Dexamethasone and cyclosporin A modulation of human retinal pigment epithelial cell monocyte chemotactic protein-1 and interleukin-8

To examine the modulation of interleukin-1 beta (IL-1 beta)- and tumor necrosis factor-alpha (TNF-alpha)-stimulated monocyte chemotactic protein-1 (MCP-1) and interleukin-8 (IL-8) secretion and transcription in human retinal pigment epithelial (HRPE) cells by dexamethasone (DEX) and cyclosporin A (C...

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Veröffentlicht in:	Investigative ophthalmology & visual science 1997-02, Vol.38 (2), p.436-445
Hauptverfasser:	Kurtz, RM, Elner, VM, Bian, ZM, Strieter, RM, Kunkel, SL, Elner, SG
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - pharmacology Biological and medical sciences Blotting, Northern Cells, Cultured Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Cyclosporine - pharmacology Dexamethasone - pharmacology DNA Probes - chemistry Dose-Response Relationship, Drug Enzyme-Linked Immunosorbent Assay Eye Humans Immunosuppressive Agents - pharmacology Interleukin-1 - antagonists & inhibitors Interleukin-1 - pharmacology Interleukin-8 - genetics Interleukin-8 - metabolism Medical sciences Pharmacology. Drug treatments Pigment Epithelium of Eye - drug effects Pigment Epithelium of Eye - metabolism RNA, Messenger - metabolism Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - pharmacology
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