Solid-phase synthesis of 16 potent (selective and nonselective) in vivo antagonists of oxytocin

We describe the synthesis and some pharmacological properties of 16 new in vivo antagonists of oxytocin. These are based on modifications of three peptides: A, B, and C. A is our previously reported potent and selective antagonist of the vasopressor (V1 receptor) responses to arginine-vasopressin (A...

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Veröffentlicht in:	Journal of medicinal chemistry 1989-02, Vol.32 (2), p.382-391
Hauptverfasser:	Manning, Maurice, Kruszynski, Marian, Bankowski, Krzysztof, Olma, Aleksandra, Lammek, Bernard, Cheng, Ling Ling, Klis, Wieslaw A, Seto, Janny, Haldar, Jaya, Sawyer, Wilbur H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine Vasopressin - analogs & derivatives Chemistry Exact sciences and technology Organic chemistry Oxytocin - antagonists & inhibitors Peptides Peptides - chemical synthesis Peptides - pharmacology Preparations and properties Rats Structure-Activity Relationship Vasotocin - analogs & derivatives
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