Effect of absorbable and nonabsorbable sugars on intestinal calcium absorption in humans
The effects of glucose, galactose, and lactitol on intestinal calcium absorption and gastric emptying were studied in 9,8, and 20 healthy subjects, respectively. Calcium absorption was measured by using a double-isotope technique and the kinetic parameters were obtained by a deconvolution method. Th...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1989-03, Vol.96 (3), p.769-775 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
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| creator | Griessen, M. Speich, P.V. Infante, F. Bartholdi, P. Cochet, B. Donath, A. Courvoisier, B. Bonjour, J-Ph |
| description | The effects of glucose, galactose, and lactitol on intestinal calcium absorption and gastric emptying were studied in 9,8, and 20 healthy subjects, respectively. Calcium absorption was measured by using a double-isotope technique and the kinetic parameters were obtained by a deconvolution method. The gastric emptying rate was determined with 99mTc-diethylenetriaminepentaacetic acid and was expressed as the half-time of the emptying curve. Each subject was studied under two conditions: (a) with calcium alone and (b) with calcium plus sugar. Glucose and galactose increased the calcium mean transit time and improved the total fractional calcium absorption by 30% (p < 0.02). Lactitol decreased the mean rate of absorption (p < 0.001) and reduced the total fractional calcium absorption by 15% (p < 0.001). The gastric emptying rate did not appear to influence directly the kinetic parameters of calcium absorption. These results show that both glucose and galactose exert the same stimulatory effect as lactose on calcium absorption in subjects with normal lactase whereas lactitol mimics the effects of lactose in lactase-deficient patients. Thus the absorbability of sugars determines their effect on calcium absorption. |
| doi_str_mv | 10.1016/0016-5085(89)90900-1 |
| format | Article |
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Calcium absorption was measured by using a double-isotope technique and the kinetic parameters were obtained by a deconvolution method. The gastric emptying rate was determined with 99mTc-diethylenetriaminepentaacetic acid and was expressed as the half-time of the emptying curve. Each subject was studied under two conditions: (a) with calcium alone and (b) with calcium plus sugar. Glucose and galactose increased the calcium mean transit time and improved the total fractional calcium absorption by 30% (p < 0.02). Lactitol decreased the mean rate of absorption (p < 0.001) and reduced the total fractional calcium absorption by 15% (p < 0.001). The gastric emptying rate did not appear to influence directly the kinetic parameters of calcium absorption. These results show that both glucose and galactose exert the same stimulatory effect as lactose on calcium absorption in subjects with normal lactase whereas lactitol mimics the effects of lactose in lactase-deficient patients. Thus the absorbability of sugars determines their effect on calcium absorption.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/0016-5085(89)90900-1</identifier><identifier>PMID: 2644153</identifier><identifier>CODEN: GASTAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; Calcium - pharmacokinetics ; Fundamental and applied biological sciences. Psychology ; Galactose - pharmacology ; Gastric Emptying - drug effects ; Glucose - pharmacology ; Humans ; Intestinal Absorption - drug effects ; Intestine. Mesentery ; Male ; Organometallic Compounds ; Pentetic Acid ; Stimulation, Chemical ; Sugar Alcohols - pharmacology ; Technetium ; Technetium Tc 99m Pentetate ; Vertebrates: digestive system</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 1989-03, Vol.96 (3), p.769-775</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-cfb0e6e83e49b0db808826b002005afed9874966c79fce73dd4ace1c49a9d0f73</citedby><cites>FETCH-LOGICAL-c388t-cfb0e6e83e49b0db808826b002005afed9874966c79fce73dd4ace1c49a9d0f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0016508589909001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6956864$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2644153$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Griessen, M.</creatorcontrib><creatorcontrib>Speich, P.V.</creatorcontrib><creatorcontrib>Infante, F.</creatorcontrib><creatorcontrib>Bartholdi, P.</creatorcontrib><creatorcontrib>Cochet, B.</creatorcontrib><creatorcontrib>Donath, A.</creatorcontrib><creatorcontrib>Courvoisier, B.</creatorcontrib><creatorcontrib>Bonjour, J-Ph</creatorcontrib><title>Effect of absorbable and nonabsorbable sugars on intestinal calcium absorption in humans</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>The effects of glucose, galactose, and lactitol on intestinal calcium absorption and gastric emptying were studied in 9,8, and 20 healthy subjects, respectively. Calcium absorption was measured by using a double-isotope technique and the kinetic parameters were obtained by a deconvolution method. The gastric emptying rate was determined with 99mTc-diethylenetriaminepentaacetic acid and was expressed as the half-time of the emptying curve. Each subject was studied under two conditions: (a) with calcium alone and (b) with calcium plus sugar. Glucose and galactose increased the calcium mean transit time and improved the total fractional calcium absorption by 30% (p < 0.02). Lactitol decreased the mean rate of absorption (p < 0.001) and reduced the total fractional calcium absorption by 15% (p < 0.001). The gastric emptying rate did not appear to influence directly the kinetic parameters of calcium absorption. These results show that both glucose and galactose exert the same stimulatory effect as lactose on calcium absorption in subjects with normal lactase whereas lactitol mimics the effects of lactose in lactase-deficient patients. Thus the absorbability of sugars determines their effect on calcium absorption.