Hypothalamic Substance P Release: Attenuated Angiotensin Responses in mRen2(27) Transgenic Rats
Increases in arterial pressure and paraventricular nucleus vasopressin release in response to intracerebroventricular injections of angiotensin peptides are blunted in mRen2(27) renin transgenic [TG(+)] rats. Intraventricular injections of tachykinin peptides mimic several of the actions of angioten...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 1997-01, Vol.29 (1), p.510-513 |
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| container_title | Hypertension (Dallas, Tex. 1979) |
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| creator | Diz, Debra I Falgui, Burt Bosch, Susan M Westwood, Brian M Kent, Jessica Ganten, Detlev Ferrario, Carlos M |
| description | Increases in arterial pressure and paraventricular nucleus vasopressin release in response to intracerebroventricular injections of angiotensin peptides are blunted in mRen2(27) renin transgenic [TG(+)] rats. Intraventricular injections of tachykinin peptides mimic several of the actions of angiotensin peptides, and angiotensin peptides evoke substance P release from hypothalamic brain slices. The present study assessed whether diminished substance P release occurs in response to angiotensin peptides in TG(+) rats. Systolic blood pressure at 8 to 12 weeks of age averaged 197 +/- 4 mm Hg (n = 20; P < .05) in TG(+) rats compared with 123 +/- 4 mm Hg in normotensive control [TG(-)] rats (n = 18). Body weight was lower in hypertensive than in normotensive rats (305 +/- 14 versus 344 +/- 13 g, respectively; P < .05). Brain slices from hypothalamus were perfused at 37 degrees C with oxygenated Krebs' bicarbonate buffer. Substance P was measured before (basal) and during perfusion with either Krebs' buffer (control) or 2 micro mol/L angiotensin-(1-7) or angiotensin II. Basal substance P release was 92 +/- 10 pg/g wet tissue in TG(+) and 98 +/- 12 pg/g in TG(-) rats (P > .05). Angiotensin-(1-7) and angiotensin II significantly increased substance P release from hypothalamus of TG(-) rats (82% and 70% above control; P |
| doi_str_mv | 10.1161/01.hyp.29.1.510 |
| format | Article |
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Intraventricular injections of tachykinin peptides mimic several of the actions of angiotensin peptides, and angiotensin peptides evoke substance P release from hypothalamic brain slices. The present study assessed whether diminished substance P release occurs in response to angiotensin peptides in TG(+) rats. Systolic blood pressure at 8 to 12 weeks of age averaged 197 +/- 4 mm Hg (n = 20; P < .05) in TG(+) rats compared with 123 +/- 4 mm Hg in normotensive control [TG(-)] rats (n = 18). Body weight was lower in hypertensive than in normotensive rats (305 +/- 14 versus 344 +/- 13 g, respectively; P < .05). Brain slices from hypothalamus were perfused at 37 degrees C with oxygenated Krebs' bicarbonate buffer. Substance P was measured before (basal) and during perfusion with either Krebs' buffer (control) or 2 micro mol/L angiotensin-(1-7) or angiotensin II. Basal substance P release was 92 +/- 10 pg/g wet tissue in TG(+) and 98 +/- 12 pg/g in TG(-) rats (P > .05). Angiotensin-(1-7) and angiotensin II significantly increased substance P release from hypothalamus of TG(-) rats (82% and 70% above control; P <.05) but not TG(+) rats. These studies further support the hypothesis that the cardiovascular effects of angiotensin peptides are mediated in part by substance P and that this relationship is blunted in a hypertensive model that results from excess tissue production of angiotensins. (Hypertension. 1997;29[part 2]:510-513.)</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/01.hyp.29.1.510</identifier><identifier>PMID: 9039151</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Angiotensin I ; Angiotensin II - pharmacology ; Animals ; Animals, Genetically Modified ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Experimental diseases ; Hypothalamus - drug effects ; Hypothalamus - metabolism ; Male ; Medical sciences ; Peptide Fragments - pharmacology ; Rats ; Substance P - metabolism ; Vasoconstrictor Agents - pharmacology</subject><ispartof>Hypertension (Dallas, Tex. 1979), 1997-01, Vol.29 (1), p.510-513</ispartof><rights>1997 American Heart Association, Inc.