Finally! The Brambell receptor (FcRB). Mediator of transmission of immunity and protection from catabolism for IgG

F. W. Rogers Brambell was the father of the field of transmission of immunity, which he entered 50 years before the present era. As part of his quantitative and temporal studies on transmission, he defined the first Fc receptor system for IgG, and furthermore recognized the link between transmission...

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Veröffentlicht in:	Immunologic research 1997-02, Vol.16 (1), p.29-57
1. Verfasser:	Junghans, R P
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology - history Animals Biological Transport - immunology Brambell Brambell, F W Rogers Endothelium, Vascular - immunology Endothelium, Vascular - metabolism History of medicine History, 20th Century Humans Immunity, Maternally-Acquired Immunoglobulin G - history Immunoglobulin G - immunology Immunology Mice Molecular biology Physiology Rabbits Receptors, Fc - history Receptors, Fc - immunology Receptors, Fc - physiology Receptors, IgG - immunology Receptors, IgG - physiology
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Beschreibung
Zusammenfassung:	F. W. Rogers Brambell was the father of the field of transmission of immunity, which he entered 50 years before the present era. As part of his quantitative and temporal studies on transmission, he defined the first Fc receptor system for IgG, and furthermore recognized the link between transmission of passive immunity from mother to young and protection from catabolism for IgG. This article provides a historical overview of the efforts of Professor Brambell and summarizes the subsequent elaboration of the details of the physiology and molecular biology of this remarkable receptor system.
ISSN:	0257-277X 1559-0755
DOI:	10.1007/BF02786322