Preparation and Evaluation of Solid Dispersions of Pilocarpine Hydrochloride for Alleviation of Xerostomia
This investigation was carried out to try the application of pilocarpine hydrochloride (PC) solid dispersion as sustained release dosage form. Four preparations of PC with ethylcellulose and/or hydroxypropylmethylcellulose phthalate were prepared by the organic solvent method. The preparation D incl...
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| Veröffentlicht in: | YAKUGAKU ZASSHI 1997/01/25, Vol.117(1), pp.59-64 |
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| container_title | YAKUGAKU ZASSHI |
| container_volume | 117 |
| creator | ODA, Masako SATO, Michiko YAGI, Naomi OHNO, Kosei MIYAZAKI, Shozo WATANABE, Shigeru TAKADA, Masahiko |
| description | This investigation was carried out to try the application of pilocarpine hydrochloride (PC) solid dispersion as sustained release dosage form. Four preparations of PC with ethylcellulose and/or hydroxypropylmethylcellulose phthalate were prepared by the organic solvent method. The preparation D including PC : ethylcellulose : hydroxypropylmethylcellulose phthalate (1 : 9 : 10 at weight ratio) showed the best sustained release behavior in dissolution test among four preparations. The preparation D was examined by powder X-ray diffractometry and differential scanning calorimetry, and confirmed to be solid dispersion. Saliva secretory effect of preparation D was examined in healthy male volunteers, and its effect for Xerostomia was showed. |
| doi_str_mv | 10.1248/yakushi1947.117.1_59 |
| format | Article |
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Four preparations of PC with ethylcellulose and/or hydroxypropylmethylcellulose phthalate were prepared by the organic solvent method. The preparation D including PC : ethylcellulose : hydroxypropylmethylcellulose phthalate (1 : 9 : 10 at weight ratio) showed the best sustained release behavior in dissolution test among four preparations. The preparation D was examined by powder X-ray diffractometry and differential scanning calorimetry, and confirmed to be solid dispersion. Saliva secretory effect of preparation D was examined in healthy male volunteers, and its effect for Xerostomia was showed.</description><identifier>ISSN: 0031-6903</identifier><identifier>EISSN: 1347-5231</identifier><identifier>DOI: 10.1248/yakushi1947.117.1_59</identifier><identifier>PMID: 9120802</identifier><language>eng ; jpn</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Cellulose - analogs & derivatives ; Delayed-Action Preparations ; dissolution profile ; Dosage Forms ; Humans ; Hypromellose Derivatives ; Male ; Methylcellulose - analogs & derivatives ; Pilocarpine - pharmacology ; pilocarpine hydrochloride ; Saliva - metabolism ; saliva secretion ; solid dispersion ; Stimulation, Chemical ; xerostomia ; Xerostomia - drug therapy</subject><ispartof>YAKUGAKU ZASSHI, 1997/01/25, Vol.117(1), pp.59-64</ispartof><rights>by the PHARMACEUTICAL SOCIETY OF JAPAN</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9120802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ODA, Masako</creatorcontrib><creatorcontrib>SATO, Michiko</creatorcontrib><creatorcontrib>YAGI, Naomi</creatorcontrib><creatorcontrib>OHNO, Kosei</creatorcontrib><creatorcontrib>MIYAZAKI, Shozo</creatorcontrib><creatorcontrib>WATANABE, Shigeru</creatorcontrib><creatorcontrib>TAKADA, Masahiko</creatorcontrib><title>Preparation and Evaluation of Solid Dispersions of Pilocarpine Hydrochloride for Alleviation of Xerostomia</title><title>YAKUGAKU ZASSHI</title><addtitle>YAKUGAKU ZASSHI</addtitle><description>This investigation was carried out to try the application of pilocarpine hydrochloride (PC) solid dispersion as sustained release dosage form. Four preparations of PC with ethylcellulose and/or hydroxypropylmethylcellulose phthalate were prepared by the organic solvent method. The preparation D including PC : ethylcellulose : hydroxypropylmethylcellulose phthalate (1 : 9 : 10 at weight ratio) showed the best sustained release behavior in dissolution test among four preparations. The preparation D was examined by powder X-ray diffractometry and differential scanning calorimetry, and confirmed to be solid dispersion. Saliva secretory effect of preparation D was examined in healthy male volunteers, and its effect for Xerostomia was showed.