Lack of site-specific integration of the recombinant adeno-associated virus 2 genomes in human cells

The adeno-associated virus 2 (AAV)-based vector system has been suggested for its potential use in human gene therapy because the wild-type (wt) AAV genome appears to integrate into the human chromosomal DNA in a site-specific manner. We systematically investigated the integration patterns of the re...

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Veröffentlicht in:	Human gene therapy 1997-02, Vol.8 (3), p.275-284
Hauptverfasser:	Ponnazhagan, S, Erikson, D, Kearns, W G, Zhou, S Z, Nahreini, P, Wang, X S, Srivastava, A
Format:	Artikel
Sprache:	eng
Schlagworte:	adeno-associated virus 2 Dependovirus - genetics Dependovirus - isolation & purification DNA Transposable Elements - genetics DNA, Recombinant - isolation & purification Genetic Vectors - genetics Genome, Viral herpesvirus Humans Recombination, Genetic - genetics Tumor Cells, Cultured Virus Integration
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