Expression of Glutathione S-Transferase Activity and Glutathione Content in Squamous Cell Carcinoma of Bladder Associated with Schistosomiasis in a Population in Egypt
The present study was designed to describe the expression of the glutathione S-transferase/glutathione system in squamous cell carcinoma of the bladder in a population in Egypt. The glutathione-S transferase activity was significantly higher in bladder cancer specimens (n = 40) in comparison with sc...
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| Veröffentlicht in: | Scandinavian journal of urology and nephrology 1997, Vol.31 (1), p.43-47 |
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| container_title | Scandinavian journal of urology and nephrology |
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| creator | Ghazaly, Galal E. M. D. Zakahary, Madeha M. El-aziz, Mohamed A. A. Mahmoud, Ahmed A. E. M. Carretero, Pablo Lafuente, Amalia |
| description | The present study was designed to describe the expression of the glutathione S-transferase/glutathione system in squamous cell carcinoma of the bladder in a population in Egypt. The glutathione-S transferase activity was significantly higher in bladder cancer specimens (n = 40) in comparison with schistosomiasis cystitis tissue (n = 42) (4-fold, p = 1 × 10-12) and with healthy control samples (n = 9) (10-fold, p = 1 × 10-6). The glutathione content was also significantly higher in bladder cancer than in cystitis tissue (2-fold, p = 8 × 10-6) and in control samples (6-fold, 8 × 10-6). When control mucosa and cystitis samples were compared, 2-fold increased values were obtained for glutathione-S transferase (p = 4 × 10-3) and glutathione (p = 1 × 10-3) in schistosomiasis bladder tissue. Results describe an over-expression of glutathione-S transferase and glutathione levels in squamous cell carcinoma of the bladder, and indicate a possible role in chemoresistance to pharmacological therapy. |
| doi_str_mv | 10.3109/00365599709070301 |
| format | Article |
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M. D. ; Zakahary, Madeha M. ; El-aziz, Mohamed A. A. ; Mahmoud, Ahmed A. E. M. ; Carretero, Pablo ; Lafuente, Amalia</creator><creatorcontrib>Ghazaly, Galal E. M. D. ; Zakahary, Madeha M. ; El-aziz, Mohamed A. A. ; Mahmoud, Ahmed A. E. M. ; Carretero, Pablo ; Lafuente, Amalia</creatorcontrib><description>The present study was designed to describe the expression of the glutathione S-transferase/glutathione system in squamous cell carcinoma of the bladder in a population in Egypt. The glutathione-S transferase activity was significantly higher in bladder cancer specimens (n = 40) in comparison with schistosomiasis cystitis tissue (n = 42) (4-fold, p = 1 × 10-12) and with healthy control samples (n = 9) (10-fold, p = 1 × 10-6). The glutathione content was also significantly higher in bladder cancer than in cystitis tissue (2-fold, p = 8 × 10-6) and in control samples (6-fold, 8 × 10-6). When control mucosa and cystitis samples were compared, 2-fold increased values were obtained for glutathione-S transferase (p = 4 × 10-3) and glutathione (p = 1 × 10-3) in schistosomiasis bladder tissue. Results describe an over-expression of glutathione-S transferase and glutathione levels in squamous cell carcinoma of the bladder, and indicate a possible role in chemoresistance to pharmacological therapy.</description><identifier>ISSN: 0036-5599</identifier><identifier>EISSN: 1651-2065</identifier><identifier>DOI: 10.3109/00365599709070301</identifier><identifier>PMID: 9060083</identifier><identifier>CODEN: SJUNAS</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - pathology ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - pathology ; Drug Resistance, Neoplasm - genetics ; Egypt ; Female ; Gene Expression Regulation, Enzymologic - physiology ; glutathione ; Glutathione - metabolism ; glutathione S transferase ; Glutathione Transferase - genetics ; Humans ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; schistosomiasis ; Schistosomiasis haematobia - genetics ; Schistosomiasis haematobia - pathology ; squamous cell carcinoma ; Tumors of the urinary system ; Urinary Bladder - pathology ; Urinary Bladder Neoplasms - genetics ; Urinary Bladder Neoplasms - pathology ; Urinary tract. Prostate gland</subject><ispartof>Scandinavian journal of urology and nephrology, 1997, Vol.31 (1), p.43-47</ispartof><rights>1997 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1997</rights><rights>1997 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-d81e525b71ee291edd8fece439118b4cc4656adceb8b4647bedee7a8510c40a23</citedby><cites>FETCH-LOGICAL-c430t-d81e525b71ee291edd8fece439118b4cc4656adceb8b4647bedee7a8510c40a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365599709070301$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365599709070301$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2571151$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9060083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghazaly, Galal E. M. D.</creatorcontrib><creatorcontrib>Zakahary, Madeha M.</creatorcontrib><creatorcontrib>El-aziz, Mohamed A. A.</creatorcontrib><creatorcontrib>Mahmoud, Ahmed A. E. M.</creatorcontrib><creatorcontrib>Carretero, Pablo</creatorcontrib><creatorcontrib>Lafuente, Amalia</creatorcontrib><title>Expression of Glutathione S-Transferase Activity and Glutathione Content in Squamous Cell Carcinoma of Bladder Associated with Schistosomiasis in a Population in Egypt</title><title>Scandinavian journal of urology and nephrology</title><addtitle>Scand J Urol Nephrol</addtitle><description>The present study was designed to describe the expression of the glutathione S-transferase/glutathione system in squamous cell carcinoma of the bladder in a population in Egypt. The glutathione-S transferase activity was significantly higher in bladder cancer specimens (n = 40) in comparison with schistosomiasis cystitis tissue (n = 42) (4-fold, p = 1 × 10-12) and with healthy control samples (n = 9) (10-fold, p = 1 × 10-6). The glutathione content was also significantly higher in bladder cancer than in cystitis tissue (2-fold, p = 8 × 10-6) and in control samples (6-fold, 8 × 10-6). When control mucosa and cystitis samples were compared, 2-fold increased values were obtained for glutathione-S transferase (p = 4 × 10-3) and glutathione (p = 1 × 10-3) in schistosomiasis bladder tissue. Results describe an over-expression of glutathione-S transferase and glutathione levels in squamous cell carcinoma of the bladder, and indicate a possible role in chemoresistance to pharmacological therapy.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Drug Resistance, Neoplasm - genetics</subject><subject>Egypt</subject><subject>Female</subject><subject>Gene Expression Regulation, Enzymologic - physiology</subject><subject>glutathione</subject><subject>Glutathione - metabolism</subject><subject>glutathione S transferase</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>schistosomiasis</subject><subject>Schistosomiasis haematobia - genetics</subject><subject>Schistosomiasis haematobia - pathology</subject><subject>squamous cell carcinoma</subject><subject>Tumors of the urinary system</subject><subject>Urinary Bladder - pathology</subject><subject>Urinary Bladder Neoplasms - genetics</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>Urinary tract. Prostate gland</subject><issn>0036-5599</issn><issn>1651-2065</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UdGK1DAUDaKs4-oH-CDkQXyrJm2TtujLWMZVWFCY9bncJrc2S5t0k3TX-SJ_05YZFxZhny6He87hnnsIec3Z-4yz6gNjmRSiqgpWsYJljD8hGy4FT1ImxVOyWffJSnhOXoRwzRhLJZdn5KxikrEy25A_u9-TxxCMs9R19GKYI8R-QUj3yZUHGzr0EJBuVTS3Jh4oWP2AVjsb0UZqLN3fzDC6OdAah4HW4JWxboTV-PMAWqOn2xCcMhBR0zsTe7pXvQnRBTcaCCasLkB_uGkeIK43LXj36zDFl-RZB0PAV6d5Tn5-2V3VX5PL7xff6u1lovKMxUSXHEUq2oIjphVHrcsOFeZZxXnZ5krlUkjQCtsFybxoUSMWUArOVM4gzc7Ju6Pv5N3NjCE2owlqiQMWl2RNUZYiTwu5EPmRqLwLwWPXTN6M4A8NZ81aTvNfOYvmzcl8bkfU94pTG8v-7WkPQcHQLe9XJtzTUlFwLlabT0easZ3zI9w5P-gmwmFw_p8me-yKjw_kPcIQewUem2s3e7u895EMfwHurb_g</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Ghazaly, Galal E. M. D.</creator><creator>Zakahary, Madeha M.</creator><creator>El-aziz, Mohamed A. A.</creator><creator>Mahmoud, Ahmed A. E. M.