The frequency of pulsatile luteinizing hormone-releasing hormone treatment and luteinizing hormone and follicle-stimulating hormone secretion in women with amenorrhea of suprapituitary origin
The influence of luteinizing hormone-releasing hormone (LH-RH) pulse frequency on luteinizing hormone (LH) and follicle-stimulating hormone (FSH) was studied in hypogonadotropic hypogonadal women. They received three regimens of 5 days of pulsatile LH-RH (5 μg/pulse) given at 30-, 90-, or 180-minute...
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| Veröffentlicht in: | Fertility and sterility 1989-03, Vol.51 (3), p.416-422 |
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| container_title | Fertility and sterility |
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| creator | Lambalk, Cornells B. Schoemaker, Joop Peter van Rees, G. van Dieten, Hannie A.M.J. |
| description | The influence of luteinizing hormone-releasing hormone (LH-RH) pulse frequency on luteinizing hormone (LH) and follicle-stimulating hormone (FSH) was studied in hypogonadotropic hypogonadal women. They received three regimens of 5 days of pulsatile LH-RH (5 μg/pulse) given at 30-, 90-, or 180-minute intervals, with at least 6 weeks between treatments. On day 1, LH and FSH increased in proportion to the LH-RH pulse frequency. After 5 days of treatment with the 30- and 90-minute intervals, LH was still elevated, but FSH had returned to pretreatment levels together with a decline of the FSH response. The LH response only declined during treatment with the 30-minute pulse interval. During each treatment, estradiol (E2) increased. Explanations for dissociation between LH and FSH secretion during treatment with higher LH-RH pulse frequencies could be: (1) desensitization of FSH rather than LH secretion on LH-RH; (2) a differential effect of E2 on LH and FSH; (3) nonsteroidal ovarian factors selectively regulating LH and/or FSH release. |
| doi_str_mv | 10.1016/S0015-0282(16)60546-0 |
| format | Article |
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They received three regimens of 5 days of pulsatile LH-RH (5 μg/pulse) given at 30-, 90-, or 180-minute intervals, with at least 6 weeks between treatments. On day 1, LH and FSH increased in proportion to the LH-RH pulse frequency. After 5 days of treatment with the 30- and 90-minute intervals, LH was still elevated, but FSH had returned to pretreatment levels together with a decline of the FSH response. The LH response only declined during treatment with the 30-minute pulse interval. During each treatment, estradiol (E2) increased. Explanations for dissociation between LH and FSH secretion during treatment with higher LH-RH pulse frequencies could be: (1) desensitization of FSH rather than LH secretion on LH-RH; (2) a differential effect of E2 on LH and FSH; (3) nonsteroidal ovarian factors selectively regulating LH and/or FSH release.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)60546-0</identifier><identifier>PMID: 2493401</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Amenorrhea - drug therapy ; Amenorrhea - metabolism ; Estradiol - blood ; Female ; Follicle Stimulating Hormone - blood ; Follicle Stimulating Hormone - secretion ; Gonadotropin-Releasing Hormone - administration & dosage ; Humans ; Infusion Pumps ; Infusions, Intravenous ; Luteinizing Hormone - blood ; Luteinizing Hormone - secretion ; Pulsatile Flow</subject><ispartof>Fertility and sterility, 1989-03, Vol.51 (3), p.416-422</ispartof><rights>1989 American Society for Reproductive Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-1272a7cd8ba15625dc406c819eb27d610d9ff61b36711863936417341a3c188a3</citedby><cites>FETCH-LOGICAL-c360t-1272a7cd8ba15625dc406c819eb27d610d9ff61b36711863936417341a3c188a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028216605460$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2493401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lambalk, Cornells B.</creatorcontrib><creatorcontrib>Schoemaker, Joop</creatorcontrib><creatorcontrib>Peter van Rees, G.</creatorcontrib><creatorcontrib>van Dieten, Hannie A.M.J.</creatorcontrib><title>The frequency of pulsatile luteinizing hormone-releasing hormone treatment and luteinizing hormone and follicle-stimulating hormone secretion in women with amenorrhea of suprapituitary origin</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>The influence of luteinizing hormone-releasing hormone (LH-RH) pulse frequency on luteinizing hormone (LH) and follicle-stimulating hormone (FSH) was studied in hypogonadotropic hypogonadal women. They received three regimens of 5 days of pulsatile LH-RH (5 μg/pulse) given at 30-, 90-, or 180-minute intervals, with at least 6 weeks between treatments. On day 1, LH and FSH increased in proportion to the LH-RH pulse frequency. After 5 days of treatment with the 30- and 90-minute intervals, LH was still elevated, but FSH had returned to pretreatment levels together with a decline of the FSH response. The LH response only declined during treatment with the 30-minute pulse interval. During each treatment, estradiol (E2) increased. Explanations for dissociation between LH and FSH secretion during treatment with higher LH-RH pulse frequencies could be: (1) desensitization of FSH rather than LH secretion on LH-RH; (2) a differential effect of E2 on LH and FSH; (3) nonsteroidal ovarian factors selectively regulating LH and/or FSH release.