><ispartof>American journal of reproductive immunology (1989), 1997-01, Vol.37 (1), p.137-143</ispartof><rights>1997 Munksgaard</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5332-ebeaa979abf2e67ce879ee1977d7aad36c219cb44781adf99852f7189bc4181d3</citedby><cites>FETCH-LOGICAL-c5332-ebeaa979abf2e67ce879ee1977d7aad36c219cb44781adf99852f7189bc4181d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0897.1997.tb00202.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0897.1997.tb00202.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,1411,4036,4037,23909,23910,25118,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2576269$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9138447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Godkin, James D.</creatorcontrib><creatorcontrib>Smith, Scott E.</creatorcontrib><creatorcontrib>Johnson, Roger D.</creatorcontrib><creatorcontrib>Doré, Jules J.E.</creatorcontrib><title>The Role of Trophoblast Interferons in the Maintenance of Early Pregnancy in Ruminants</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>PROBLEM: Are the effects of ruminant trophoblast interferon‐tau (IFN‐τ) on uterine prostaglandin (PG) secretion a specific action of this cytokine and what are the effects of IFN‐τ on expression of uterine genes not generally associated with pregnancy maintenance?
METHODS: The effects of IFN‐τ and IFN‐α on bovine uterine expiant and epithelial cell production of PGF2α and PGE2 were determined in the presence and absence of oxytocin (OT). The effects of intrauterine administration of IFN‐τ were determined on uterine expression of retinol‐binding protein (RBP) and transforming growth factor‐beta (TGF‐β) isoforms.
RESULTS: IFN‐τ attenuated uterine endometrial secretion of PGF2α and PGE2 in vitro and diminish PG stimulation by OT. IFN‐τ and IFN‐α were observed to be equipotent. Intrauterine infusion of IFN‐τ resulted in a significant decrease in steady‐state RBP mRNA levels and expression of TGF‐B1, 2, and 3 mRNA levels were lowest in IFN‐τ treated animals.
CONCLUSION: Negative regulation of gene expression may be a general strategy in IFN activity. This may explain the similar activities of IFN‐τ and IFN‐α on a broad variety of cell types, including ruminant uterine endometrium.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Dinoprost - biosynthesis</subject><subject>Dinoprostone - biosynthesis</subject><subject>Embryo Implantation - immunology</subject><subject>Endometrium - drug effects</subject><subject>Endometrium - metabolism</subject><subject>Female</subject><subject>Fetal-maternal interactions</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Interferon Type I</subject><subject>Interferon-alpha - physiology</subject><subject>Interferon-gamma - physiology</subject><subject>interferons</subject><subject>luteal maintenance</subject><subject>Mother. Fetoplacental unit. Mammary gland. Milk</subject><subject>pregnancy maintenance</subject><subject>Pregnancy Proteins - physiology</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Retinol-Binding Proteins - analysis</subject><subject>Sheep</subject><subject>Transforming Growth Factor beta - analysis</subject><subject>trophoblast</subject><subject>Trophoblasts - metabolism</subject><subject>uterus</subject><subject>Vertebrates: reproduction</subject><issn>1046-7408</issn><issn>8755-8920</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkNtO4zAQhi3EqkDZR0CKEOIuXR8SH7hAqhCHrmAXVV24tBxnAilpUuxUtG-Ps416i_CFPZ755p_Rj9ApwSMSzq_5iHCMYyyVGBEVrjbDmGI6Wu-hw11pP8Q44bFIsDxAR97PMQ55JgZooAiTSSIO0dPsFaJpU0HUFNHMNcvXJquMb6NJ3YIrwDW1j8o6agP2YMqQrE1t_9PXxlWb6NHBS5fadNR0tSjDp_XH6EdhKg8_-3eI_t1cz67u4vu_t5Or8X1sU8ZoDBkYo4QyWUGBCwtSKACihMiFMTnjlhJls7CpJCYvlJIpLQSRKrMJkSRnQ3S-1V265n0FvtWL0luoKlNDs_JaSJnyhOMvQZIqzjHhAbzYgtY13jso9NKVC-M2mmDdua_nurNYdxbrzn3du6_Xofmkn7LKFpDvWnu7Q_2srxtvTVW4YFzpdxhNBadcBexyi32UFWy-sYAe_56EIAjEW4HSt7DeCRj3prlgItXPf261fJoyymZTLdkn_9WwgQ</recordid><startdate>199701</startdate><enddate>199701</enddate><creator>Godkin, James D.</creator><creator>Smith, Scott E.</creator><creator>Johnson, Roger D.</creator><creator>Doré, Jules J.E.