The effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of metoprolol
SUMMARY The impact of cimetidine, ranitidine and placebo on the pharmacokinetics of metoprolol, given either as a single dose (100 mg) or for 7 days (100 mg b.d.), has been evaluated in two separate studies. The doses used were 800 mg cimetidine daily and 300 mg ranitidine daily. The subjects were a...
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Veröffentlicht in: | Alimentary pharmacology & therapeutics 1988-12, Vol.2 (6), p.521-527 |
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creator | CHELLINGSWORTH, M. C. LAUGHER, S. AKHLAGHI, S. JACK, D. B. KENDALL, M. J. |
description | SUMMARY
The impact of cimetidine, ranitidine and placebo on the pharmacokinetics of metoprolol, given either as a single dose (100 mg) or for 7 days (100 mg b.d.), has been evaluated in two separate studies. The doses used were 800 mg cimetidine daily and 300 mg ranitidine daily. The subjects were all young, healthy volunteers. In the single dose study, cimetidine produced a marked increase in the peak plasma concentration of metoprolol and in the area under the plasma concentration‐time curve; ranitidine had less effect, though the area under the curve was significantly greater than placebo. In the chronic dosing study, the area under the curve for metoprolol was also significantly higher on cimetidine (1796 ng h/ml; P < 0.001) whereas the area under the curve on ranitidine (1258 ng h/ml) was comparable to that on placebo (1183 ng h/ml). Despite these drug‐induced changes in plasma metoprolol concentration, neither cimetidine nor ranitidine altered the change in exercise‐induced heart rate during dosing with metoprolol. |
doi_str_mv | 10.1111/j.1365-2036.1988.tb00726.x |
format | Article |
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The impact of cimetidine, ranitidine and placebo on the pharmacokinetics of metoprolol, given either as a single dose (100 mg) or for 7 days (100 mg b.d.), has been evaluated in two separate studies. The doses used were 800 mg cimetidine daily and 300 mg ranitidine daily. The subjects were all young, healthy volunteers. In the single dose study, cimetidine produced a marked increase in the peak plasma concentration of metoprolol and in the area under the plasma concentration‐time curve; ranitidine had less effect, though the area under the curve was significantly greater than placebo. In the chronic dosing study, the area under the curve for metoprolol was also significantly higher on cimetidine (1796 ng h/ml; P < 0.001) whereas the area under the curve on ranitidine (1258 ng h/ml) was comparable to that on placebo (1183 ng h/ml). Despite these drug‐induced changes in plasma metoprolol concentration, neither cimetidine nor ranitidine altered the change in exercise‐induced heart rate during dosing with metoprolol.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.1988.tb00726.x</identifier><identifier>PMID: 2979275</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Cimetidine - pharmacology ; Female ; Humans ; Male ; Metoprolol - pharmacokinetics ; Ranitidine - pharmacology ; Single-Blind Method</subject><ispartof>Alimentary pharmacology & therapeutics, 1988-12, Vol.2 (6), p.521-527</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2841-713517f3e6479f325689791c7552d7fa6a3e69dee256b7babba24ff3776816623</citedby><cites>FETCH-LOGICAL-c2841-713517f3e6479f325689791c7552d7fa6a3e69dee256b7babba24ff3776816623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2036.1988.tb00726.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2036.1988.tb00726.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2979275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHELLINGSWORTH, M. C.</creatorcontrib><creatorcontrib>LAUGHER, S.</creatorcontrib><creatorcontrib>AKHLAGHI, S.</creatorcontrib><creatorcontrib>JACK, D. B.</creatorcontrib><creatorcontrib>KENDALL, M. J.</creatorcontrib><title>The effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of metoprolol</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>SUMMARY
