Folate receptors as potential therapeutic targets in choroid plexus tumors of SV40 transgenic mice

A high affinity folate receptor is expressed in some human cancers, including choroid plexus tumors and ependymomas, and has been suggested as a target for therapeutics. In this report, the expression of folate receptors in an SV40 large T antigen transgenic mouse (SV11) was investigated. SV11 mice...

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Veröffentlicht in:	Journal of neuro-oncology 1997-04, Vol.32 (2), p.111-123
Hauptverfasser:	PATRICK, T. A, KRANZ, D. M, VAN DYKE, T. A, ROY, E. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Animals Antigens, Polyomavirus Transforming - genetics Autoradiography Biological and medical sciences Blood-Brain Barrier Brain - anatomy & histology Brain - metabolism Brain cancer Carrier Proteins - genetics Carrier Proteins - metabolism Choroid plexus Choroid Plexus Neoplasms - genetics Choroid Plexus Neoplasms - metabolism Ependymoma - genetics Ependymoma - metabolism Folate Receptors, GPI-Anchored Folic acid Immunohistochemistry Isoforms Male Medical sciences Mice Mice, Transgenic Molecular weight Neurology Parenchyma Polymerase Chain Reaction Receptors, Cell Surface Therapeutic applications Therapeutic targets Transgenic animals Transgenic mice Tumor Cells, Cultured - metabolism Tumors Tumors of the nervous system. Phacomatoses Vitamin B
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