Functional consequences of monocyte IL-2 receptor expression. Induction of IL-1 beta secretion by IFN gamma and IL-2
The generation of an immune response involves the interaction of monocytes and T cells, but the events which regulate this interaction are not well understood. Culture of human peripheral blood monocytes in vitro induces low level surface expression of the p55 protein of the IL-2R and the expression...
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| Veröffentlicht in: | The Journal of immunology (1950) 1989-01, Vol.142 (1), p.139-143 |
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| container_title | The Journal of immunology (1950) |
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| creator | Herrmann, F Cannistra, SA Lindemann, A Blohm, D Rambaldi, A Mertelsmann, RH Griffin, JD |
| description | The generation of an immune response involves the interaction of monocytes and T cells, but the events which regulate this interaction are not well understood. Culture of human peripheral blood monocytes in vitro induces low level surface expression of the p55 protein of the IL-2R and the expression of this receptor can be enhanced significantly by exposure to IFN-gamma. The addition of IL-2 to IFN-gamma-treated monocytes was shown to augment subsequent IL-1 beta secretion in the presence or absence of LPS. These effects could be partially blocked by anti-p55-IL-2R mAb. Nuclear "run on" assays and Northern analysis to probe for IL-1 beta transcripts showed enhanced IL-1 beta gene transcription and mRNA accumulation by monocytes treated with IFN-gamma and IL-2 but not in cultures that were obtained from monocytes treated with IL-2 alone. These results suggest that the T cell lymphokines IFN-gamma and IL-2 may act in a sequential fashion on monocytes to amplify the immune response by establishing a positive feedback circuit. |
| doi_str_mv | 10.4049/jimmunol.142.1.139 |
| format | Article |
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Nuclear "run on" assays and Northern analysis to probe for IL-1 beta transcripts showed enhanced IL-1 beta gene transcription and mRNA accumulation by monocytes treated with IFN-gamma and IL-2 but not in cultures that were obtained from monocytes treated with IL-2 alone. These results suggest that the T cell lymphokines IFN-gamma and IL-2 may act in a sequential fashion on monocytes to amplify the immune response by establishing a positive feedback circuit.</description><identifier>ISSN: 0022-1767</identifier><identifier>EISSN: 1550-6606</identifier><identifier>DOI: 10.4049/jimmunol.142.1.139</identifier><identifier>PMID: 2491871</identifier><identifier>CODEN: JOIMA3</identifier><language>eng</language><publisher>Bethesda, MD: Am Assoc Immnol</publisher><subject>Adjuvants, Immunologic - pharmacology ; Analysis of the immune response. 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Psychology ; Fundamental immunology ; Humans ; Immunobiology ; Interferon-gamma - pharmacology ; Interleukin-1 - biosynthesis ; Interleukin-1 - genetics ; Interleukin-1 - metabolism ; Interleukin-2 - pharmacology ; Lipopolysaccharides ; Lymphokines, interleukins ( function, expression) ; Monocytes - drug effects ; Monocytes - metabolism ; Receptors, Interleukin-2 - drug effects ; Receptors, Interleukin-2 - immunology ; Regulatory factors and their cellular receptors ; RNA, Messenger - biosynthesis ; Transcription, Genetic - drug effects</subject><ispartof>The Journal of immunology (1950), 1989-01, Vol.142 (1), p.139-143</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-417ce1db39e58a8c3181c6e9cd46f0a42af86257e3da489ec3610a909d4a1af13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19388744$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2491871$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herrmann, F</creatorcontrib><creatorcontrib>Cannistra, SA</creatorcontrib><creatorcontrib>Lindemann, A</creatorcontrib><creatorcontrib>Blohm, D</creatorcontrib><creatorcontrib>Rambaldi, A</creatorcontrib><creatorcontrib>Mertelsmann, RH</creatorcontrib><creatorcontrib>Griffin, JD</creatorcontrib><title>Functional consequences of monocyte IL-2 receptor expression. Induction of IL-1 beta secretion by IFN gamma and IL-2</title><title>The Journal of immunology (1950)</title><addtitle>J Immunol</addtitle><description>The generation of an immune response involves the interaction of monocytes and T cells, but the events which regulate this interaction are not well understood. Culture of human peripheral blood monocytes in vitro induces low level surface expression of the p55 protein of the IL-2R and the expression of this receptor can be enhanced significantly by exposure to IFN-gamma. The addition of IL-2 to IFN-gamma-treated monocytes was shown to augment subsequent IL-1 beta secretion in the presence or absence of LPS. These effects could be partially blocked by anti-p55-IL-2R mAb. Nuclear "run on" assays and Northern analysis to probe for IL-1 beta transcripts showed enhanced IL-1 beta gene transcription and mRNA accumulation by monocytes treated with IFN-gamma and IL-2 but not in cultures that were obtained from monocytes treated with IL-2 alone. These results suggest that the T cell lymphokines IFN-gamma and IL-2 may act in a sequential fashion on monocytes to amplify the immune response by establishing a positive feedback circuit.