</creator><creator>Carretero, Pablo</creator><creator>Lafuente, Amalia</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Expression of Glutathione S-Transferase Activity and Glutathione Content in Squamous Cell Carcinoma of Bladder Associated with Schistosomiasis in a Population in Egypt</title><author>Ghazaly, Galal E. M. D. ; Zakahary, Madeha M. ; El-aziz, Mohamed A. A. ; Mahmoud, Ahmed A. E. M. ; Carretero, Pablo ; Lafuente, Amalia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-d81e525b71ee291edd8fece439118b4cc4656adceb8b4647bedee7a8510c40a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Drug Resistance, Neoplasm - genetics</topic><topic>Egypt</topic><topic>Female</topic><topic>Gene Expression Regulation, Enzymologic - physiology</topic><topic>glutathione</topic><topic>Glutathione - metabolism</topic><topic>glutathione S transferase</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>schistosomiasis</topic><topic>Schistosomiasis haematobia - genetics</topic><topic>Schistosomiasis haematobia - pathology</topic><topic>squamous cell carcinoma</topic><topic>Tumors of the urinary system</topic><topic>Urinary Bladder - pathology</topic><topic>Urinary Bladder Neoplasms - genetics</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>Urinary tract. Prostate gland</topic><toplevel>online_resources</toplevel><creatorcontrib>Ghazaly, Galal E. M. D.</creatorcontrib><creatorcontrib>Zakahary, Madeha M.</creatorcontrib><creatorcontrib>El-aziz, Mohamed A. A.</creatorcontrib><creatorcontrib>Mahmoud, Ahmed A. E. 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M.</au><au>Carretero, Pablo</au><au>Lafuente, Amalia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Glutathione S-Transferase Activity and Glutathione Content in Squamous Cell Carcinoma of Bladder Associated with Schistosomiasis in a Population in Egypt</atitle><jtitle>Scandinavian journal of urology and nephrology</jtitle><addtitle>Scand J Urol Nephrol</addtitle><date>1997</date><risdate>1997</risdate><volume>31</volume><issue>1</issue><spage>43</spage><epage>47</epage><pages>43-47</pages><issn>0036-5599</issn><eissn>1651-2065</eissn><coden>SJUNAS</coden><abstract>The present study was designed to describe the expression of the glutathione S-transferase/glutathione system in squamous cell carcinoma of the bladder in a population in Egypt. The glutathione-S transferase activity was significantly higher in bladder cancer specimens (n = 40) in comparison with schistosomiasis cystitis tissue (n = 42) (4-fold, p = 1 × 10-12) and with healthy control samples (n = 9) (10-fold, p = 1 × 10-6). The glutathione content was also significantly higher in bladder cancer than in cystitis tissue (2-fold, p = 8 × 10-6) and in control samples (6-fold, 8 × 10-6). When control mucosa and cystitis samples were compared, 2-fold increased values were obtained for glutathione-S transferase (p = 4 × 10-3) and glutathione (p = 1 × 10-3) in schistosomiasis bladder tissue. Results describe an over-expression of glutathione-S transferase and glutathione levels in squamous cell carcinoma of the bladder, and indicate a possible role in chemoresistance to pharmacological therapy.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>9060083</pmid><doi>10.3109/00365599709070301</doi><tpages>5</tpages></addata></record> |
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| ispartof | Scandinavian journal of urology and nephrology, 1997, Vol.31 (1), p.43-47 |
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| source | Taylor & Francis:Master (3349 titles); MEDLINE; Taylor & Francis Medical Library - CRKN |
| subjects | Adult Aged Biological and medical sciences Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - pathology Drug Resistance, Neoplasm - genetics Egypt Female Gene Expression Regulation, Enzymologic - physiology glutathione Glutathione - metabolism glutathione S transferase Glutathione Transferase - genetics Humans Male Medical sciences Middle Aged Nephrology. Urinary tract diseases schistosomiasis Schistosomiasis haematobia - genetics Schistosomiasis haematobia - pathology squamous cell carcinoma Tumors of the urinary system Urinary Bladder - pathology Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology Urinary tract. Prostate gland |
| title | Expression of Glutathione S-Transferase Activity and Glutathione Content in Squamous Cell Carcinoma of Bladder Associated with Schistosomiasis in a Population in Egypt |
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