Time-dependent influence of the somatostatin analogue octreotide on the proliferation of rat astrocytes and glioma cells
The somatostatin receptor subtype sst 2 was visualized by immunostaining on cultivated rat astrocytes and C6 rat glioma cells. Octreotide, a metabolically stable sst 2 agonist reduced [ 3H]thymidine incorporation into DNA of both cell types dose-dependently only after short-time application (2–5 h),...
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| Veröffentlicht in: | Brain research 1997-01, Vol.746 (1), p.309-313 |
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| container_title | Brain research |
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| creator | Feindt, Janka Mentlein, Rolf Krisch, Brigitte |
| description | The somatostatin receptor subtype sst
2 was visualized by immunostaining on cultivated rat astrocytes and C6 rat glioma cells. Octreotide, a metabolically stable sst
2 agonist reduced [
3H]thymidine incorporation into DNA of both cell types dose-dependently only after short-time application (2–5 h), after prolonged incubation (>12 h) no antiproliferative effect was measurable. We conclude that sst
2 receptors may be desensitized. Thus, desensitization might hinder application of octreotide to reduce glial tumour growth. |
| doi_str_mv | 10.1016/S0006-8993(96)01312-1 |
| format | Article |
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2 was visualized by immunostaining on cultivated rat astrocytes and C6 rat glioma cells. Octreotide, a metabolically stable sst
2 agonist reduced [
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| ispartof | Brain research, 1997-01, Vol.746 (1), p.309-313 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amino Acid Sequence Animals Astrocytes - cytology Astrocytes - drug effects Cell Division - drug effects Desensitization Glial cell Glioma Hormones - pharmacology Immunohistochemistry Immunostaining Molecular Sequence Data Octreotide Octreotide - pharmacology Proliferation Rats Rats, Wistar Somatostatin - analogs & derivatives Somatostatin receptor Time Factors Tumor Cells, Cultured - cytology Tumor Cells, Cultured - drug effects |
| title | Time-dependent influence of the somatostatin analogue octreotide on the proliferation of rat astrocytes and glioma cells |
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