Occipital Lobe Developmental Malformations and Epilepsy: Clinical Spectrum, Treatment, and Outcome
Purpose: Cortical developmental malformations (CDM) are increasingly recognized in association with epilepsy. We describe 10 patients (age range 14–35 years) with symptomatic occipital lobe epilepsy and CDM. Methods: Neurologic, neuroophthalmologic and electro‐physiologic studies were performed. Pat...
Gespeichert in:
| Veröffentlicht in: | Epilepsia (Copenhagen) 1997-02, Vol.38 (2), p.175-181 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 181 |
|---|---|
| container_issue | 2 |
| container_start_page | 175 |
| container_title | Epilepsia (Copenhagen) |
| container_volume | 38 |
| creator | Kuzniecky, Ruben Gilliam, Frank Morawetz, Richard Faught, Edward Palmer, Cheryl Black, Lorie |
| description | Purpose: Cortical developmental malformations (CDM) are increasingly recognized in association with epilepsy. We describe 10 patients (age range 14–35 years) with symptomatic occipital lobe epilepsy and CDM.
Methods: Neurologic, neuroophthalmologic and electro‐physiologic studies were performed. Patients had MRI, SPECT, and in some cases intracranial EEG investigators.
Results: Mean age of seizure onset was 8 years. We noted strong correlations between the presence of visual auras, the scalp EEG pattern, and the subtype of underlying pathology. Magnetic resonance imaging (MRI) showed CDM in all patients, with polymicrogyria and focal dysplasia being the most frequent malformations. Despite the presence of occipital lobe structural malformations in all patients, visual field deficits were present in only 2. Those who underwent cortical resections were seizure–free or showed major improvement at a mean follow–up of 3.5 years.
Conclusions: Intracranial stimulation studies and the low frequency of pre‐ and postoperative deficits suggest that some degree of cortical visual reorganization may occur in patients with occipital lobe malformations. Occipital lobe CDM should be sought as a cause of symptomatic occipital lobe epilepsy even though they may become symptomatic after childhood. |
| doi_str_mv | 10.1111/j.1528-1157.1997.tb01094.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78854779</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78854779</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5165-f61760d6c5cbf1cb75a9f8c7ef2f048e4e6211b9ac4b706e1e796e7e4bf08d303</originalsourceid><addsrcrecordid>eNqVkF1rFDEUhoNY6lr9CcIg0qvOmLMzSSa9EMq62sLKCtbrkGRPIMt8mcxo99-bcYfem5tA3ufNOTyEvAdaQDofjwWwdZ0DMFGAlKIYDQUqq-LpBVktERcvyYpSKHPJavqKvI7xSCkVXJSX5FLSquZcrojZW-sHP-om2_UGs8_4G5t-aLGbn77pxvWh1aPvu5jp7pBtB9_gEE-32abxnbcJ-jGgHcPU3mSPAfU4V2_-sftptH2Lb8iF003Et8t9RX5-2T5u7vPd_uvD5m6XWwac5Y6D4PTALbPGgTWCaelqK9CtXdoWK-RrACO1rYygHAGF5CiwMo7Wh5KWV-T6_O8Q-l8TxlG1PlpsGt1hP0Ul6ppVQsgE3p5BG_oYAzo1BN_qcFJA1SxYHdVsUc2C1SxYLYLVUyq_W6ZMpsXDc3UxmvIPS65jsuOC7qyPz9ia1SAET9inM_Yn-Tz9xwJq-_0BBCv_AkA9mPs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78854779</pqid></control><display><type>article</type><title>Occipital Lobe Developmental Malformations and Epilepsy: Clinical Spectrum, Treatment, and Outcome</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><source>Alma/SFX Local Collection</source><creator>Kuzniecky, Ruben ; Gilliam, Frank ; Morawetz, Richard ; Faught, Edward ; Palmer, Cheryl ; Black, Lorie</creator><creatorcontrib>Kuzniecky, Ruben ; Gilliam, Frank ; Morawetz, Richard ; Faught, Edward ; Palmer, Cheryl ; Black, Lorie</creatorcontrib><description>Purpose: Cortical developmental malformations (CDM) are increasingly recognized in association with epilepsy. We describe 10 patients (age range 14–35 years) with symptomatic occipital lobe epilepsy and CDM.
Methods: Neurologic, neuroophthalmologic and electro‐physiologic studies were performed. Patients had MRI, SPECT, and in some cases intracranial EEG investigators.
Results: Mean age of seizure onset was 8 years. We noted strong correlations between the presence of visual auras, the scalp EEG pattern, and the subtype of underlying pathology. Magnetic resonance imaging (MRI) showed CDM in all patients, with polymicrogyria and focal dysplasia being the most frequent malformations. Despite the presence of occipital lobe structural malformations in all patients, visual field deficits were present in only 2. Those who underwent cortical resections were seizure–free or showed major improvement at a mean follow–up of 3.5 years.
