Executive function in multiple sclerosis: The role of frontal lobe pathology
Deficits in executive function and the relationship to frontal lesion load as detected on MRI were investigated in 42 multiple sclerosis patients. A battery of neuropsychological test examining executive skills including computerized tests of planning and spatial working memory was administered to a...
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| Veröffentlicht in: | Brain (London, England : 1878) England : 1878), 1997, Vol.120 (1), p.15-26 |
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| container_end_page | 26 |
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| container_title | Brain (London, England : 1878) |
| container_volume | 120 |
| creator | FOONG, J ROZEWICZ, L QUAGHEBEUR, G DAVIE, C. A KARTSOUNIS, L. D THOMPSON, A. J MILLER, D. H RON, M. A |
| description | Deficits in executive function and the relationship to frontal lesion load as detected on MRI were investigated in 42 multiple sclerosis patients. A battery of neuropsychological test examining executive skills including computerized tests of planning and spatial working memory was administered to all subjects. Performance on these tests was impaired in the patient group when compared with a group of matched controls, but not all executive skills were affected to the same extent. Although a number of executive test scores correlated with the severity of frontal lesion load, it was difficult to disentangle the specific contribution of frontal lobe pathology to the impairment on executive tasks. This study highlights the difficulties in attempting to attribute specific cognitive abnormalities to focal brain pathology in the presence of widespread disease such as in multiple sclerosis. |
| doi_str_mv | 10.1093/brain/120.1.15 |
| format | Article |
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This study highlights the difficulties in attempting to attribute specific cognitive abnormalities to focal brain pathology in the presence of widespread disease such as in multiple sclerosis.</description><identifier>ISSN: 0006-8950</identifier><identifier>ISSN: 1460-2156</identifier><identifier>EISSN: 1460-2156</identifier><identifier>DOI: 10.1093/brain/120.1.15</identifier><identifier>PMID: 9055794</identifier><identifier>CODEN: BRAIAK</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Cognition ; Disability Evaluation ; Female ; Frontal Lobe - pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Mental Processes ; Multiple Sclerosis - pathology ; Multiple Sclerosis - psychology ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Neuropsychological Tests ; Psychomotor Performance</subject><ispartof>Brain (London, England : 1878), 1997, Vol.120 (1), p.15-26</ispartof><rights>1997 INIST-CNRS</rights><rights>Copyright Oxford University Press Jan 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-e04fa19373d27a064444b87fbccb38ff0bfe62c152c565ae1bd553ec204a4a63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2567000$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9055794$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FOONG, J</creatorcontrib><creatorcontrib>ROZEWICZ, L</creatorcontrib><creatorcontrib>QUAGHEBEUR, G</creatorcontrib><creatorcontrib>DAVIE, C. 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Although a number of executive test scores correlated with the severity of frontal lesion load, it was difficult to disentangle the specific contribution of frontal lobe pathology to the impairment on executive tasks. This study highlights the difficulties in attempting to attribute specific cognitive abnormalities to focal brain pathology in the presence of widespread disease such as in multiple sclerosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cognition</subject><subject>Disability Evaluation</subject><subject>Female</subject><subject>Frontal Lobe - pathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental Processes</subject><subject>Multiple Sclerosis - pathology</subject><subject>Multiple Sclerosis - psychology</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Psychomotor Performance</subject><issn>0006-8950</issn><issn>1460-2156</issn><issn>1460-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLAzEUhYMoWh9bd0IQcTftzXNm3EnxBQU33YdMmmgkndRkRvTfG7W4cOPdhJv75VxyDkKnBKYEWjbrkvb9jNDSTonYQRPCJVSUCLmLJgAgq6YVcIAOc34BIJxRuY_2WxCibvkELW7erRkH_2axG3sz-Nhj3-P1GAa_CRZnE2yK2ecrvHy2OMVyFx12KfaDDjjEzuKNHp5jiE8fx2jP6ZDtyfY8Qsvbm-X8vlo83j3MrxeV4aQeKgvcadKymq1orUHyUl1Tu86YjjXOQeespIYIaoQU2pJuJQSzhgLXXEt2hC5_ZDcpvo42D2rts7Eh6N7GMau6aQTlrPkXpCChkYIW8PwP-BLH1Jc_KNKK4pmQpEDTH8gUQ3KyTm2SX-v0oQioryzUdxaqZKGIIqI8ONuqjt3arn7xrfllfrGd62x0cEn3xudfrCytS4DsE0yBkd0</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>FOONG, J</creator><creator>ROZEWICZ, L</creator><creator>QUAGHEBEUR, G</creator><creator>DAVIE, C. 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| ispartof | Brain (London, England : 1878), 1997, Vol.120 (1), p.15-26 |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Biological and medical sciences Cognition Disability Evaluation Female Frontal Lobe - pathology Humans Magnetic Resonance Imaging Male Medical sciences Mental Processes Multiple Sclerosis - pathology Multiple Sclerosis - psychology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Neuropsychological Tests Psychomotor Performance |
| title | Executive function in multiple sclerosis: The role of frontal lobe pathology |
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