</rights><rights>1997 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Jan 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3880-fb112e598ad2cc31be9588d2ff8fc4e4d9f297b19b71e6f43b4aacb8c174209c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,778,782,787,788,3676,4038,4039,23917,23918,25127,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2600864$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9039151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diz, Debra I</creatorcontrib><creatorcontrib>Falgui, Burt</creatorcontrib><creatorcontrib>Bosch, Susan M</creatorcontrib><creatorcontrib>Westwood, Brian M</creatorcontrib><creatorcontrib>Kent, Jessica</creatorcontrib><creatorcontrib>Ganten, Detlev</creatorcontrib><creatorcontrib>Ferrario, Carlos M</creatorcontrib><title>Hypothalamic Substance P Release: Attenuated Angiotensin Responses in mRen2(27) Transgenic Rats</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Increases in arterial pressure and paraventricular nucleus vasopressin release in response to intracerebroventricular injections of angiotensin peptides are blunted in mRen2(27) renin transgenic [TG(+)] rats. Intraventricular injections of tachykinin peptides mimic several of the actions of angiotensin peptides, and angiotensin peptides evoke substance P release from hypothalamic brain slices. The present study assessed whether diminished substance P release occurs in response to angiotensin peptides in TG(+) rats. Systolic blood pressure at 8 to 12 weeks of age averaged 197 +/- 4 mm Hg (n = 20; P < .05) in TG(+) rats compared with 123 +/- 4 mm Hg in normotensive control [TG(-)] rats (n = 18). Body weight was lower in hypertensive than in normotensive rats (305 +/- 14 versus 344 +/- 13 g, respectively; P < .05). Brain slices from hypothalamus were perfused at 37 degrees C with oxygenated Krebs' bicarbonate buffer. Substance P was measured before (basal) and during perfusion with either Krebs' buffer (control) or 2 micro mol/L angiotensin-(1-7) or angiotensin II. Basal substance P release was 92 +/- 10 pg/g wet tissue in TG(+) and 98 +/- 12 pg/g in TG(-) rats (P > .05). Angiotensin-(1-7) and angiotensin II significantly increased substance P release from hypothalamus of TG(-) rats (82% and 70% above control; P <.05) but not TG(+) rats. These studies further support the hypothesis that the cardiovascular effects of angiotensin peptides are mediated in part by substance P and that this relationship is blunted in a hypertensive model that results from excess tissue production of angiotensins. (Hypertension. 1997;29[part 2]:510-513.)</description><subject>Angiotensin I</subject><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Experimental diseases</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Peptide Fragments - pharmacology</subject><subject>Rats</subject><subject>Substance P - metabolism</subject><subject>Vasoconstrictor Agents - pharmacology</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEFr3DAQhUVpSbdpzz0VTCmlOdjRyLIt9baENhsIJGxTaE9ClsdZp7LseGzC_vuq7JJDBYN4vG8ew2PsPfAMoIRzDtluP2ZCZ5AVwF-wFRRCprIo85dsxUHLVAP8es3eED1wDlLK6oSdaJ5rKGDFzGY_DvPOett3Lvmx1DTb4DC5Tbbo0RJ-TdbzjGGxMzbJOtx3Q1TUhejTOARCSqLotxjEF1GdJXeTDXSPIaZt7Uxv2avWesJ3x_-U_fz-7e5ik17fXF5drK9TlyvF07YGEFhoZRvhXA416kKpRrStap1E2ehW6KoGXVeAZSvzWlrrauWgkoJrl5-yz4fccRoeF6TZ9B059N4GHBYylVJ5KaSO4Mf_wIdhmUK8zQheCFUKVUXo_AC5aSCasDXj1PV22hvg5l_vhoPZ_L41Qhswsfe48eEYu9Q9Ns_8sejofzr6lpz1bWzJdfSMiZJzVcqIyQP2NPgZJ_rjlyeczA6tn3eGxydFqVLQuuIQVRpH8fwvP9OZ_Q</recordid><startdate>199701</startdate><enddate>199701</enddate><creator>Diz, Debra I</creator><creator>Falgui, Burt</creator><creator>Bosch, Susan M</creator><creator>Westwood, Brian M</creator><creator>Kent, Jessica</creator><creator>Ganten, Detlev</creator><creator>Ferrario, Carlos M</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>199701</creationdate><title>Hypothalamic Substance P