Thyroid hormones and the hepatic handling of bilirubin. I. Effects of hypothyroidism and hyperthyroidism on the hepatic transport of bilirubin mono‐ and diconjugates in the wistar rat

The effects of thyroidectomy and of thyroid hormone administration on the hepatic transport of endogenous bilirubin were investigated in the Wistar R/APfd rat. Hypothyroidism resulted in an enhanced hepatic bilirubin UDP‐glucuronosyltransferase activity and in a decreased p‐nitrophenol transferase a...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 1989-02, Vol.9 (2), p.314-321
Hauptverfasser:	Van Steenbergen, Werner, Fevery, Johan, De Vos, Rita, Leyten, Roger, Heirwegh, Karel P. M., De Groote, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Nitrophenylphosphatase - metabolism Animals Bile - metabolism Bile Acids and Salts - metabolism Bilirubin - analogs & derivatives Bilirubin - metabolism Biological and medical sciences Biological Transport Electrolytes - metabolism Fundamental and applied biological sciences. Psychology Glucuronidase - metabolism Glucuronosyltransferase - metabolism Hyperthyroidism - metabolism Hypothyroidism - metabolism Liver - drug effects Liver - metabolism Liver - ultrastructure Liver. Bile. Biliary tracts Male Microscopy, Electron Phospholipids - metabolism Rats Rats, Inbred Strains Thyroid Hormones - physiology Thyroidectomy Thyroxine - pharmacology Vertebrates: digestive system
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