Diltiazem and Mortality and Reinfarction after Myocardial Infarction

Diltiazem and Mortality and Reinfarction after Myocardial Infarction

To the Editor: The Multicenter Diltiazem Postinfarction Trial Research Group (Aug. 18 issue)1 reported no overall effect of diltiazem on cardiac events and mortality in a randomized trial in 2466 patients with previous infarction. The authors suggested that this lack of superiority to placebo may ha...

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Veröffentlicht in:The New England journal of medicine 1989-01, Vol.320 (2), p.123-124
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Sprache:eng
Schlagworte:
Diltiazem - therapeutic use
Humans
Myocardial Infarction - drug therapy
Myocardial Infarction - mortality
Recurrence
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container_title The New England journal of medicine
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description To the Editor: The Multicenter Diltiazem Postinfarction Trial Research Group (Aug. 18 issue)1 reported no overall effect of diltiazem on cardiac events and mortality in a randomized trial in 2466 patients with previous infarction. The authors suggested that this lack of superiority to placebo may have been due to an apparently striking (P = 0.0042) bidirectional effect, depending on the presence of left ventricular dysfunction. Although they are cautious in the analysis and interpretation of the trial, they nevertheless state that these data constitute "strong evidence" of a treatment-by-subset interaction and finally conclude ambiguously that "diltiazem is not appropriate for . . .
doi_str_mv 10.1056/NEJM198901123200212
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subjects Diltiazem - therapeutic use
Humans
Myocardial Infarction - drug therapy
Myocardial Infarction - mortality
Recurrence
title Diltiazem and Mortality and Reinfarction after Myocardial Infarction
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