Identification of leukotriene B4 as the neutrophil chemotactic factor released by antigen challenge from passively sensitized guinea pig lungs

Neutrophils are prominent in some IgE-mediated allergic reactions and may contribute to the pathophysiology of immediate hypersensitivity. Antigen challenge of fragments of guinea pig lung tissue that were passively sensitized with IgE or IgG antibody evoked the release of neutrophil chemotactic act...

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Veröffentlicht in:	Journal of allergy and clinical immunology 1989, Vol.83 (1), p.136-143
Hauptverfasser:	ATKINS, P. C, VALENZANO, M, GOETZL, E. J, RATNOFF, W. D, GRAZIANO, F. M, ZWEIMAN, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphylaxis - immunology Anaphylaxis - physiopathology Animals Biological and medical sciences Chemotactic Factors - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Guinea Pigs Immediate hypersensitivity. Allergy. Anaphylaxis, etc Immunization, Passive Immunobiology Immunoglobulin E - physiology Immunoglobulin G - physiology Interleukin-8 Leukotriene B4 - physiology Lung - immunology Lung - metabolism Lung - physiology Male Neutrophils - immunology Neutrophils - physiology Ovalbumin - immunology Reaction mechanisms, antibodies, chemical mediators
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