Prednisone Pretreatment Leads to Histaminic Airway Hyporeactivity Soon after Resolution of the Immediate Allergic Response
We assessed the effect of prednisone pretreatment (50 mg/day for three days) on the development of the early increase in histamine reactivity that occurs soon after resolution of the immediate response in allergic humans. Four allergic subjects who were known to develop only isolated immediate respo...
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| Veröffentlicht in: | Chest 1989-02, Vol.95 (2), p.314-319 |
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| creator | Steinberg, Dan R. Bernstein, David I. Bernstein, I. Leonard Murlas, Christopher G. |
| description | We assessed the effect of prednisone pretreatment (50 mg/day for three days) on the development of the early increase in histamine reactivity that occurs soon after resolution of the immediate response in allergic humans. Four allergic subjects who were known to develop only isolated immediate responses upon Kentucky bluegrass inhalation, as well as four mild allergic asthmatic subjects known to develop typical dual phase responses, were evaluated. All testing was done more than nine weeks after the grass pollen season had ended. Allergen inhalation produced an immediate response in all subjects. However, upon resolution of the immediate response to allergen in these pretreated subjects, the PC200 His in all dual responding asthmatics and in three of the four isolated immediate responders had substantially increased above baseline values. We conclude that prednisone pretreatment leads to histaminic hyporeactivity soon after resolution of the immediate allergic response in both dual responding asthmatics and isolated immediate responders. It would seem that this prednisone effect is independent of its potential influence on the influx of inflammatory cells into diseased airways.
(Chest 1989; 95:314-19)
PC200His = dose of histamine that doubled SRaw; EOR=early onset increase in airway reactivity. |
| doi_str_mv | 10.1378/chest.95.2.314 |
| format | Article |
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(Chest 1989; 95:314-19)
PC200His = dose of histamine that doubled SRaw; EOR=early onset increase in airway reactivity.</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.95.2.314</identifier><identifier>PMID: 2914481</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Adult ; Airway Resistance - drug effects ; Allergens - administration & dosage ; Biological and medical sciences ; Bronchi - drug effects ; Bronchi - physiopathology ; Bronchial Provocation Tests ; Female ; Forced Expiratory Volume ; Histamine - pharmacology ; Histamine and antagonists. Allergy ; Humans ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Prednisone - administration & dosage ; Rhinitis, Allergic, Seasonal - drug therapy ; Rhinitis, Allergic, Seasonal - physiopathology</subject><ispartof>Chest, 1989-02, Vol.95 (2), p.314-319</ispartof><rights>1989 The American College of Chest Physicians</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-12a13905077593ecd73053d972daf8626e7925533b149be11e37a4dcd411ec653</citedby><cites>FETCH-LOGICAL-c438t-12a13905077593ecd73053d972daf8626e7925533b149be11e37a4dcd411ec653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7310715$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2914481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steinberg, Dan R.</creatorcontrib><creatorcontrib>Bernstein, David I.</creatorcontrib><creatorcontrib>Bernstein, I. Leonard</creatorcontrib><creatorcontrib>Murlas, Christopher G.</creatorcontrib><title>Prednisone Pretreatment Leads to Histaminic Airway Hyporeactivity Soon after Resolution of the Immediate Allergic Response</title><title>Chest</title><addtitle>Chest</addtitle><description>We assessed the effect of prednisone pretreatment (50 mg/day for three days) on the development of the early increase in histamine reactivity that occurs soon after resolution of the immediate response in allergic humans. Four allergic subjects who were known to develop only isolated immediate responses upon Kentucky bluegrass inhalation, as well as four mild allergic asthmatic subjects known to develop typical dual phase responses, were evaluated. All testing was done more than nine weeks after the grass pollen season had ended. Allergen inhalation produced an immediate response in all subjects. However, upon resolution of the immediate response to allergen in these pretreated subjects, the PC200 His in all dual responding asthmatics and in three of the four isolated immediate responders had substantially increased above baseline values. We conclude that prednisone pretreatment leads to histaminic hyporeactivity soon after resolution of the immediate allergic response in both dual responding asthmatics and isolated immediate responders. It would seem that this prednisone effect is independent of its potential influence on the influx of inflammatory cells into diseased airways.