Conclusions: Intracranial stimulation studies and the low frequency of pre‐ and postoperative deficits suggest that some degree of cortical visual reorganization may occur in patients with occipital lobe malformations. Occipital lobe CDM should be sought as a cause of symptomatic occipital lobe epilepsy even though they may become symptomatic after childhood.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/j.1528-1157.1997.tb01094.x</identifier><identifier>PMID: 9048669</identifier><identifier>CODEN: EPILAK</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Age Factors ; Biological and medical sciences ; Developmental malformations ; Electric Stimulation ; Electrodes, Implanted ; Electroencephalography ; Epilepsy ; Epilepsy - diagnosis ; Epilepsy - drug therapy ; Epilepsy - physiopathology ; Female ; Follow-Up Studies ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurologic Examination ; Neurology ; Occipital lobe ; Occipital Lobe - abnormalities ; Occipital Lobe - physiopathology ; Occipital Lobe - surgery ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Epilepsia (Copenhagen), 1997-02, Vol.38 (2), p.175-181</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5165-f61760d6c5cbf1cb75a9f8c7ef2f048e4e6211b9ac4b706e1e796e7e4bf08d303</citedby><cites>FETCH-LOGICAL-c5165-f61760d6c5cbf1cb75a9f8c7ef2f048e4e6211b9ac4b706e1e796e7e4bf08d303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1528-1157.1997.tb01094.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1528-1157.1997.tb01094.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,1434,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2581776$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9048669$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuzniecky, Ruben</creatorcontrib><creatorcontrib>Gilliam, Frank</creatorcontrib><creatorcontrib>Morawetz, Richard</creatorcontrib><creatorcontrib>Faught, Edward</creatorcontrib><creatorcontrib>Palmer, Cheryl</creatorcontrib><creatorcontrib>Black, Lorie</creatorcontrib><title>Occipital Lobe Developmental Malformations and Epilepsy: Clinical Spectrum, Treatment, and Outcome</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Purpose: Cortical developmental malformations (CDM) are increasingly recognized in association with epilepsy. We describe 10 patients (age range 14–35 years) with symptomatic occipital lobe epilepsy and CDM.
Methods: Neurologic, neuroophthalmologic and electro‐physiologic studies were performed. Patients had MRI, SPECT, and in some cases intracranial EEG investigators.
Results: Mean age of seizure onset was 8 years. We noted strong correlations between the presence of visual auras, the scalp EEG pattern, and the subtype of underlying pathology. Magnetic resonance imaging (MRI) showed CDM in all patients, with polymicrogyria and focal dysplasia being the most frequent malformations. Despite the presence of occipital lobe structural malformations in all patients, visual field deficits were present in only 2. Those who underwent cortical resections were seizure–free or showed major improvement at a mean follow–up of 3.5 years.
Conclusions: Intracranial stimulation studies and the low frequency of pre‐ and postoperative deficits suggest that some degree of cortical visual reorganization may occur in patients with occipital lobe malformations. Occipital lobe CDM should be sought as a cause of symptomatic occipital lobe epilepsy even though they may become symptomatic after childhood.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Developmental malformations</subject><subject>Electric Stimulation</subject><subject>Electrodes, Implanted</subject><subject>Electroencephalography</subject><subject>Epilepsy</subject><subject>Epilepsy - diagnosis</subject><subject>Epilepsy - drug therapy</subject><subject>Epilepsy - physiopathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurologic Examination</subject><subject>Neurology</subject><subject>Occipital lobe</subject><subject>Occipital Lobe - abnormalities</subject><subject>Occipital Lobe - physiopathology</subject><subject>Occipital Lobe - surgery</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1rFDEUhoNY6lr9CcIg0qvOmLMzSSa9EMq62sLKCtbrkGRPIMt8mcxo99-bcYfem5tA3ufNOTyEvAdaQDofjwWwdZ0DMFGAlKIYDQUqq-LpBVktERcvyYpSKHPJavqKvI7xSCkVXJSX5FLSquZcrojZW-sHP-om2_UGs8_4G5t-aLGbn77pxvWh1aPvu5jp7pBtB9_gEE-32abxnbcJ-jGgHcPU3mSPAfU4V2_-sftptH2Lb8iF003Et8t9RX5-2T5u7vPd_uvD5m6XWwac5Y6D4PTALbPGgTWCaelqK9CtXdoWK-RrACO1rYygHAGF5CiwMo7Wh5KWV-T6_O8Q-l8TxlG1PlpsGt1hP0Ul6ppVQsgE3p5BG_oYAzo1BN_qcFJA1SxYHdVsUc2C1SxYLYLVUyq_W6ZMpsXDc3UxmvIPS65jsuOC7qyPz9ia1SAET9inM_Yn-Tz9xwJq-_0BBCv_AkA9mPs</recordid><startdate>199702</startdate><enddate>199702</enddate><creator>Kuzniecky, Ruben</creator><creator>Gilliam, Frank</creator><creator>Morawetz, Richard</creator><creator>Faught, Edward</creator><creator>Palmer, Cheryl</creator><creator>Black, Lorie</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199702</creationdate><title>Occipital