Myocardial Contractile Reserve as Prognostic Determinant in Patients With Idiopathic Dilated Cardiomyopathy Without Overt Heart Failure
To assess the prognostic significance of myocardial contractile reserve in patients with idiopathic dilated cardiomyopathy (DCM) without overt heart failure (New York Heart Association functional class I or II), seventy-one patients underwent exercise radionuclide angiography in addition to clinical...
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| Veröffentlicht in: | Chest 1997-02, Vol.111 (2), p.344-350 |
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| creator | Nagaoka, Hideki Isobe, Naoki Kubota, Sachio lizuka, Toshio Imai, Susumu Suzuki, Tadashi Nagai, Ryozo |
| description | To assess the prognostic significance of myocardial contractile reserve in patients with idiopathic dilated cardiomyopathy (DCM) without overt heart failure (New York Heart Association functional class I or II), seventy-one patients underwent exercise radionuclide angiography in addition to clinical, radiographic, hemodynamic, and echocardiographic evaluations. Myocardial contractile reserve was assessed as left ventricular ejection fraction (LVEF) during peak exercise minus LVEF at rest (ΔLVEF). During an average of 49 months, 18 patients died of the disease. Cox's proportional-hazards regression analysis showed that the ΔLVEF was the most powerful and independent discriminator for survival (p=0.0002). Ejection time (p=0.0029) and cardiothoracic ratio (p=0.017) were the second and third most predictive variables, respectively. Evaluation of the ΔLVEF, which reflects residual myocardial contractile reserve, can provide important information about the prognosis of patients with DCM and mild symptoms. |
| doi_str_mv | 10.1378/chest.111.2.344 |
| format | Article |
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Myocardial contractile reserve was assessed as left ventricular ejection fraction (LVEF) during peak exercise minus LVEF at rest (ΔLVEF). During an average of 49 months, 18 patients died of the disease. Cox's proportional-hazards regression analysis showed that the ΔLVEF was the most powerful and independent discriminator for survival (p=0.0002). Ejection time (p=0.0029) and cardiothoracic ratio (p=0.017) were the second and third most predictive variables, respectively. Evaluation of the ΔLVEF, which reflects residual myocardial contractile reserve, can provide important information about the prognosis of patients with DCM and mild symptoms.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.111.2.344</identifier><identifier>PMID: 9041980</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Cardiac catheterization ; Cardiology. Vascular system ; Cardiomyopathy ; Cardiomyopathy, Dilated - mortality ; Cardiomyopathy, Dilated - physiopathology ; Cardiovascular disease ; Ejection fraction ; Exercise Test ; Female ; Heart ; Heart failure ; Heart rate ; Hemodynamics ; Humans ; idiopathic dilated cardiomyopathy ; Intubation ; Male ; Medical imaging ; Medical prognosis ; Medical sciences ; Middle Aged ; myocardial contractile reserve ; Myocardial Contraction ; Myocarditis. Cardiomyopathies ; Patients ; Prognosis ; Proportional Hazards Models ; Radionuclide Angiography ; Stroke Volume ; Survival Rate ; Ventricular Function, Left</subject><ispartof>Chest, 1997-02, Vol.111 (2), p.344-350</ispartof><rights>1997 The American College of Chest Physicians</rights><rights>1997 INIST-CNRS</rights><rights>Copyright American College of Chest Physicians Feb 