</description><subject>Adult</subject><subject>Amenorrhea - drug therapy</subject><subject>Amenorrhea - metabolism</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - blood</subject><subject>Follicle Stimulating Hormone - secretion</subject><subject>Gonadotropin-Releasing Hormone - administration & dosage</subject><subject>Humans</subject><subject>Infusion Pumps</subject><subject>Infusions, Intravenous</subject><subject>Luteinizing Hormone - blood</subject><subject>Luteinizing Hormone - secretion</subject><subject>Pulsatile Flow</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctuFDEQtBAoLIFPiOQTgsOAezz2zJ4QinhJkTgQzpbX05Nt5LEX25MIfo5fw_tQlAMSJ9vdVV3VLsYuQLwBAfrtNyFANaId2legX2uhOt2IR2wFSulGaSUfs9U95Cl7lvMPIYSGvj1jZ223lp2AFftzvUU-Jfy5YHC_eJz4bvHZFvLI_VKQAv2mcMO3Mc0xYJPQo80PKrwktGXGULgN4784h_oUvSfnscmF5sVXgQeAjC5hoRg4BX4X6zB-R2XLbb3FlLZo98byskt2R2WhYlO1muiGwnP2ZLI-44vTec6-f_xwffm5ufr66cvl-6vGSS1KA23f2t6Nw8aC0q0aXSe0G2CNm7YfNYhxPU0aNlL3AIOWa6k76GUHVjoYBivP2cvj3F2K9a9yMTNlh97bgHHJph8GpYUcKlAdgS7FnBNOZpdoroYNCLMPzhyCM_tUTH0dgjOi8i5OAstmxvGedUqq9t8d-1i3vCVMJjuqmeFICV0xY6T_KPwFon2t8A</recordid><startdate>19890301</startdate><enddate>19890301</enddate><creator>Lambalk, Cornells B.</creator><creator>Schoemaker, Joop</creator><creator>Peter van Rees, G.</creator><creator>van Dieten, Hannie A.M.J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890301</creationdate><title>The frequency of pulsatile luteinizing hormone-releasing hormone treatment and luteinizing hormone and follicle-stimulating hormone secretion in women with amenorrhea of suprapituitary origin</title><author>Lambalk, Cornells B. ; Schoemaker, Joop ; Peter van Rees, G. ; van Dieten, Hannie A.M.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-1272a7cd8ba15625dc406c819eb27d610d9ff61b36711863936417341a3c188a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Amenorrhea - drug therapy</topic><topic>Amenorrhea - metabolism</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - blood</topic><topic>Follicle Stimulating Hormone - secretion</topic><topic>Gonadotropin-Releasing Hormone - administration & dosage</topic><topic>Humans</topic><topic>Infusion Pumps</topic><topic>Infusions, Intravenous</topic><topic>Luteinizing Hormone - blood</topic><topic>Luteinizing Hormone - secretion</topic><topic>Pulsatile Flow</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lambalk, Cornells B.</creatorcontrib><creatorcontrib>Schoemaker, Joop</creatorcontrib><creatorcontrib>Peter van Rees, G.</creatorcontrib><creatorcontrib>van Dieten, Hannie A.M.J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lambalk, Cornells B.</au><au>Schoemaker, Joop</au><au>Peter van Rees, G.</au><au>van Dieten, Hannie A.M.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The frequency of pulsatile luteinizing hormone-releasing hormone treatment and luteinizing hormone and follicle-stimulating hormone secretion in women with amenorrhea of suprapituitary origin</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1989-03-01</date><risdate>1989</risdate><volume>51</volume><issue>3</issue><spage>416</spage><epage>422</epage><pages>416-422</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>The influence of luteinizing hormone-releasing hormone (LH-RH) pulse frequency on luteinizing hormone (LH) and follicle-stimulating hormone (FSH) was studied in hypogonadotropic hypogonadal women. They received three regimens of 5 days of pulsatile LH-RH (5 μg/pulse) given at 30-, 90-, or 180-minute intervals, with at least 6 weeks between treatments. On day 1, LH and FSH increased in proportion to the LH-RH pulse frequency. After 5 days of treatment with the 30- and 90-minute intervals, LH was still elevated, but FSH had returned to pretreatment levels together with a decline of the FSH response. The LH response only declined during treatment with the 30-minute pulse interval. During each treatment, estradiol (E2) increased. Explanations for dissociation between LH and FSH secretion during treatment with higher LH-RH pulse frequencies could be: (1) desensitization of FSH rather than LH secretion on LH-RH; (2) a differential effect of E2 on LH and FSH; (3) nonsteroidal ovarian factors selectively regulating LH and/or FSH release.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2493401</pmid><doi>10.1016/S0015-0282(16)60546-0</doi><tpages>7</tpages></addata></record> |
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| ispartof | Fertility and sterility, 1989-03, Vol.51 (3), p.416-422 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Amenorrhea - drug therapy Amenorrhea - metabolism Estradiol - blood Female Follicle Stimulating Hormone - blood Follicle Stimulating Hormone - secretion Gonadotropin-Releasing Hormone - administration & dosage Humans Infusion Pumps Infusions, Intravenous Luteinizing Hormone - blood Luteinizing Hormone - secretion Pulsatile Flow |
| title | The frequency of pulsatile luteinizing hormone-releasing hormone treatment and luteinizing hormone and follicle-stimulating hormone secretion in women with amenorrhea of suprapituitary origin |
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