Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit

A common feature of general anaesthetic agents is their ability to potentiate neuronal inhibition through GABA(A) (gamma-aminobutyric acid) receptors. At concentrations relevant to clinical anaesthesia, these agents cause a dramatic stimulation of the chloride currents that are evoked by the binding...

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Veröffentlicht in:	Nature (London) 1997-02, Vol.385 (6619), p.820-823
Hauptverfasser:	Davies, P A, Hanna, M C, Hales, T G, Kirkness, E F
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anesthetics, Intravenous - pharmacology Animals Bicuculline - pharmacology Brain - metabolism Cell Line Consensus Sequence DNA, Complementary Flumazenil - pharmacology Flunitrazepam - pharmacology GABA Agents - pharmacology gamma-Aminobutyric Acid - pharmacology Humans Molecular Sequence Data Muscimol - metabolism Pentobarbital - pharmacology Picrotoxin - pharmacology Pregnanolone - pharmacology Propofol - pharmacology Rats Receptors, GABA-A - chemistry Receptors, GABA-A - drug effects Receptors, GABA-A - genetics Recombinant Proteins - chemistry Recombinant Proteins - drug effects Recombinant Proteins - genetics RNA, Messenger - metabolism Transfection
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