Chemical modification of iron- and manganese-containing superoxide dismutases from Escherichia coli

The manganese-containing (MnSOD) and iron-containing (FeSOD) superoxide dismutases from Escherichia coli are extensively (>95%) inactivated by treatment with phenylglyoxal. The relatively high concentrations of phenylglyoxal and high pH required for optimal inactivation suggest that inactivation...

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Veröffentlicht in:	Archives of biochemistry and biophysics 1989, Vol.268 (1), p.74-80
Hauptverfasser:	Borders, C.L., Horton, Pamela J., Beyer, Wayne F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - pharmacology Analytical, structural and metabolic biochemistry Biological and medical sciences Enzymes and enzyme inhibitors Escherichia coli Escherichia coli - enzymology Fundamental and applied biological sciences. Psychology Hydrogen-Ion Concentration Isoenzymes - antagonists & inhibitors Kinetics Oxidoreductases Phenylglyoxal - pharmacology Superoxide Dismutase - antagonists & inhibitors
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