Arrhythmogenicity of IgG and Anti-52-kD SSA/Ro Affinity-Purified Antibodies From Mothers of Children With Congenital Heart Block

An important advance in the description and understanding of congenital heart block (CHB) came in the 1970s with the observation that mothers of affected infants frequently had autoimmune diseases and, in particular, that many maternal sera contained antibodies to SSA/Ro and SSB/La ribonucleoprotein...

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Veröffentlicht in:	Circulation research 1997-03, Vol.80 (3), p.354-362
Hauptverfasser:	Boutjdir, Mohamed, Chen, Long, Zhang, Zhi-Hao, Tseng, Chung-E, DiDonato, Francis, Rashbaum, William, Morris, Alan, El-Sherif, Nabil, Buyon, Jill P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Autoantibodies - pharmacology Autoantigens - immunology Autoantigens - pharmacology Biological and medical sciences Bradycardia - immunology Cardiac dysrhythmias Cardiology. Vascular system Cells, Cultured Electrocardiography Female Heart Heart Block - congenital Heart Block - etiology Humans Immunoglobulin G - pharmacology In Vitro Techniques Male Maternal-Fetal Exchange Medical sciences Mice Mice, Inbred BALB C Patch-Clamp Techniques Pregnancy Ribonucleoproteins - immunology Ribonucleoproteins - pharmacology RNA, Small Cytoplasmic
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