The impact of cimetidine, ranitidine and placebo on the pharmacokinetics of metoprolol, given either as a single dose (100 mg) or for 7 days (100 mg b.d.), has been evaluated in two separate studies. The doses used were 800 mg cimetidine daily and 300 mg ranitidine daily. The subjects were all young, healthy volunteers. In the single dose study, cimetidine produced a marked increase in the peak plasma concentration of metoprolol and in the area under the plasma concentration‐time curve; ranitidine had less effect, though the area under the curve was significantly greater than placebo. In the chronic dosing study, the area under the curve for metoprolol was also significantly higher on cimetidine (1796 ng h/ml; P < 0.001) whereas the area under the curve on ranitidine (1258 ng h/ml) was comparable to that on placebo (1183 ng h/ml). Despite these drug‐induced changes in plasma metoprolol concentration, neither cimetidine nor ranitidine altered the change in exercise‐induced heart rate during dosing with metoprolol.</description><subject>Adult</subject><subject>Cimetidine - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Metoprolol - pharmacokinetics</subject><subject>Ranitidine - pharmacology</subject><subject>Single-Blind Method</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUEtPwyAAJkYz5_QnmDQevLXyWIF6MFkWX8kSPcwzoRQyZlsmdHH791JXd5cL4XuSD4AbBDMUz906Q4TmKYaEZqjgPOtKCBmm2e4EjI_UKRhDTIsUc0TOwUUIawghZRCPwAgXrMAsHwO1XOlEG6NVFxJnEi9b29nKtjqRbZUo2-jh6dqki9rNSvpGKvcZsc6q8Cv7A6t9K5sejEnR6Dbe1a6-BGdG1kFfDfcEfDw9Lucv6eLt-XU-W6QK8ylKGSI5YoZoOmWFITinPP4SKZbnuGJGUhmpotI6MiUrZVlKPDWGMEY5ohSTCbg95Mbar60OnWhsULquZavdNgjGOY4lJArvD0LlXQheG7HxtpF-LxAU_cJiLfoZRT-j6BcWw8JiF83XQ8u2bHR1tA6TRv7hwH_bWu__kSxm78scI_ID6A2MVA</recordid><startdate>198812</startdate><enddate>198812</enddate><creator>CHELLINGSWORTH, M. C.</creator><creator>LAUGHER, S.</creator><creator>AKHLAGHI, S.</creator><creator>JACK, D. B.</creator><creator>KENDALL, M. J.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198812</creationdate><title>The effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of metoprolol</title><author>CHELLINGSWORTH, M. C. ; LAUGHER, S. ; AKHLAGHI, S. ; JACK, D. B. ; KENDALL, M. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2841-713517f3e6479f325689791c7552d7fa6a3e69dee256b7babba24ff3776816623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Cimetidine - pharmacology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Metoprolol - pharmacokinetics</topic><topic>Ranitidine - pharmacology</topic><topic>Single-Blind Method</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHELLINGSWORTH, M. C.</creatorcontrib><creatorcontrib>LAUGHER, S.</creatorcontrib><creatorcontrib>AKHLAGHI, S.</creatorcontrib><creatorcontrib>JACK, D. B.</creatorcontrib><creatorcontrib>KENDALL, M. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHELLINGSWORTH, M. C.</au><au>LAUGHER, S.</au><au>AKHLAGHI, S.</au><au>JACK, D. B.</au><au>KENDALL, M. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of metoprolol</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>1988-12</date><risdate>1988</risdate><volume>2</volume><issue>6</issue><spage>521</spage><epage>527</epage><pages>521-527</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>SUMMARY
The impact of cimetidine, ranitidine and placebo on the pharmacokinetics of metoprolol, given either as a single dose (100 mg) or for 7 days (100 mg b.d.), has been evaluated in two separate studies. The doses used were 800 mg cimetidine daily and 300 mg ranitidine daily. The subjects were all young, healthy volunteers. In the single dose study, cimetidine produced a marked increase in the peak plasma concentration of metoprolol and in the area under the plasma concentration‐time curve; ranitidine had less effect, though the area under the curve was significantly greater than placebo. In the chronic dosing study, the area under the curve for metoprolol was also significantly higher on cimetidine (1796 ng h/ml; P < 0.001) whereas the area under the curve on ranitidine (1258 ng h/ml) was comparable to that on placebo (1183 ng h/ml). Despite these drug‐induced changes in plasma metoprolol concentration, neither cimetidine nor ranitidine altered the change in exercise‐induced heart rate during dosing with metoprolol.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2979275</pmid><doi>10.1111/j.1365-2036.1988.tb00726.x</doi><tpages>7</tpages></addata></record> |
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source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
subjects | Adult Cimetidine - pharmacology Female Humans Male Metoprolol - pharmacokinetics Ranitidine - pharmacology Single-Blind Method |
title | The effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of metoprolol |
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