Effect of morphine on lipopolysaccharide-induced tumor necrosis factor- α production in vivo: involvement of the sympathetic nervous system

Morphine treatment modulates a variety of immunological parameters, including tumor necrosis factor- α (TNF- α) production by activated macrophages in vitro. The aim of our study was to clarify the effect of morphine on lipopolysaccharide (LPS)-induced TNF- α production in vivo. Plasma TNF- α levels...

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Veröffentlicht in:	Journal of neuroimmunology 1997-03, Vol.73 (1), p.1-6
Hauptverfasser:	Bencsics, Agnes, Elenkov, Ilia J, Vizi, E.Sylvester
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dose-Response Relationship, Drug In vivo Lipopolysaccharide Lipopolysaccharides - pharmacology Male Mice Morphine Morphine - pharmacology Naloxone - pharmacology Narcotic Antagonists - pharmacology Narcotics - pharmacology Neuroimmunomodulation Norepinephrine Opioid receptors Receptors, Opioid - physiology Sympathetic nervous system Sympathetic Nervous System - physiology Time Factors Tumor necrosis factor alpha Tumor Necrosis Factor-alpha - biosynthesis
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