Synthesis and Dihydrofolate Reductase Inhibitory Activities of 2,4-Diamino-5-deaza and 2,4-Diamino-5,10-dideaza Lipophilic Antifolates

Two series of nonclassical antifolates (2,4-diamino-5-deaza compounds 2−5 and 5,10-dideaza compounds 6−13) were synthesized as inhibitors of dihydrofolate reductase (DHFR) from Pneumocystis carinii (pc) and Toxoplasma gondii (tg) organisms that are responsible for fatal opportunistic infections in A...

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Veröffentlicht in:	Journal of medicinal chemistry 1997-02, Vol.40 (4), p.470-478
Hauptverfasser:	Gangjee, Aleem, Devraj, Rajesh, Queener, Sherry F
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS-Related Opportunistic Infections - drug therapy AIDS/HIV Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Folic Acid Antagonists - chemical synthesis Folic Acid Antagonists - chemistry Folic Acid Antagonists - pharmacology Liver - drug effects Medical sciences Pharmacology. Drug treatments Pyrimidines - pharmacology Rats Tetrahydrofolate Dehydrogenase - metabolism Trimetrexate - pharmacology
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