Release: Attenuated Angiotensin Responses in mRen2(27) Transgenic Rats</title><author>Diz, Debra I ; Falgui, Burt ; Bosch, Susan M ; Westwood, Brian M ; Kent, Jessica ; Ganten, Detlev ; Ferrario, Carlos M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3880-fb112e598ad2cc31be9588d2ff8fc4e4d9f297b19b71e6f43b4aacb8c174209c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Angiotensin I</topic><topic>Angiotensin II - pharmacology</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Experimental diseases</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Peptide Fragments - pharmacology</topic><topic>Rats</topic><topic>Substance P - metabolism</topic><topic>Vasoconstrictor Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Diz, Debra I</creatorcontrib><creatorcontrib>Falgui, Burt</creatorcontrib><creatorcontrib>Bosch, Susan M</creatorcontrib><creatorcontrib>Westwood, Brian M</creatorcontrib><creatorcontrib>Kent, Jessica</creatorcontrib><creatorcontrib>Ganten, Detlev</creatorcontrib><creatorcontrib>Ferrario, Carlos M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diz, Debra I</au><au>Falgui, Burt</au><au>Bosch, Susan M</au><au>Westwood, Brian M</au><au>Kent, Jessica</au><au>Ganten, Detlev</au><au>Ferrario, Carlos M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypothalamic Substance P Release: Attenuated Angiotensin Responses in mRen2(27) Transgenic Rats</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>1997-01</date><risdate>1997</risdate><volume>29</volume><issue>1</issue><spage>510</spage><epage>513</epage><pages>510-513</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>Increases in arterial pressure and paraventricular nucleus vasopressin release in response to intracerebroventricular injections of angiotensin peptides are blunted in mRen2(27) renin transgenic [TG(+)] rats. Intraventricular injections of tachykinin peptides mimic several of the actions of angiotensin peptides, and angiotensin peptides evoke substance P release from hypothalamic brain slices. The present study assessed whether diminished substance P release occurs in response to angiotensin peptides in TG(+) rats. Systolic blood pressure at 8 to 12 weeks of age averaged 197 +/- 4 mm Hg (n = 20; P < .05) in TG(+) rats compared with 123 +/- 4 mm Hg in normotensive control [TG(-)] rats (n = 18). Body weight was lower in hypertensive than in normotensive rats (305 +/- 14 versus 344 +/- 13 g, respectively; P < .05). Brain slices from hypothalamus were perfused at 37 degrees C with oxygenated Krebs' bicarbonate buffer. Substance P was measured before (basal) and during perfusion with either Krebs' buffer (control) or 2 micro mol/L angiotensin-(1-7) or angiotensin II. Basal substance P release was 92 +/- 10 pg/g wet tissue in TG(+) and 98 +/- 12 pg/g in TG(-) rats (P > .05). Angiotensin-(1-7) and angiotensin II significantly increased substance P release from hypothalamus of TG(-) rats (82% and 70% above control; P <.05) but not TG(+) rats. These studies further support the hypothesis that the cardiovascular effects of angiotensin peptides are mediated in part by substance P and that this relationship is blunted in a hypertensive model that results from excess tissue production of angiotensins. (Hypertension. 1997;29[part 2]:510-513.)</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>9039151</pmid><doi>10.1161/01.hyp.29.1.510</doi><tpages>4</tpages></addata></record> |
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| ispartof | Hypertension (Dallas, Tex. 1979), 1997-01, Vol.29 (1), p.510-513 |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload |
| subjects | Angiotensin I Angiotensin II - pharmacology Animals Animals, Genetically Modified Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Experimental diseases Hypothalamus - drug effects Hypothalamus - metabolism Male Medical sciences Peptide Fragments - pharmacology Rats Substance P - metabolism Vasoconstrictor Agents - pharmacology |
| title | Hypothalamic Substance P Release: Attenuated Angiotensin Responses in mRen2(27) Transgenic Rats |
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