Prolactin regulates uterine synthesis of prostaglandins in ovariectomized rats. Effect of estradiol 17-beta
We studied the in vitro effect of prolactin on the synthesis of prostaglandins PGE and PGF 2α in the rat uterus. Uterine tissue was obtained from ovariectomized adult rats with or without estradiol-17 beta treatment. Prolactin (4 IU/ml) enhanced PGE uterine synthesis. At higher concentrations (10–15...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 1997, Vol.56 (1), p.13-16 |
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| container_title | Prostaglandins, leukotrienes and essential fatty acids |
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| creator | Motta, A.B. Viggiano, J.M. Gimeno, M.F. |
| description | We studied the in vitro effect of prolactin on the synthesis of prostaglandins PGE and PGF
2α in the rat uterus. Uterine tissue was obtained from ovariectomized adult rats with or without estradiol-17 beta treatment. Prolactin (4 IU/ml) enhanced PGE uterine synthesis. At higher concentrations (10–15 IU/ml) prolactin enhanced PGE levels and diminished PGF
2α production by uterine tissue from ovariectomized rats. When ovariectomized rats were injected with estradiol-17 beta, we observed a pattern of PGE and PGF
2α uterine synthesis similar to that of ovariectomized rats. However, the stimulatory action of PRL on PGE synthesis was augmented in the estrogenized animals. These results led us to conclude that: 1)-PRL exerts a luteotrophic action by regulating uterine tissue PGE synthesis, 2-estradiol-17 beta potentiates this action. |
| doi_str_mv | 10.1016/S0952-3278(97)90519-6 |
| format | Article |
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2α in the rat uterus. Uterine tissue was obtained from ovariectomized adult rats with or without estradiol-17 beta treatment. Prolactin (4 IU/ml) enhanced PGE uterine synthesis. At higher concentrations (10–15 IU/ml) prolactin enhanced PGE levels and diminished PGF
2α production by uterine tissue from ovariectomized rats. When ovariectomized rats were injected with estradiol-17 beta, we observed a pattern of PGE and PGF
2α uterine synthesis similar to that of ovariectomized rats. However, the stimulatory action of PRL on PGE synthesis was augmented in the estrogenized animals. These results led us to conclude that: 1)-PRL exerts a luteotrophic action by regulating uterine tissue PGE synthesis, 2-estradiol-17 beta potentiates this action.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1016/S0952-3278(97)90519-6</identifier><identifier>PMID: 9044431</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Dinoprost - biosynthesis ; Estradiol - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; Hormone metabolism and regulation ; Mammalian female genital system ; Ovariectomy ; Prolactin - pharmacology ; Prostaglandins - biosynthesis ; Prostaglandins E - biosynthesis ; Rats ; Rats, Wistar ; Uterus - drug effects ; Uterus - metabolism ; Vertebrates: reproduction</subject><ispartof>Prostaglandins, leukotrienes and essential fatty acids, 1997, Vol.56 (1), p.13-16</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-eb9d1e2e7c81759df1558d54628a3601a16cb97c63e813146abf65359542d9f23</citedby><cites>FETCH-LOGICAL-c389t-eb9d1e2e7c81759df1558d54628a3601a16cb97c63e813146abf65359542d9f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0952-3278(97)90519-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27921,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2576990$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9044431$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Motta, A.B.</creatorcontrib><creatorcontrib>Viggiano, J.M.</creatorcontrib><creatorcontrib>Gimeno, M.F.</creatorcontrib><title>Prolactin regulates uterine synthesis of prostaglandins in ovariectomized rats. Effect of estradiol 17-beta</title><title>Prostaglandins, leukotrienes and essential fatty acids</title><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><description>We studied the in vitro effect of prolactin on the synthesis of prostaglandins PGE and PGF
2α in the rat uterus. Uterine tissue was obtained from ovariectomized adult rats with or without estradiol-17 beta treatment. Prolactin (4 IU/ml) enhanced PGE uterine synthesis. At higher concentrations (10–15 IU/ml) prolactin enhanced PGE levels and diminished PGF
2α production by uterine tissue from ovariectomized rats. When ovariectomized rats were injected with estradiol-17 beta, we observed a pattern of PGE and PGF