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Calcium - pharmacokinetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Galactose - pharmacology</subject><subject>Gastric Emptying - drug effects</subject><subject>Glucose - pharmacology</subject><subject>Humans</subject><subject>Intestinal Absorption - drug effects</subject><subject>Intestine. Mesentery</subject><subject>Male</subject><subject>Organometallic Compounds</subject><subject>Pentetic Acid</subject><subject>Stimulation, Chemical</subject><subject>Sugar Alcohols - pharmacology</subject><subject>Technetium</subject><subject>Technetium Tc 99m Pentetate</subject><subject>Vertebrates: digestive system</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpSDdp_0EKPpSQHJyObFmWLoUSNh-w0EsKvQlZGqUqtryR7ED_feTssuSUiwb0Pu8wPIScUbiiQPl3yE_ZgGguhLyUIAFK-oGsaFOJMmfVR7I6IJ_ISUr_AEDWgh6T44ozRpt6Rf6snUMzFaMrdJfG2Omux0IHW4QxvPlJ86OOqRhD4cOEafJB94XRvfHzsGtuJ_-aFn_nQYf0mRw53Sf8sp-n5PfN-uH6rtz8ur2__rkpTS3EVBrXAXIUNTLZge0ECFHxDqACaLRDK0XLJOemlc5gW1vLtEFqmNTSgmvrU3K-27uN49OcL1ODTwb7Xgcc56RaIVjDKppBtgNNHFOK6NQ2-kHH_4qCWoSqxZZabCkh1atQtdS-7vfP3YD2UNobzPm3fa5T9uGiDsanA8ZlwwVnGfuxwzC7ePYYVTIeg0HrY_av7Ojfv-MFYx6SfQ</recordid><startdate>19890301</startdate><enddate>19890301</enddate><creator>Griessen, M.</creator><creator>Speich, P.V.</creator><creator>Infante, F.</creator><creator>Bartholdi, P.</creator><creator>Cochet, B.</creator><creator>Donath, A.</creator><creator>Courvoisier, B.</creator><creator>Bonjour, J-Ph</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890301</creationdate><title>Effect of absorbable and nonabsorbable sugars on intestinal calcium absorption in humans</title><author>Griessen, M. ; Speich, P.V. ; Infante, F. ; Bartholdi, P. ; Cochet, B. ; Donath, A. ; Courvoisier, B. ; Bonjour, J-Ph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-cfb0e6e83e49b0db808826b002005afed9874966c79fce73dd4ace1c49a9d0f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Calcium - pharmacokinetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Galactose - pharmacology</topic><topic>Gastric Emptying - drug effects</topic><topic>Glucose - pharmacology</topic><topic>Humans</topic><topic>Intestinal Absorption - drug effects</topic><topic>Intestine. Mesentery</topic><topic>Male</topic><topic>Organometallic Compounds</topic><topic>Pentetic Acid</topic><topic>Stimulation, Chemical</topic><topic>Sugar Alcohols - pharmacology</topic><topic>Technetium</topic><topic>Technetium Tc 99m Pentetate</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Griessen, M.</creatorcontrib><creatorcontrib>Speich, P.V.</creatorcontrib><creatorcontrib>Infante, F.</creatorcontrib><creatorcontrib>Bartholdi, P.</creatorcontrib><creatorcontrib>Cochet, B.</creatorcontrib><creatorcontrib>Donath, A.</creatorcontrib><creatorcontrib>Courvoisier, B.</creatorcontrib><creatorcontrib>Bonjour, J-Ph</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Griessen, M.</au><au>Speich, P.V.</au><au>Infante, F.</au><au>Bartholdi, P.</au><au>Cochet, B.</au><au>Donath, A.</au><au>Courvoisier, B.</au><au>Bonjour, J-Ph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of absorbable and nonabsorbable sugars on intestinal calcium absorption in humans</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1989-03-01</date><risdate>1989</risdate><volume>96</volume><issue>3</issue><spage>769</spage><epage>775</epage><pages>769-775</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><coden>GASTAB</coden><abstract>The effects of glucose, galactose, and lactitol on intestinal calcium absorption and gastric emptying were studied in 9,8, and 20 healthy subjects, respectively. Calcium absorption was measured by using a double-isotope technique and the kinetic parameters were obtained by a deconvolution method. The gastric emptying rate was determined with 99mTc-diethylenetriaminepentaacetic acid and was expressed as the half-time of the emptying curve. Each subject was studied under two conditions: (a) with calcium alone and (b) with calcium plus sugar. Glucose and galactose increased the calcium mean transit time and improved the total fractional calcium absorption by 30% (p < 0.02). Lactitol decreased the mean rate of absorption (p < 0.001) and reduced the total fractional calcium absorption by 15% (p < 0.001). The gastric emptying rate did not appear to influence directly the kinetic parameters of calcium absorption. These results show that both glucose and galactose exert the same stimulatory effect as lactose on calcium absorption in subjects with normal lactase whereas lactitol mimics the effects of lactose in lactase-deficient patients. Thus the absorbability of sugars determines their effect on calcium absorption.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2644153</pmid><doi>10.1016/0016-5085(89)90900-1</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Calcium - pharmacokinetics Fundamental and applied biological sciences. Psychology Galactose - pharmacology Gastric Emptying - drug effects Glucose - pharmacology Humans Intestinal Absorption - drug effects Intestine. Mesentery Male Organometallic Compounds Pentetic Acid Stimulation, Chemical Sugar Alcohols - pharmacology Technetium Technetium Tc 99m Pentetate Vertebrates: digestive system |
| title | Effect of absorbable and nonabsorbable sugars on intestinal calcium absorption in humans |
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