Identification of leukotriene B4 as the neutrophil chemotactic factor released by antigen challenge from passively sensitized guinea pig lungs
Neutrophils are prominent in some IgE-mediated allergic reactions and may contribute to the pathophysiology of immediate hypersensitivity. Antigen challenge of fragments of guinea pig lung tissue that were passively sensitized with IgE or IgG antibody evoked the release of neutrophil chemotactic act...
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| Veröffentlicht in: | Journal of allergy and clinical immunology 1989, Vol.83 (1), p.136-143 |
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| container_title | Journal of allergy and clinical immunology |
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| creator | ATKINS, P. C VALENZANO, M GOETZL, E. J RATNOFF, W. D GRAZIANO, F. M ZWEIMAN, B |
| description | Neutrophils are prominent in some IgE-mediated allergic reactions and may contribute to the pathophysiology of immediate hypersensitivity. Antigen challenge of fragments of guinea pig lung tissue that were passively sensitized with IgE or IgG antibody evoked the release of neutrophil chemotactic activity (NCA) in parallel with histamine. The NCA released from lung tissue by both IgG- and IgE-dependent stimulation coeluted from a column of Sephacryl S-300 with synthetic leukotriene B4 (LTB4). The NCA in eluates from the Sephacryl S-300 column contained LTB4, as determined by high-performance liquid chromatography and specific radioimmunoassay, in quantities that accounted for the observed chemoattractant activity in the eluates. Furthermore, the NCA of supernatants from antigen-challenged lung fragments was reduced by a mean of 80% after absorption with a monoclonal antibody to LTB4. LTB4 thus constitutes the major functional constituent of NCA released after anaphylactic challenge of IgE- and IgG-sensitized guinea pig lung tissue. |
| doi_str_mv | 10.1016/0091-6749(89)90488-0 |
| format | Article |
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C ; VALENZANO, M ; GOETZL, E. J ; RATNOFF, W. D ; GRAZIANO, F. M ; ZWEIMAN, B</creator><creatorcontrib>ATKINS, P. C ; VALENZANO, M ; GOETZL, E. J ; RATNOFF, W. D ; GRAZIANO, F. M ; ZWEIMAN, B</creatorcontrib><description>Neutrophils are prominent in some IgE-mediated allergic reactions and may contribute to the pathophysiology of immediate hypersensitivity. Antigen challenge of fragments of guinea pig lung tissue that were passively sensitized with IgE or IgG antibody evoked the release of neutrophil chemotactic activity (NCA) in parallel with histamine. The NCA released from lung tissue by both IgG- and IgE-dependent stimulation coeluted from a column of Sephacryl S-300 with synthetic leukotriene B4 (LTB4). The NCA in eluates from the Sephacryl S-300 column contained LTB4, as determined by high-performance liquid chromatography and specific radioimmunoassay, in quantities that accounted for the observed chemoattractant activity in the eluates. Furthermore, the NCA of supernatants from antigen-challenged lung fragments was reduced by a mean of 80% after absorption with a monoclonal antibody to LTB4. LTB4 thus constitutes the major functional constituent of NCA released after anaphylactic challenge of IgE- and IgG-sensitized guinea pig lung tissue.</description><identifier>ISSN: 0091-6749</identifier><identifier>EISSN: 1097-6825</identifier><identifier>DOI: 10.1016/0091-6749(89)90488-0</identifier><identifier>PMID: 2536412</identifier><identifier>CODEN: JACIBY</identifier><language>eng</language><publisher>New York, NY: Elsevier</publisher><subject>Anaphylaxis - immunology ; Anaphylaxis - physiopathology ; Animals ; Biological and medical sciences ; Chemotactic Factors - physiology ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Guinea Pigs ; Immediate hypersensitivity. Allergy. Anaphylaxis, etc ; Immunization, Passive ; Immunobiology ; Immunoglobulin E - physiology ; Immunoglobulin G - physiology ; Interleukin-8 ; Leukotriene B4 - physiology ; Lung - immunology ; Lung - metabolism ; Lung - physiology ; Male ; Neutrophils - immunology ; Neutrophils - physiology ; Ovalbumin - immunology ; Reaction mechanisms, antibodies, chemical mediators</subject><ispartof>Journal of allergy and clinical immunology, 1989, Vol.83 (1), p.136-143</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19478090$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2536412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ATKINS, P. C</creatorcontrib><creatorcontrib>VALENZANO, M</creatorcontrib><creatorcontrib>GOETZL, E. J</creatorcontrib><creatorcontrib>RATNOFF, W. D</creatorcontrib><creatorcontrib>GRAZIANO, F. M</creatorcontrib><creatorcontrib>ZWEIMAN, B</creatorcontrib><title>Identification of leukotriene B4 as the neutrophil chemotactic factor released by antigen challenge from passively sensitized guinea pig lungs</title><title>Journal of allergy and clinical immunology</title><addtitle>J Allergy Clin Immunol</addtitle><description>Neutrophils are prominent in some IgE-mediated allergic reactions and may contribute to the pathophysiology of immediate hypersensitivity. Antigen challenge of fragments of guinea pig lung tissue that were passively sensitized with IgE or IgG antibody evoked the release of neutrophil chemotactic activity (NCA) in parallel with histamine. The NCA released from lung tissue by both IgG- and IgE-dependent stimulation coeluted from a column of Sephacryl S-300 with synthetic leukotriene B4 (LTB4). The NCA in eluates from the Sephacryl S-300 column contained LTB4, as determined by high-performance liquid chromatography and specific radioimmunoassay, in quantities that accounted for the observed chemoattractant activity in the eluates. Furthermore, the NCA of supernatants from antigen-challenged lung fragments was reduced by a mean of 80% after absorption with a monoclonal antibody to LTB4. LTB4 thus constitutes the major functional constituent of NCA released after anaphylactic challenge of IgE- and IgG-sensitized guinea pig lung tissue.</description><subject>Anaphylaxis - immunology</subject><subject>Anaphylaxis - physiopathology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chemotactic Factors - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Guinea Pigs</subject><subject>Immediate hypersensitivity. Allergy. Anaphylaxis, etc</subject><subject>Immunization, Passive</subject><subject>Immunobiology</subject><subject>Immunoglobulin E - physiology</subject><subject>Immunoglobulin G - physiology</subject><subject>Interleukin-8</subject><subject>Leukotriene B4 - physiology</subject><subject>Lung - immunology</subject><subject>Lung - metabolism</subject><subject>Lung - physiology</subject><subject>Male</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - physiology</subject><subject>Ovalbumin - immunology</subject><subject>Reaction mechanisms, antibodies, chemical mediators</subject><issn>0091-6749</issn><issn>1097-6825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90MtKJTEQBuAgI84Z9Q0UshkZF6259CVZqsyoILjR9SGdVPpE00lPkhaOD-Ez2-DBRfFT_B-1KIROKLmghLaXhEhatV0t_wh5LkktREX20IoS2VWtYM0PtPomP9GvnF_IsnMhD9ABa3hbU7ZCH_cGQnHWaVVcDDha7GF-jSU5CICva6wyLhvAAeaS4rRxHusNjLEoXZzGdomYcAIPKoPB_Rar5d4AYWHKewgDYJviiCeVs3sDv8UZQnbFvS98mF0AhSc3YD-HIR-hfat8huNdHqLnf3-fbu6qh8fb-5urh2pivC1VQwBEL1tGe9ZK0bHeKG41q00DPWNS2g6YJrRrTG8Zp4Jww5jly_TWNIYforOvu1OK_2fIZT26rMF7FSDOed0JUdeNpAs83cG5H8Gsp-RGlbbr3QOX_veuV1krb5MK2uVvRmXdCSIJ_wRe8oNu</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>ATKINS, P. C</creator><creator>VALENZANO, M</creator><creator>GOETZL, E. J</creator><creator>RATNOFF, W. D</creator><creator>GRAZIANO, F. M</creator><creator>ZWEIMAN, B</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Identification of leukotriene B4 as the neutrophil chemotactic factor released