Proline‐incorporating cells in chronic active liver diseases
The incorporation of 3H‐proline in cells of liver biopsy specimens from patients with chronic active liver diseases has been studied by light and electron microscopic autoradiography. The labeled proline is incorporated by hepatocytes of the external rows of the residual liver lobule, by the cells o...
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Veröffentlicht in: | Hepatology (Baltimore, Md.) Md.), 1989-01, Vol.9 (1), p.37-49 |
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creator | Hassan, Giorgio Stefanini, Stefania Bargagli, Anna Maria Autuori, Francesco |
description | The incorporation of 3H‐proline in cells of liver biopsy specimens from patients with chronic active liver diseases has been studied by light and electron microscopic autoradiography. The labeled proline is incorporated by hepatocytes of the external rows of the residual liver lobule, by the cells of the proliferating bile ductule and very actively by the plasma cells localized at the boundary between the inflammatory infiltrate and the liver lobule. These plasma cells, which are often in close contact with the hepatocytes at the edge of the liver lobule, appear to be either negative or positive after the immunohistochemical tests for the k and λ chains of immunoglobulins. Results are discussed in relation to both the synthesis of collagen and the role of the immunocompetent cells during the process of the piecemeal necrosis. |
doi_str_mv | 10.1002/hep.1840090107 |
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The labeled proline is incorporated by hepatocytes of the external rows of the residual liver lobule, by the cells of the proliferating bile ductule and very actively by the plasma cells localized at the boundary between the inflammatory infiltrate and the liver lobule. These plasma cells, which are often in close contact with the hepatocytes at the edge of the liver lobule, appear to be either negative or positive after the immunohistochemical tests for the k and λ chains of immunoglobulins. Results are discussed in relation to both the synthesis of collagen and the role of the immunocompetent cells during the process of the piecemeal necrosis.</description><identifier>ISSN: 0270-9139</identifier><identifier>EISSN: 1527-3350</identifier><identifier>DOI: 10.1002/hep.1840090107</identifier><identifier>PMID: 2908868</identifier><identifier>CODEN: HPTLD9</identifier><language>eng</language><publisher>Philadelphia, PA: W.B. Saunders</publisher><subject>Autoradiography ; Biological and medical sciences ; Biopsy ; Collagen - biosynthesis ; Connective Tissue - metabolism ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis, Chronic - metabolism ; Hepatitis, Chronic - pathology ; Humans ; Immunoglobulins - biosynthesis ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Microscopy, Electron ; Necrosis ; Other diseases. Semiology ; Plasma Cells - metabolism ; Proline - metabolism</subject><ispartof>Hepatology (Baltimore, Md.), 1989-01, Vol.9 (1), p.37-49</ispartof><rights>Copyright © 1989 American Association for the Study of Liver Diseases</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4097-e06976ebe309e00a00d1128484229465d662927863113777159db043a821e0fe3</citedby><cites>FETCH-LOGICAL-c4097-e06976ebe309e00a00d1128484229465d662927863113777159db043a821e0fe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhep.1840090107$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhep.1840090107$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,4022,27922,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7147040$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2908868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hassan, Giorgio</creatorcontrib><creatorcontrib>Stefanini, Stefania</creatorcontrib><creatorcontrib>Bargagli, Anna Maria</creatorcontrib><creatorcontrib>Autuori, Francesco</creatorcontrib><title>Proline‐incorporating cells in chronic active liver diseases</title><title>Hepatology (Baltimore, Md.)</title><addtitle>Hepatology</addtitle><description>The incorporation of 3H‐proline in cells of liver biopsy specimens from patients with chronic active liver diseases has been studied by light and electron microscopic autoradiography. The labeled proline is incorporated by hepatocytes of the external rows of the residual liver lobule, by the cells of the proliferating bile ductule and very actively by the plasma cells localized at the boundary between the inflammatory infiltrate and the liver lobule. These plasma cells, which are often in close contact with the hepatocytes at the edge of the liver lobule, appear to be either negative or positive after the immunohistochemical tests for the k and λ chains of immunoglobulins. Results are discussed in relation to both the synthesis of collagen and the role of the immunocompetent cells during the process of the piecemeal necrosis.</description><subject>Autoradiography</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Collagen - biosynthesis</subject><subject>Connective Tissue - metabolism</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis, Chronic - metabolism</subject><subject>Hepatitis, Chronic - pathology</subject><subject>Humans</subject><subject>Immunoglobulins - biosynthesis</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Necrosis</subject><subject>Other diseases. 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Abdomen</topic><topic>Hepatitis, Chronic - metabolism</topic><topic>Hepatitis, Chronic - pathology</topic><topic>Humans</topic><topic>Immunoglobulins - biosynthesis</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Necrosis</topic><topic>Other diseases. Semiology</topic><topic>Plasma Cells - metabolism</topic><topic>Proline - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hassan, Giorgio</creatorcontrib><creatorcontrib>Stefanini, Stefania</creatorcontrib><creatorcontrib>Bargagli, Anna Maria</creatorcontrib><creatorcontrib>Autuori, Francesco</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hassan, Giorgio</au><au>Stefanini, Stefania</au><au>Bargagli, Anna Maria</au><au>Autuori, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proline‐incorporating cells in chronic active liver diseases</atitle><jtitle>Hepatology (Baltimore, Md.)</jtitle><addtitle>Hepatology</addtitle><date>1989-01</date><risdate>1989</risdate><volume>9</volume><issue>1</issue><spage>37</spage><epage>49</epage><pages>37-49</pages><issn>0270-9139</issn><eissn>1527-3350</eissn><coden>HPTLD9</coden><abstract>The incorporation of 3H‐proline in cells of liver biopsy specimens from patients with chronic active liver diseases has been studied by light and electron microscopic autoradiography. The labeled proline is incorporated by hepatocytes of the external rows of the residual liver lobule, by the cells of the proliferating bile ductule and very actively by the plasma cells localized at the boundary between the inflammatory infiltrate and the liver lobule. These plasma cells, which are often in close contact with the hepatocytes at the edge of the liver lobule, appear to be either negative or positive after the immunohistochemical tests for the k and λ chains of immunoglobulins. Results are discussed in relation to both the synthesis of collagen and the role of the immunocompetent cells during the process of the piecemeal necrosis.</abstract><cop>Philadelphia, PA</cop><pub>W.B. Saunders</pub><pmid>2908868</pmid><doi>10.1002/hep.1840090107</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Autoradiography Biological and medical sciences Biopsy Collagen - biosynthesis Connective Tissue - metabolism Gastroenterology. Liver. Pancreas. Abdomen Hepatitis, Chronic - metabolism Hepatitis, Chronic - pathology Humans Immunoglobulins - biosynthesis Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Microscopy, Electron Necrosis Other diseases. Semiology Plasma Cells - metabolism Proline - metabolism |
title | Proline‐incorporating cells in chronic active liver diseases |
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