Cytosolic Ca2+ Regulation Attenuates ANP-Induced cGMP Response in Vascular Smooth Muscle Cells of the SHR

Cultured vascular smooth muscle cells (VSMCs) of the spontaneously hypertensive rat (SHR) show a higher density (Bmax) of ANP receptors and a blunted cyclic (c) GMP response to the hormone. To explore the idea that a higher cytosolic free Ca2+ (Cai2+) may be responsible for a blunted cGMP response t...

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