</description><subject>Cellulose - analogs & derivatives</subject><subject>Delayed-Action Preparations</subject><subject>dissolution profile</subject><subject>Dosage Forms</subject><subject>Humans</subject><subject>Hypromellose Derivatives</subject><subject>Male</subject><subject>Methylcellulose - analogs & derivatives</subject><subject>Pilocarpine - pharmacology</subject><subject>pilocarpine hydrochloride</subject><subject>Saliva - metabolism</subject><subject>saliva secretion</subject><subject>solid dispersion</subject><subject>Stimulation, Chemical</subject><subject>xerostomia</subject><subject>Xerostomia - drug therapy</subject><issn>0031-6903</issn><issn>1347-5231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkFtLAzEQhYMotWj_gcI--baa294exVsFQUEF38JkNmuj6WZNdoX-e7e0Fh8cCMPMOfMRDiEnjJ4zLsuLFXwOcWFZJYtzxsansmqPTJmQRZpxwfbJlFLB0ryi4pDMYrSaUj5WxsoJmVSM05LyKfl4CqaDAL31bQJtndx8gxs2o2-SZ-9snVzb2JkQx11cL5-s8wihs61J5qs6eFw4H2xtksaH5NI58213hDcTfOz90sIxOWjARTPb9iPyenvzcjVPHx7v7q8uH1IUOe_TGopcNpkGRMwwA14iz42WNRaaaQTZAM-ELlmNFci8AI6SYqkrXlABUosjcrbhdsF_DSb2amkjGuegNX6IqihLybgQo1FujDh-MQbTqC7YJYSVYlStU1Z_UlZjymqd8nh2uuUPemnq3dE201Gfb_SP2MO72ekQeovO_AP9Re8suICgTCt-AHpbl2g</recordid><startdate>19970101</startdate><enddate>19970101</enddate><creator>ODA, Masako</creator><creator>SATO, Michiko</creator><creator>YAGI, Naomi</creator><creator>OHNO, Kosei</creator><creator>MIYAZAKI, Shozo</creator><creator>WATANABE, Shigeru</creator><creator>TAKADA, Masahiko</creator><general>The Pharmaceutical Society of Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970101</creationdate><title>Preparation and Evaluation of Solid Dispersions of Pilocarpine Hydrochloride for Alleviation of Xerostomia</title><author>ODA, Masako ; SATO, Michiko ; YAGI, Naomi ; OHNO, Kosei ; MIYAZAKI, Shozo ; WATANABE, Shigeru ; TAKADA, Masahiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-da764f5baccc5c5a28c26eb4dc7b1bca4fa253b81dc9a467a2c40c8b92703a4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>1997</creationdate><topic>Cellulose - analogs & derivatives</topic><topic>Delayed-Action Preparations</topic><topic>dissolution profile</topic><topic>Dosage Forms</topic><topic>Humans</topic><topic>Hypromellose Derivatives</topic><topic>Male</topic><topic>Methylcellulose - analogs & derivatives</topic><topic>Pilocarpine - pharmacology</topic><topic>pilocarpine hydrochloride</topic><topic>Saliva - metabolism</topic><topic>saliva secretion</topic><topic>solid dispersion</topic><topic>Stimulation, Chemical</topic><topic>xerostomia</topic><topic>Xerostomia - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ODA, Masako</creatorcontrib><creatorcontrib>SATO, Michiko</creatorcontrib><creatorcontrib>YAGI, Naomi</creatorcontrib><creatorcontrib>OHNO, Kosei</creatorcontrib><creatorcontrib>MIYAZAKI, Shozo</creatorcontrib><creatorcontrib>WATANABE, Shigeru</creatorcontrib><creatorcontrib>TAKADA, Masahiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>YAKUGAKU ZASSHI</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ODA, Masako</au><au>SATO, Michiko</au><au>YAGI, Naomi</au><au>OHNO, Kosei</au><au>MIYAZAKI, Shozo</au><au>WATANABE, Shigeru</au><au>TAKADA, Masahiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation and Evaluation of Solid Dispersions of Pilocarpine Hydrochloride for Alleviation of Xerostomia</atitle><jtitle>YAKUGAKU ZASSHI</jtitle><addtitle>YAKUGAKU ZASSHI</addtitle><date>1997-01-01</date><risdate>1997</risdate><volume>117</volume><issue>1</issue><spage>59</spage><epage>64</epage><pages>59-64</pages><issn>0031-6903</issn><eissn>1347-5231</eissn><abstract>This investigation was carried out to try the application of pilocarpine hydrochloride (PC) solid dispersion as sustained release dosage form. Four preparations of PC with ethylcellulose and/or hydroxypropylmethylcellulose phthalate were prepared by the organic solvent method. The preparation D including PC : ethylcellulose : hydroxypropylmethylcellulose phthalate (1 : 9 : 10 at weight ratio) showed the best sustained release behavior in dissolution test among four preparations. The preparation D was examined by powder X-ray diffractometry and differential scanning calorimetry, and confirmed to be solid dispersion. Saliva secretory effect of preparation D was examined in healthy male volunteers, and its effect for Xerostomia was showed.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>9120802</pmid><doi>10.1248/yakushi1947.117.1_59</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-6903 |
| ispartof | YAKUGAKU ZASSHI, 1997/01/25, Vol.117(1), pp.59-64 |
| issn | 0031-6903 1347-5231 |
| language | eng ; jpn |
| recordid | cdi_proquest_miscellaneous_78841233 |
| source | J-STAGE Free; MEDLINE; Alma/SFX Local Collection |
| subjects | Cellulose - analogs & derivatives Delayed-Action Preparations dissolution profile Dosage Forms Humans Hypromellose Derivatives Male Methylcellulose - analogs & derivatives Pilocarpine - pharmacology pilocarpine hydrochloride Saliva - metabolism saliva secretion solid dispersion Stimulation, Chemical xerostomia Xerostomia - drug therapy |
| title | Preparation and Evaluation of Solid Dispersions of Pilocarpine Hydrochloride for Alleviation of Xerostomia |
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