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>199701</creationdate><title>The Role of Trophoblast Interferons in the Maintenance of Early Pregnancy in Ruminants</title><author>Godkin, James D. ; Smith, Scott E. ; Johnson, Roger D. ; Doré, Jules J.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5332-ebeaa979abf2e67ce879ee1977d7aad36c219cb44781adf99852f7189bc4181d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Dinoprost - biosynthesis</topic><topic>Dinoprostone - biosynthesis</topic><topic>Embryo Implantation - immunology</topic><topic>Endometrium - drug effects</topic><topic>Endometrium - metabolism</topic><topic>Female</topic><topic>Fetal-maternal interactions</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Interferon Type I</topic><topic>Interferon-alpha - physiology</topic><topic>Interferon-gamma - physiology</topic><topic>interferons</topic><topic>luteal maintenance</topic><topic>Mother. Fetoplacental unit. Mammary gland. Milk</topic><topic>pregnancy maintenance</topic><topic>Pregnancy Proteins - physiology</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Retinol-Binding Proteins - analysis</topic><topic>Sheep</topic><topic>Transforming Growth Factor beta - analysis</topic><topic>trophoblast</topic><topic>Trophoblasts - metabolism</topic><topic>uterus</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Godkin, James D.</creatorcontrib><creatorcontrib>Smith, Scott E.</creatorcontrib><creatorcontrib>Johnson, Roger D.</creatorcontrib><creatorcontrib>Doré, Jules J.E.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Godkin, James D.</au><au>Smith, Scott E.</au><au>Johnson, Roger D.</au><au>Doré, Jules J.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Trophoblast Interferons in the Maintenance of Early Pregnancy in Ruminants</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>1997-01</date><risdate>1997</risdate><volume>37</volume><issue>1</issue><spage>137</spage><epage>143</epage><pages>137-143</pages><issn>1046-7408</issn><issn>8755-8920</issn><eissn>1600-0897</eissn><abstract>PROBLEM: Are the effects of ruminant trophoblast interferon‐tau (IFN‐τ) on uterine prostaglandin (PG) secretion a specific action of this cytokine and what are the effects of IFN‐τ on expression of uterine genes not generally associated with pregnancy maintenance?
METHODS: The effects of IFN‐τ and IFN‐α on bovine uterine expiant and epithelial cell production of PGF2α and PGE2 were determined in the presence and absence of oxytocin (OT). The effects of intrauterine administration of IFN‐τ were determined on uterine expression of retinol‐binding protein (RBP) and transforming growth factor‐beta (TGF‐β) isoforms.
RESULTS: IFN‐τ attenuated uterine endometrial secretion of PGF2α and PGE2 in vitro and diminish PG stimulation by OT. IFN‐τ and IFN‐α were observed to be equipotent. Intrauterine infusion of IFN‐τ resulted in a significant decrease in steady‐state RBP mRNA levels and expression of TGF‐B1, 2, and 3 mRNA levels were lowest in IFN‐τ treated animals.
CONCLUSION: Negative regulation of gene expression may be a general strategy in IFN activity. This may explain the similar activities of IFN‐τ and IFN‐α on a broad variety of cell types, including ruminant uterine endometrium.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9138447</pmid><doi>10.1111/j.1600-0897.1997.tb00202.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | American journal of reproductive immunology (1989), 1997-01, Vol.37 (1), p.137-143 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biological and medical sciences Cattle Dinoprost - biosynthesis Dinoprostone - biosynthesis Embryo Implantation - immunology Endometrium - drug effects Endometrium - metabolism Female Fetal-maternal interactions Fundamental and applied biological sciences. Psychology Interferon Type I Interferon-alpha - physiology Interferon-gamma - physiology interferons luteal maintenance Mother. Fetoplacental unit. Mammary gland. Milk pregnancy maintenance Pregnancy Proteins - physiology Pregnancy. Parturition. Lactation Retinol-Binding Proteins - analysis Sheep Transforming Growth Factor beta - analysis trophoblast Trophoblasts - metabolism uterus Vertebrates: reproduction |
| title | The Role of Trophoblast Interferons in the Maintenance of Early Pregnancy in Ruminants |
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