2α uterine synthesis similar to that of ovariectomized rats. However, the stimulatory action of PRL on PGE synthesis was augmented in the estrogenized animals. These results led us to conclude that: 1)-PRL exerts a luteotrophic action by regulating uterine tissue PGE synthesis, 2-estradiol-17 beta potentiates this action.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dinoprost - biosynthesis</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone metabolism and regulation</subject><subject>Mammalian female genital system</subject><subject>Ovariectomy</subject><subject>Prolactin - pharmacology</subject><subject>Prostaglandins - biosynthesis</subject><subject>Prostaglandins E - biosynthesis</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Uterus - drug effects</subject><subject>Uterus - metabolism</subject><subject>Vertebrates: reproduction</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LHTEUhkOx2KvtTxCyKFIXY_Mx-VpJEauC0ELbdcgkJzbt3BlNMoL99c31Xu7WVSDneZP3PAidUHJOCZWffxAjWMeZ0p-MOjNEUNPJN2hFBWcd04wfoNUeeYeOSvlDCGGU9ofo0JC-7zldob_f8zw6X9OEM9wvo6tQ8FIhpwlweZ7qbyip4DnihzyX6u5HN4U0FdwC85PLCXyd1-kfBJxdLef4KsZ2tQlAqdmFNI-Yqm6A6t6jt9GNBT7szmP06-vVz8ub7u7b9e3ll7vOc21qB4MJFBgor6kSJkQqhA6il0w7Lgl1VPrBKC85aMppL90QpeDCiJ4FExk_Rqfbd1vlx6XVsOtUPIytOsxLsUrrnjW6gWIL-rZbyRDtQ05rl58tJXYj2b5IthuD1ij7ItnKljvZfbAMawj71M5qm3_czV3xbozZTT6VPcaEksaQhl1sMWgynhJkW3yCyUNIuTm0YU6vFPkPuTKZlg</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Motta, A.B.</creator><creator>Viggiano, J.M.</creator><creator>Gimeno, M.F.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Prolactin regulates uterine synthesis of prostaglandins in ovariectomized rats. Effect of estradiol 17-beta</title><author>Motta, A.B. ; Viggiano, J.M. ; Gimeno, M.F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-eb9d1e2e7c81759df1558d54628a3601a16cb97c63e813146abf65359542d9f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dinoprost - biosynthesis</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone metabolism and regulation</topic><topic>Mammalian female genital system</topic><topic>Ovariectomy</topic><topic>Prolactin - pharmacology</topic><topic>Prostaglandins - biosynthesis</topic><topic>Prostaglandins E - biosynthesis</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Uterus - drug effects</topic><topic>Uterus - metabolism</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Motta, A.B.</creatorcontrib><creatorcontrib>Viggiano, J.M.</creatorcontrib><creatorcontrib>Gimeno, M.F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Motta, A.B.</au><au>Viggiano, J.M.</au><au>Gimeno, M.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prolactin regulates uterine synthesis of prostaglandins in ovariectomized rats. Effect of estradiol 17-beta</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>1997</date><risdate>1997</risdate><volume>56</volume><issue>1</issue><spage>13</spage><epage>16</epage><pages>13-16</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>We studied the in vitro effect of prolactin on the synthesis of prostaglandins PGE and PGF
2α in the rat uterus. Uterine tissue was obtained from ovariectomized adult rats with or without estradiol-17 beta treatment. Prolactin (4 IU/ml) enhanced PGE uterine synthesis. At higher concentrations (10–15 IU/ml) prolactin enhanced PGE levels and diminished PGF
2α production by uterine tissue from ovariectomized rats. When ovariectomized rats were injected with estradiol-17 beta, we observed a pattern of PGE and PGF
2α uterine synthesis similar to that of ovariectomized rats. However, the stimulatory action of PRL on PGE synthesis was augmented in the estrogenized animals. These results led us to conclude that: 1)-PRL exerts a luteotrophic action by regulating uterine tissue PGE synthesis, 2-estradiol-17 beta potentiates this action.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>9044431</pmid><doi>10.1016/S0952-3278(97)90519-6</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0952-3278 |
| ispartof | Prostaglandins, leukotrienes and essential fatty acids, 1997, Vol.56 (1), p.13-16 |
| issn | 0952-3278 1532-2823 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Biological and medical sciences Dinoprost - biosynthesis Estradiol - pharmacology Female Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Mammalian female genital system Ovariectomy Prolactin - pharmacology Prostaglandins - biosynthesis Prostaglandins E - biosynthesis Rats Rats, Wistar Uterus - drug effects Uterus - metabolism Vertebrates: reproduction |
| title | Prolactin regulates uterine synthesis of prostaglandins in ovariectomized rats. Effect of estradiol 17-beta |
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