Tissue distribution and metabolism in rat of an ethynesulphonamide with filaricidal activity

1. The tissue distribution and metabolism of a new filaricidal agent P903 (N -\[(2- phenylethynyl)sulfonyl]morpholine) were studied in rat. 2. After s.c. administration of C and C P903, the Tmax in the bloodwas observed on day 2. Elimination was slow and 95% was bound to protein. Radioactivity was d...

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Veröffentlicht in:	Xenobiotica 1997, Vol.27 (1), p.73-85
Hauptverfasser:	Radembino, N., Dessalles, M.- C., Trouvin, J.-H., Loiseau, P. M., Gayral, P., Mahuzier, G., Rapp, M., Labarre, P., Godeneche, D., Madelmont, J.-C., Maurizis, J.-C., Veyre, A., Chabard, J.-L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biological and medical sciences Chromatography, High Pressure Liquid Filaricides - blood Filaricides - metabolism Filaricides - pharmacokinetics Filaricides - urine Kinetics Magnetic Resonance Spectroscopy Male Mass Spectrometry Medical sciences Pharmacology. Drug treatments Protein Binding Rats Rats, Sprague-Dawley Scintillation Counting Sulfonamides - blood Sulfonamides - metabolism Sulfonamides - pharmacokinetics Sulfonamides - urine Tissue Distribution
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