Stereoselective Reductive Metabolism of Metyrapone and Inhibitory Activity of Metyrapone Metabolites, Metyrapol Enantiomers, on Steroid 11β-Hydroxylase in the Rat

Pharmacokinetics of metyrapone and metyrapol enantiomers was studied in the rat to determine the stereoselective reductive metabolism of metyrapone. The HPLC method using a chiral column was developed for the stereoselective analysis of metyrapol enantiomers in rat plasma. The AUC ratio of (-)- and...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1997/02/15, Vol.20(2), pp.188-192
Hauptverfasser:	NAGAMINE, Sachiko, HORISAKA, Eri, FUKUYAMA, Yukari, MAETANI, Kiyomi, MATSUZAWA, Ryo, IWAKAWA, Seigo, ASADA, Shozo
Format:	Artikel
Sprache:	eng
Schlagworte:	11β-hydroxylase Adrenal Glands - drug effects Adrenal Glands - enzymology Animals Biological and medical sciences Contrast media. Radiopharmaceuticals enantiometric metabolite Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacokinetics Enzyme Inhibitors - pharmacology Male Medical sciences metyrapone Metyrapone - analogs & derivatives Metyrapone - metabolism Metyrapone - pharmacokinetics Metyrapone - pharmacology pharmacokinetics Pharmacology. Drug treatments rat adrenal Rats Rats, Wistar Stereoisomerism stereoselective reduction Steroid 11-beta-Hydroxylase - antagonists & inhibitors
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