Counseling for Low Maternal Serum Alpha-Fetoprotein Should Emphasize All Chromosome Anomalies, Not Just Down Syndrome
In common usage, a low maternal serum alpha-fetoprotein (MSAFP) value is associated with an increased risk of Down syndrome. We have performed amniocenteses for the indication of age-adjusted low MSAFP in 1154 patients and found 13 chromosomally abnormal conceptions. Autosomal trisomies were detecte...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1989-02, Vol.73 (2), p.271-274 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
| container_volume | 73 |
| creator | DRUGAN, ARIE DVORIN, ELENA KOPPITCH, FREDERICK C GREB, ANNE KRIVCHENIA, ERIC L EVANS, MARK I |
| description | In common usage, a low maternal serum alpha-fetoprotein (MSAFP) value is associated with an increased risk of Down syndrome. We have performed amniocenteses for the indication of age-adjusted low MSAFP in 1154 patients and found 13 chromosomally abnormal conceptions. Autosomal trisomies were detected in half the cases. Additional abnormalities included sex-chromosome aberrations, deletions, or triploidy in proportions consistent with those seen in an advanced-maternal-age population. Patients with low serum AFP should be counseled that not only Down syndrome, but other aneuploidies as well, may be diagnosed. The risk quoted should be that of all chromosomal abnormalities, which is about twice the risk calculated for Down syndrome. (Obstet Gynecol 73:271, 1989) |
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We have performed amniocenteses for the indication of age-adjusted low MSAFP in 1154 patients and found 13 chromosomally abnormal conceptions. Autosomal trisomies were detected in half the cases. Additional abnormalities included sex-chromosome aberrations, deletions, or triploidy in proportions consistent with those seen in an advanced-maternal-age population. Patients with low serum AFP should be counseled that not only Down syndrome, but other aneuploidies as well, may be diagnosed. The risk quoted should be that of all chromosomal abnormalities, which is about twice the risk calculated for Down syndrome. (Obstet Gynecol 73:271, 1989)</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>PMID: 2463504</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: The American College of Obstetricians and Gynecologists</publisher><subject>Adult ; alpha-Fetoproteins - analysis ; Amniocentesis ; Biological and medical sciences ; Chromosome Aberrations - diagnosis ; Chromosome Disorders ; Down Syndrome - diagnosis ; Female ; Genetic Counseling ; Gynecology. Andrology. Obstetrics ; Humans ; Management. Prenatal diagnosis ; Maternal Age ; Medical sciences ; Pregnancy ; Pregnancy, High-Risk ; Pregnancy. Fetus. 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We have performed amniocenteses for the indication of age-adjusted low MSAFP in 1154 patients and found 13 chromosomally abnormal conceptions. Autosomal trisomies were detected in half the cases. Additional abnormalities included sex-chromosome aberrations, deletions, or triploidy in proportions consistent with those seen in an advanced-maternal-age population. Patients with low serum AFP should be counseled that not only Down syndrome, but other aneuploidies as well, may be diagnosed. The risk quoted should be that of all chromosomal abnormalities, which is about twice the risk calculated for Down syndrome. (Obstet Gynecol 73:271, 1989)</description><subject>Adult</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Amniocentesis</subject><subject>Biological and medical sciences</subject><subject>Chromosome Aberrations - diagnosis</subject><subject>Chromosome Disorders</subject><subject>Down Syndrome - diagnosis</subject><subject>Female</subject><subject>Genetic Counseling</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Management. Prenatal diagnosis</subject><subject>Maternal Age</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy, High-Risk</subject><subject>Pregnancy. Fetus. 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Andrology. Obstetrics</topic><topic>Humans</topic><topic>Management. Prenatal diagnosis</topic><topic>Maternal Age</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy, High-Risk</topic><topic>Pregnancy. Fetus. 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We have performed amniocenteses for the indication of age-adjusted low MSAFP in 1154 patients and found 13 chromosomally abnormal conceptions. Autosomal trisomies were detected in half the cases. Additional abnormalities included sex-chromosome aberrations, deletions, or triploidy in proportions consistent with those seen in an advanced-maternal-age population. Patients with low serum AFP should be counseled that not only Down syndrome, but other aneuploidies as well, may be diagnosed. The risk quoted should be that of all chromosomal abnormalities, which is about twice the risk calculated for Down syndrome. (Obstet Gynecol 73:271, 1989)</abstract><cop>New York, NY</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>2463504</pmid><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0029-7844 |
| ispartof | Obstetrics and gynecology (New York. 1953), 1989-02, Vol.73 (2), p.271-274 |
| issn | 0029-7844 1873-233X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult alpha-Fetoproteins - analysis Amniocentesis Biological and medical sciences Chromosome Aberrations - diagnosis Chromosome Disorders Down Syndrome - diagnosis Female Genetic Counseling Gynecology. Andrology. Obstetrics Humans Management. Prenatal diagnosis Maternal Age Medical sciences Pregnancy Pregnancy, High-Risk Pregnancy. Fetus. Placenta Risk Factors |
| title | Counseling for Low Maternal Serum Alpha-Fetoprotein Should Emphasize All Chromosome Anomalies, Not Just Down Syndrome |
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