by antigen challenge from passively sensitized guinea pig lungs</title><author>ATKINS, P. C ; VALENZANO, M ; GOETZL, E. J ; RATNOFF, W. D ; GRAZIANO, F. M ; ZWEIMAN, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p236t-50ee8b9621b269872bda3fc24d5eb2299f7e2c0175dbf231803d22f322fbfd5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Anaphylaxis - immunology</topic><topic>Anaphylaxis - physiopathology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chemotactic Factors - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Guinea Pigs</topic><topic>Immediate hypersensitivity. Allergy. Anaphylaxis, etc</topic><topic>Immunization, Passive</topic><topic>Immunobiology</topic><topic>Immunoglobulin E - physiology</topic><topic>Immunoglobulin G - physiology</topic><topic>Interleukin-8</topic><topic>Leukotriene B4 - physiology</topic><topic>Lung - immunology</topic><topic>Lung - metabolism</topic><topic>Lung - physiology</topic><topic>Male</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - physiology</topic><topic>Ovalbumin - immunology</topic><topic>Reaction mechanisms, antibodies, chemical mediators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ATKINS, P. C</creatorcontrib><creatorcontrib>VALENZANO, M</creatorcontrib><creatorcontrib>GOETZL, E. J</creatorcontrib><creatorcontrib>RATNOFF, W. D</creatorcontrib><creatorcontrib>GRAZIANO, F. 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M</au><au>ZWEIMAN, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of leukotriene B4 as the neutrophil chemotactic factor released by antigen challenge from passively sensitized guinea pig lungs</atitle><jtitle>Journal of allergy and clinical immunology</jtitle><addtitle>J Allergy Clin Immunol</addtitle><date>1989</date><risdate>1989</risdate><volume>83</volume><issue>1</issue><spage>136</spage><epage>143</epage><pages>136-143</pages><issn>0091-6749</issn><eissn>1097-6825</eissn><coden>JACIBY</coden><abstract>Neutrophils are prominent in some IgE-mediated allergic reactions and may contribute to the pathophysiology of immediate hypersensitivity. Antigen challenge of fragments of guinea pig lung tissue that were passively sensitized with IgE or IgG antibody evoked the release of neutrophil chemotactic activity (NCA) in parallel with histamine. The NCA released from lung tissue by both IgG- and IgE-dependent stimulation coeluted from a column of Sephacryl S-300 with synthetic leukotriene B4 (LTB4). The NCA in eluates from the Sephacryl S-300 column contained LTB4, as determined by high-performance liquid chromatography and specific radioimmunoassay, in quantities that accounted for the observed chemoattractant activity in the eluates. Furthermore, the NCA of supernatants from antigen-challenged lung fragments was reduced by a mean of 80% after absorption with a monoclonal antibody to LTB4. LTB4 thus constitutes the major functional constituent of NCA released after anaphylactic challenge of IgE- and IgG-sensitized guinea pig lung tissue.</abstract><cop>New York, NY</cop><pub>Elsevier</pub><pmid>2536412</pmid><doi>10.1016/0091-6749(89)90488-0</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Anaphylaxis - immunology Anaphylaxis - physiopathology Animals Biological and medical sciences Chemotactic Factors - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Guinea Pigs Immediate hypersensitivity. Allergy. Anaphylaxis, etc Immunization, Passive Immunobiology Immunoglobulin E - physiology Immunoglobulin G - physiology Interleukin-8 Leukotriene B4 - physiology Lung - immunology Lung - metabolism Lung - physiology Male Neutrophils - immunology Neutrophils - physiology Ovalbumin - immunology Reaction mechanisms, antibodies, chemical mediators |
| title | Identification of leukotriene B4 as the neutrophil chemotactic factor released by antigen challenge from passively sensitized guinea pig lungs |
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