Lobe Developmental Malformations and Epilepsy: Clinical Spectrum, Treatment, and Outcome</title><author>Kuzniecky, Ruben ; Gilliam, Frank ; Morawetz, Richard ; Faught, Edward ; Palmer, Cheryl ; Black, Lorie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5165-f61760d6c5cbf1cb75a9f8c7ef2f048e4e6211b9ac4b706e1e796e7e4bf08d303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>Developmental malformations</topic><topic>Electric Stimulation</topic><topic>Electrodes, Implanted</topic><topic>Electroencephalography</topic><topic>Epilepsy</topic><topic>Epilepsy - diagnosis</topic><topic>Epilepsy - drug therapy</topic><topic>Epilepsy - physiopathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurologic Examination</topic><topic>Neurology</topic><topic>Occipital lobe</topic><topic>Occipital Lobe - abnormalities</topic><topic>Occipital Lobe - physiopathology</topic><topic>Occipital Lobe - surgery</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuzniecky, Ruben</creatorcontrib><creatorcontrib>Gilliam, Frank</creatorcontrib><creatorcontrib>Morawetz, Richard</creatorcontrib><creatorcontrib>Faught, Edward</creatorcontrib><creatorcontrib>Palmer, Cheryl</creatorcontrib><creatorcontrib>Black, Lorie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuzniecky, Ruben</au><au>Gilliam, Frank</au><au>Morawetz, Richard</au><au>Faught, Edward</au><au>Palmer, Cheryl</au><au>Black, Lorie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Occipital Lobe Developmental Malformations and Epilepsy: Clinical Spectrum, Treatment, and Outcome</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>1997-02</date><risdate>1997</risdate><volume>38</volume><issue>2</issue><spage>175</spage><epage>181</epage><pages>175-181</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Purpose: Cortical developmental malformations (CDM) are increasingly recognized in association with epilepsy. We describe 10 patients (age range 14–35 years) with symptomatic occipital lobe epilepsy and CDM.
Methods: Neurologic, neuroophthalmologic and electro‐physiologic studies were performed. Patients had MRI, SPECT, and in some cases intracranial EEG investigators.
Results: Mean age of seizure onset was 8 years. We noted strong correlations between the presence of visual auras, the scalp EEG pattern, and the subtype of underlying pathology. Magnetic resonance imaging (MRI) showed CDM in all patients, with polymicrogyria and focal dysplasia being the most frequent malformations. Despite the presence of occipital lobe structural malformations in all patients, visual field deficits were present in only 2. Those who underwent cortical resections were seizure–free or showed major improvement at a mean follow–up of 3.5 years.
Conclusions: Intracranial stimulation studies and the low frequency of pre‐ and postoperative deficits suggest that some degree of cortical visual reorganization may occur in patients with occipital lobe malformations. Occipital lobe CDM should be sought as a cause of symptomatic occipital lobe epilepsy even though they may become symptomatic after childhood.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9048669</pmid><doi>10.1111/j.1528-1157.1997.tb01094.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0013-9580 |
| ispartof | Epilepsia (Copenhagen), 1997-02, Vol.38 (2), p.175-181 |
| issn | 0013-9580 1528-1167 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78854779 |
| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); Alma/SFX Local Collection |
| subjects | Adolescent Adult Age Factors Biological and medical sciences Developmental malformations Electric Stimulation Electrodes, Implanted Electroencephalography Epilepsy Epilepsy - diagnosis Epilepsy - drug therapy Epilepsy - physiopathology Female Follow-Up Studies Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Magnetic Resonance Imaging Male Medical sciences Nervous system (semeiology, syndromes) Neurologic Examination Neurology Occipital lobe Occipital Lobe - abnormalities Occipital Lobe - physiopathology Occipital Lobe - surgery Tomography, Emission-Computed, Single-Photon |
| title | Occipital Lobe Developmental Malformations and Epilepsy: Clinical Spectrum, Treatment, and Outcome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T00%3A01%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Occipital%20Lobe%20Developmental%20Malformations%20and%20Epilepsy:%20Clinical%20Spectrum,%20Treatment,%20and%20Outcome&rft.jtitle=Epilepsia%20(Copenhagen)&rft.au=Kuzniecky,%20Ruben&rft.date=1997-02&rft.volume=38&rft.issue=2&rft.spage=175&rft.epage=181&rft.pages=175-181&rft.issn=0013-9580&rft.eissn=1528-1167&rft.coden=EPILAK&rft_id=info:doi/10.1111/j.1528-1157.1997.tb01094.x&rft_dat=%3Cproquest_cross%3E78854779%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78854779&rft_id=info:pmid/9048669&rfr_iscdi=true |