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-4be133f9ec56ba7c56f7bc1da9cbc4d075dd5ab3c8bb8646812fbf1d5e1343a13</citedby><cites>FETCH-LOGICAL-c438t-4be133f9ec56ba7c56f7bc1da9cbc4d075dd5ab3c8bb8646812fbf1d5e1343a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2589086$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9041980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagaoka, Hideki</creatorcontrib><creatorcontrib>Isobe, Naoki</creatorcontrib><creatorcontrib>Kubota, Sachio</creatorcontrib><creatorcontrib>lizuka, Toshio</creatorcontrib><creatorcontrib>Imai, Susumu</creatorcontrib><creatorcontrib>Suzuki, Tadashi</creatorcontrib><creatorcontrib>Nagai, Ryozo</creatorcontrib><title>Myocardial Contractile Reserve as Prognostic Determinant in Patients With Idiopathic Dilated Cardiomyopathy Without Overt Heart Failure</title><title>Chest</title><addtitle>Chest</addtitle><description>To assess the prognostic significance of myocardial contractile reserve in patients with idiopathic dilated cardiomyopathy (DCM) without overt heart failure (New York Heart Association functional class I or II), seventy-one patients underwent exercise radionuclide angiography in addition to clinical, radiographic, hemodynamic, and echocardiographic evaluations. Myocardial contractile reserve was assessed as left ventricular ejection fraction (LVEF) during peak exercise minus LVEF at rest (ΔLVEF). During an average of 49 months, 18 patients died of the disease. Cox's proportional-hazards regression analysis showed that the ΔLVEF was the most powerful and independent discriminator for survival (p=0.0002). Ejection time (p=0.0029) and cardiothoracic ratio (p=0.017) were the second and third most predictive variables, respectively. Evaluation of the ΔLVEF, which reflects residual myocardial contractile reserve, can provide important information about the prognosis of patients with DCM and mild symptoms.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiac catheterization</subject><subject>Cardiology. Vascular system</subject><subject>Cardiomyopathy</subject><subject>Cardiomyopathy, Dilated - mortality</subject><subject>Cardiomyopathy, Dilated - physiopathology</subject><subject>Cardiovascular disease</subject><subject>Ejection fraction</subject><subject>Exercise Test</subject><subject>Female</subject><subject>Heart</subject><subject>Heart failure</subject><subject>Heart rate</subject><subject>Hemodynamics</subject><subject>Humans</subject><subject>idiopathic dilated cardiomyopathy</subject><subject>Intubation</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>myocardial contractile reserve</subject><subject>Myocardial Contraction</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Radionuclide Angiography</subject><subject>Stroke Volume</subject><subject>Survival Rate</subject><subject>Ventricular Function, Left</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kUFv1DAQhSMEKtvCmROShVBv2dqxk3WOaEtppaJWCMTRmtiTxlUSL7azaH8BfxvvblQQEhdb9nzvzWhelr1hdMn4Sl7oDkNcMsaWxZIL8SxbsJqznJeCP88WlLIi51VdvMxOQ3ik6c3q6iQ7qalgtaSL7NfnndPgjYWerN0YPehoeyRfMKDfIoFA7r17GF2IVpNLjOgHO8IYiR3JPUSLYwzku40duTHWbSB2e872ENGQ9d7ZDbvD_-6AuSmSuy36SK4R0nkFtp88vspetNAHfD3fZ9m3q49f19f57d2nm_WH21wLLmMuGmSctzXqsmpglc521WhmoNaNFoauSmNKaLiWTSMrUUlWtE3LTJlkggPjZ9n50Xfj3Y8p7U4NNmjsexjRTUGtpBRpRzyB7_4BH93kxzSbKigVtKBCJujiCGnvQvDYqo23A_idYlTt81GHfFTKRxUq5ZMUb2fbqRnQPPFzIKn-fq5D0NC3HkZtwxNWlLKmsvrTuLMP3U_rUYUB-j6Z8mPLedi_G9dHBabtbi16FXQKT6NJah2Vcfa_Q_8GoILAsQ</recordid><startdate>19970201</startdate><enddate>19970201</enddate><creator>Nagaoka, Hideki</creator><creator>Isobe, Naoki</creator><creator>Kubota, Sachio</creator><creator>lizuka, Toshio</creator><creator>Imai, Susumu</creator><creator>Suzuki, Tadashi</creator><creator>Nagai, Ryozo</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>19970201</creationdate><title>Myocardial Contractile Reserve as Prognostic Determinant in Patients With Idiopathic Dilated Cardiomyopathy Without Overt Heart Failure</title><author>Nagaoka, Hideki ; Isobe, Naoki ; Kubota, Sachio ; lizuka, Toshio ; Imai, Susumu ; Suzuki, Tadashi ; Nagai, Ryozo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-4be133f9ec56ba7c56f7bc1da9cbc4d075dd5ab3c8bb8646812fbf1d5e1343a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiac catheterization</topic><topic>Cardiology. Vascular system</topic><topic>Cardiomyopathy</topic><topic>Cardiomyopathy, Dilated - mortality</topic><topic>Cardiomyopathy, Dilated - physiopathology</topic><topic>Cardiovascular disease</topic><topic>Ejection fraction</topic><topic>Exercise Test</topic><topic>Female</topic><topic>Heart</topic><topic>Heart failure</topic><topic>Heart rate</topic><topic>Hemodynamics</topic><topic>Humans</topic><topic>idiopathic dilated cardiomyopathy</topic><topic>Intubation</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>myocardial contractile reserve</topic><topic>Myocardial Contraction</topic><topic>Myocarditis. Cardiomyopathies</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Radionuclide Angiography</topic><topic>Stroke Volume</topic><topic>Survival Rate</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagaoka, Hideki</creatorcontrib><creatorcontrib>Isobe, Naoki</creatorcontrib><creatorcontrib>Kubota, Sachio</creatorcontrib><creatorcontrib>lizuka, Toshio</creatorcontrib><creatorcontrib>Imai, Susumu</creatorcontrib><creatorcontrib>Suzuki, Tadashi</creatorcontrib><creatorcontrib>Nagai, Ryozo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagaoka, Hideki</au><au>Isobe, Naoki</au><au>Kubota, Sachio</au><au>lizuka, Toshio</au><au>Imai, Susumu</au><au>Suzuki, Tadashi</au><au>Nagai, Ryozo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial Contractile Reserve as Prognostic Determinant in Patients With Idiopathic Dilated Cardiomyopathy Without Overt Heart Failure</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1997-02-01</date><risdate>1997</risdate><volume>111</volume><issue>2</issue><spage>344</spage><epage>350</epage><pages>344-350</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>To assess the prognostic significance of myocardial contractile reserve in patients with idiopathic dilated cardiomyopathy (DCM) without overt heart failure (New York Heart Association functional class I or II), seventy-one patients underwent exercise radionuclide angiography in addition to clinical, radiographic, hemodynamic, and echocardiographic evaluations. Myocardial contractile reserve was assessed as left ventricular ejection fraction (LVEF) during peak exercise minus LVEF at rest (ΔLVEF). During an average of 49 months, 18 patients died of the disease. Cox's proportional-hazards regression analysis showed that the ΔLVEF was the most powerful and independent discriminator for survival (p=0.0002). Ejection time (p=0.0029) and cardiothoracic ratio (p=0.017) were the second and third most predictive variables, respectively. Evaluation of the ΔLVEF, which reflects residual myocardial contractile reserve, can provide important information about the prognosis of patients with DCM and mild symptoms.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>9041980</pmid><doi>10.1378/chest.111.2.344</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Cardiac catheterization Cardiology. Vascular system Cardiomyopathy Cardiomyopathy, Dilated - mortality Cardiomyopathy, Dilated - physiopathology Cardiovascular disease Ejection fraction Exercise Test Female Heart Heart failure Heart rate Hemodynamics Humans idiopathic dilated cardiomyopathy Intubation Male Medical imaging Medical prognosis Medical sciences Middle Aged myocardial contractile reserve Myocardial Contraction Myocarditis. Cardiomyopathies Patients Prognosis Proportional Hazards Models Radionuclide Angiography Stroke Volume Survival Rate Ventricular Function, Left |
| title | Myocardial Contractile Reserve as Prognostic Determinant in Patients With Idiopathic Dilated Cardiomyopathy Without Overt Heart Failure |
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