Protein tyrosine kinases in granulocyte colony stimulating factor receptor signal transduction, myeloid cell proliferation, and neutrophil activation

Granulocyte colony-stimulating factor (G-CSF) plays an important role in the growth and maturation of granulocytic precursor cells. Although the interaction between G-CSF and its receptor (G-CSF-R) is an obligatory event during proliferation and differentiation of myeloid cells, the signal transduct...

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Veröffentlicht in:	Life sciences (1973) 1997, Vol.60 (9), p.587-604
Hauptverfasser:	Deshpande, Rajendra V., Peterson, Robert H.F., Moore, Malcolm A.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cell Division Cell Line cell signalling cellular proliferation Colony-Forming Units Assay Enzyme Inhibitors - pharmacology Granulocyte Colony-Stimulating Factor - antagonists & inhibitors Granulocyte Colony-Stimulating Factor - metabolism Granulocyte Colony-Stimulating Factor - pharmacology growth factors HL-60 Cells Humans In Vitro Techniques macrophage Macrophage-1 Antigen - metabolism Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mice Monocytes - cytology Monocytes - drug effects Monocytes - metabolism neutrophils Neutrophils - cytology Neutrophils - drug effects Neutrophils - metabolism Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Receptors, Granulocyte Colony-Stimulating Factor - metabolism Signal Transduction
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