Synthesis and Biological Evaluation of a New Reversely Linked Type of Dual Histamine H2 and Gastrin Receptor Antagonist

In an attempt to improve the low oral absorbability of previously reported dual histamine H2 and gastrin receptor antagonists, compounds of a different type were synthesized and evaluated for biological activity. These new compounds bear a histamine H2 receptor antagonist (H2A) pharmacophore moiety...

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Veröffentlicht in:Chemical & pharmaceutical bulletin 1997/01/15, Vol.45(1), pp.116-124
Hauptverfasser: KAWANISHI, Yasuyuki, ISHIHARA, Shoichi, TAKAHASHI, Kimio, TSUSHIMA, Tadahiko, HAGISHITA, Sanji, ISHIKAWA, Michio, ISHIHARA, Yasunobu
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Sprache:eng
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