(Chest 1989; 95:314-19)
PC200His = dose of histamine that doubled SRaw; EOR=early onset increase in airway reactivity.</description><subject>Adult</subject><subject>Airway Resistance - drug effects</subject><subject>Allergens - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Bronchi - drug effects</subject><subject>Bronchi - physiopathology</subject><subject>Bronchial Provocation Tests</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Histamine - pharmacology</subject><subject>Histamine and antagonists. Allergy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Prednisone - administration & dosage</subject><subject>Rhinitis, Allergic, Seasonal - drug therapy</subject><subject>Rhinitis, Allergic, Seasonal - physiopathology</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2PFCEQxYnRrOPq1ZsJB-OtW2iapjlONupsMonGjzNhoHqHDQ0j0LsZ_3rRmaxejCcK6lfvkXoIvaSkpUyMb80ecmklb7uW0f4RWlHJaMN4zx6jFSG0a9ggu6foWc63pN6pHC7QRSdp3490hX58SmCDyzEArmVJoMsMoeAtaJtxiXjjctGzC87gtUv3-og3x0OsnCnuzpUj_hJjwHoqkPBnyNEvxdWHOOGyB3w9z2CdLoDX3kO6qSoVOsSQ4Tl6Mmmf4cX5vETf3r_7erVpth8_XF-tt43p2Vga2mnKJOFECC4ZGCsY4cxK0Vk9jUM3gJAd54ztaC93QCkwoXtrbF9LM3B2id6cdA8pfl_qttTssgHvdYC4ZCXGkY2kav8PpJxJORBRwfYEmhRzTjCpQ3KzTkdFifqVivqdipJcdaqmUgdenZWXXd3HA36OofZfn_s6G-2npINx-QETjBJB-R_fvbvZ37sEKs_a-yrKTo63cUlB-798x9MA1P3eOUgqGwfB1EgSmKJsdP_68k8LCbsk</recordid><startdate>19890201</startdate><enddate>19890201</enddate><creator>Steinberg, Dan R.</creator><creator>Bernstein, David I.</creator><creator>Bernstein, I. Leonard</creator><creator>Murlas, Christopher G.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19890201</creationdate><title>Prednisone Pretreatment Leads to Histaminic Airway Hyporeactivity Soon after Resolution of the Immediate Allergic Response</title><author>Steinberg, Dan R. ; Bernstein, David I. ; Bernstein, I. Leonard ; Murlas, Christopher G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-12a13905077593ecd73053d972daf8626e7925533b149be11e37a4dcd411ec653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Airway Resistance - drug effects</topic><topic>Allergens - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Bronchi - drug effects</topic><topic>Bronchi - physiopathology</topic><topic>Bronchial Provocation Tests</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Histamine - pharmacology</topic><topic>Histamine and antagonists. Allergy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Prednisone - administration & dosage</topic><topic>Rhinitis, Allergic, Seasonal - drug therapy</topic><topic>Rhinitis, Allergic, Seasonal - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steinberg, Dan R.</creatorcontrib><creatorcontrib>Bernstein, David I.</creatorcontrib><creatorcontrib>Bernstein, I. Leonard</creatorcontrib><creatorcontrib>Murlas, Christopher G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steinberg, Dan R.</au><au>Bernstein, David I.</au><au>Bernstein, I. Leonard</au><au>Murlas, Christopher G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prednisone Pretreatment Leads to Histaminic Airway Hyporeactivity Soon after Resolution of the Immediate Allergic Response</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1989-02-01</date><risdate>1989</risdate><volume>95</volume><issue>2</issue><spage>314</spage><epage>319</epage><pages>314-319</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>We assessed the effect of prednisone pretreatment (50 mg/day for three days) on the development of the early increase in histamine reactivity that occurs soon after resolution of the immediate response in allergic humans. Four allergic subjects who were known to develop only isolated immediate responses upon Kentucky bluegrass inhalation, as well as four mild allergic asthmatic subjects known to develop typical dual phase responses, were evaluated. All testing was done more than nine weeks after the grass pollen season had ended. Allergen inhalation produced an immediate response in all subjects. However, upon resolution of the immediate response to allergen in these pretreated subjects, the PC200 His in all dual responding asthmatics and in three of the four isolated immediate responders had substantially increased above baseline values. We conclude that prednisone pretreatment leads to histaminic hyporeactivity soon after resolution of the immediate allergic response in both dual responding asthmatics and isolated immediate responders. It would seem that this prednisone effect is independent of its potential influence on the influx of inflammatory cells into diseased airways.
(Chest 1989; 95:314-19)
PC200His = dose of histamine that doubled SRaw; EOR=early onset increase in airway reactivity.</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>2914481</pmid><doi>10.1378/chest.95.2.314</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adult Airway Resistance - drug effects Allergens - administration & dosage Biological and medical sciences Bronchi - drug effects Bronchi - physiopathology Bronchial Provocation Tests Female Forced Expiratory Volume Histamine - pharmacology Histamine and antagonists. Allergy Humans Male Medical sciences Pharmacology. Drug treatments Prednisone - administration & dosage Rhinitis, Allergic, Seasonal - drug therapy Rhinitis, Allergic, Seasonal - physiopathology |
| title | Prednisone Pretreatment Leads to Histaminic Airway Hyporeactivity Soon after Resolution of the Immediate Allergic Response |
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