</description><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Cell Separation</subject><subject>Cells, Cultured</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Interferon-gamma - pharmacology</subject><subject>Interleukin-1 - biosynthesis</subject><subject>Interleukin-1 - genetics</subject><subject>Interleukin-1 - metabolism</subject><subject>Interleukin-2 - pharmacology</subject><subject>Lipopolysaccharides</subject><subject>Lymphokines, interleukins ( function, expression)</subject><subject>Monocytes - drug effects</subject><subject>Monocytes - metabolism</subject><subject>Receptors, Interleukin-2 - drug effects</subject><subject>Receptors, Interleukin-2 - immunology</subject><subject>Regulatory factors and their cellular receptors</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Transcription, Genetic - drug effects</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcGO0zAQhi0EWsrCCyAh-QK3BI_jJPYRrShUquACZ2vqTHaziu1iJyp9e9JuoUdOljz__3msj7G3IEollPn4OHg_hziWoGQJJVTmGVtBXYuiaUTznK2EkLKAtmlfslc5PwohGiHVDbuRyoBuYcWm9RzcNMSAI3cxZPo1U3CUeey5jyG640R8sy0kT-RoP8XE6fc-Uc5Lp-Sb0M3n-im_xIDvaEKeySU6X--OfLP-xu_Re-QYujPrNXvR45jpzeW8ZT_Xn3_cfS22379s7j5tC6cqNRUKWkfQ7SpDtUbtKtDgGjKuU00vUEnsdSPrlqoOlTbkqgYEGmE6hYA9VLfswxN3n-LyrzxZP2RH44iB4pxtq3VlhG7_G4RaGCnViSifgi7FnBP1dp8Gj-loQdiTE_vXiV2cWLCLk6X07kKfd566f5WLhGX-_jLH7HDsEwY35CvZVFq3Sl23fBjuHw5DIps9juNCBXs4HK4P_gEaJ6N8</recordid><startdate>19890101</startdate><enddate>19890101</enddate><creator>Herrmann, F</creator><creator>Cannistra, SA</creator><creator>Lindemann, A</creator><creator>Blohm, D</creator><creator>Rambaldi, A</creator><creator>Mertelsmann, RH</creator><creator>Griffin, JD</creator><general>Am Assoc Immnol</general><general>American Association of Immunologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19890101</creationdate><title>Functional consequences of monocyte IL-2 receptor expression. Induction of IL-1 beta secretion by IFN gamma and IL-2</title><author>Herrmann, F ; Cannistra, SA ; Lindemann, A ; Blohm, D ; Rambaldi, A ; Mertelsmann, RH ; Griffin, JD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-417ce1db39e58a8c3181c6e9cd46f0a42af86257e3da489ec3610a909d4a1af13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adjuvants, Immunologic - pharmacology</topic><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Antibodies, Monoclonal</topic><topic>Biological and medical sciences</topic><topic>Cell Separation</topic><topic>Cells, Cultured</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Interferon-gamma - pharmacology</topic><topic>Interleukin-1 - biosynthesis</topic><topic>Interleukin-1 - genetics</topic><topic>Interleukin-1 - metabolism</topic><topic>Interleukin-2 - pharmacology</topic><topic>Lipopolysaccharides</topic><topic>Lymphokines, interleukins ( function, expression)</topic><topic>Monocytes - drug effects</topic><topic>Monocytes - metabolism</topic><topic>Receptors, Interleukin-2 - drug effects</topic><topic>Receptors, Interleukin-2 - immunology</topic><topic>Regulatory factors and their cellular receptors</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Transcription, Genetic - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herrmann, F</creatorcontrib><creatorcontrib>Cannistra, SA</creatorcontrib><creatorcontrib>Lindemann, A</creatorcontrib><creatorcontrib>Blohm, D</creatorcontrib><creatorcontrib>Rambaldi, A</creatorcontrib><creatorcontrib>Mertelsmann, RH</creatorcontrib><creatorcontrib>Griffin, JD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herrmann, F</au><au>Cannistra, SA</au><au>Lindemann, A</au><au>Blohm, D</au><au>Rambaldi, A</au><au>Mertelsmann, RH</au><au>Griffin, JD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functional consequences of monocyte IL-2 receptor expression. Induction of IL-1 beta secretion by IFN gamma and IL-2</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>1989-01-01</date><risdate>1989</risdate><volume>142</volume><issue>1</issue><spage>139</spage><epage>143</epage><pages>139-143</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><coden>JOIMA3</coden><abstract>The generation of an immune response involves the interaction of monocytes and T cells, but the events which regulate this interaction are not well understood. Culture of human peripheral blood monocytes in vitro induces low level surface expression of the p55 protein of the IL-2R and the expression of this receptor can be enhanced significantly by exposure to IFN-gamma. The addition of IL-2 to IFN-gamma-treated monocytes was shown to augment subsequent IL-1 beta secretion in the presence or absence of LPS. These effects could be partially blocked by anti-p55-IL-2R mAb. Nuclear "run on" assays and Northern analysis to probe for IL-1 beta transcripts showed enhanced IL-1 beta gene transcription and mRNA accumulation by monocytes treated with IFN-gamma and IL-2 but not in cultures that were obtained from monocytes treated with IL-2 alone. These results suggest that the T cell lymphokines IFN-gamma and IL-2 may act in a sequential fashion on monocytes to amplify the immune response by establishing a positive feedback circuit.</abstract><cop>Bethesda, MD</cop><pub>Am Assoc Immnol</pub><pmid>2491871</pmid><doi>10.4049/jimmunol.142.1.139</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adjuvants, Immunologic - pharmacology Analysis of the immune response. Humoral and cellular immunity Antibodies, Monoclonal Biological and medical sciences Cell Separation Cells, Cultured Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Interferon-gamma - pharmacology Interleukin-1 - biosynthesis Interleukin-1 - genetics Interleukin-1 - metabolism Interleukin-2 - pharmacology Lipopolysaccharides Lymphokines, interleukins ( function, expression) Monocytes - drug effects Monocytes - metabolism Receptors, Interleukin-2 - drug effects Receptors, Interleukin-2 - immunology Regulatory factors and their cellular receptors RNA, Messenger - biosynthesis Transcription, Genetic - drug effects |
| title | Functional consequences of monocyte IL-2 receptor expression. Induction of IL-1 beta secretion by IFN gamma and IL-2 |
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