AL-1-induced Growth Cone Collapse of Rat Cortical Neurons is Correlated with REK7 Expression and Rearrangement of the Actin Cytoskeleton

Previous experiments identified AL‐1 as a glycosylphosphatidylinositol (GPI)‐linked ligand for the Eph‐related receptor, REK7, and showed that a REK7‐IgG fusion protein blocks axon bundling in co‐cultures of cortical neurons on astrocytes, suggesting a role for REK7 and AL‐1 in axon fasciculation. S...

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Veröffentlicht in:	The European journal of neuroscience 1997-01, Vol.9 (1), p.177-188
Hauptverfasser:	Meima, Leonie, Kljavin, Ivar J., Moran, Paul, Shih, Ai, Winslow, John W., Caras, Ingrid W.
Format:	Artikel
Sprache:	eng
Schlagworte:	actin cytoskeleton Actins - biosynthesis Animals axon guidance CD4 Antigens - metabolism Cerebral Cortex - drug effects Cerebral Cortex - growth & development Cerebral Cortex - metabolism Cytoskeleton - drug effects Cytoskeleton - metabolism Ephrin-A2 fasciculation Fluorescent Antibody Technique, Indirect Glycosylphosphatidylinositols - pharmacology Histocytochemistry Ligands Neurons - drug effects Neurons - metabolism Neurons - physiology Rats Receptor Protein-Tyrosine Kinases - biosynthesis Receptor Protein-Tyrosine Kinases - genetics Retina - cytology Rhodamines Transcription Factors - pharmacology Visual Cortex - cytology Visual Cortex - growth & development
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