The effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of metoprolol

SUMMARY The impact of cimetidine, ranitidine and placebo on the pharmacokinetics of metoprolol, given either as a single dose (100 mg) or for 7 days (100 mg b.d.), has been evaluated in two separate studies. The doses used were 800 mg cimetidine daily and 300 mg ranitidine daily. The subjects were a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Alimentary pharmacology & therapeutics 1988-12, Vol.2 (6), p.521-527
Hauptverfasser: CHELLINGSWORTH, M. C., LAUGHER, S., AKHLAGHI, S., JACK, D. B., KENDALL, M. J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 527
container_issue 6
container_start_page 521
container_title Alimentary pharmacology & therapeutics
container_volume 2
creator CHELLINGSWORTH, M. C.
LAUGHER, S.
AKHLAGHI, S.
JACK, D. B.
KENDALL, M. J.
description SUMMARY The impact of cimetidine, ranitidine and placebo on the pharmacokinetics of metoprolol, given either as a single dose (100 mg) or for 7 days (100 mg b.d.), has been evaluated in two separate studies. The doses used were 800 mg cimetidine daily and 300 mg ranitidine daily. The subjects were all young, healthy volunteers. In the single dose study, cimetidine produced a marked increase in the peak plasma concentration of metoprolol and in the area under the plasma concentration‐time curve; ranitidine had less effect, though the area under the curve was significantly greater than placebo. In the chronic dosing study, the area under the curve for metoprolol was also significantly higher on cimetidine (1796 ng h/ml; P < 0.001) whereas the area under the curve on ranitidine (1258 ng h/ml) was comparable to that on placebo (1183 ng h/ml). Despite these drug‐induced changes in plasma metoprolol concentration, neither cimetidine nor ranitidine altered the change in exercise‐induced heart rate during dosing with metoprolol.
doi_str_mv 10.1111/j.1365-2036.1988.tb00726.x
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78827133</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78827133</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2841-713517f3e6479f325689791c7552d7fa6a3e69dee256b7babba24ff3776816623</originalsourceid><addsrcrecordid>eNqVUEtPwyAAJkYz5_QnmDQevLXyWIF6MFkWX8kSPcwzoRQyZlsmdHH791JXd5cL4XuSD4AbBDMUz906Q4TmKYaEZqjgPOtKCBmm2e4EjI_UKRhDTIsUc0TOwUUIawghZRCPwAgXrMAsHwO1XOlEG6NVFxJnEi9b29nKtjqRbZUo2-jh6dqki9rNSvpGKvcZsc6q8Cv7A6t9K5sejEnR6Dbe1a6-BGdG1kFfDfcEfDw9Lucv6eLt-XU-W6QK8ylKGSI5YoZoOmWFITinPP4SKZbnuGJGUhmpotI6MiUrZVlKPDWGMEY5ohSTCbg95Mbar60OnWhsULquZavdNgjGOY4lJArvD0LlXQheG7HxtpF-LxAU_cJiLfoZRT-j6BcWw8JiF83XQ8u2bHR1tA6TRv7hwH_bWu__kSxm78scI_ID6A2MVA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78827133</pqid></control><display><type>article</type><title>The effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of metoprolol</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>CHELLINGSWORTH, M. C. ; LAUGHER, S. ; AKHLAGHI, S. ; JACK, D. B. ; KENDALL, M. J.</creator><creatorcontrib>CHELLINGSWORTH, M. C. ; LAUGHER, S. ; AKHLAGHI, S. ; JACK, D. B. ; KENDALL, M. J.</creatorcontrib><description>SUMMARY The impact of cimetidine, ranitidine and placebo on the pharmacokinetics of metoprolol, given either as a single dose (100 mg) or for 7 days (100 mg b.d.), has been evaluated in two separate studies. The doses used were 800 mg cimetidine daily and 300 mg ranitidine daily. The subjects were all young, healthy volunteers. In the single dose study, cimetidine produced a marked increase in the peak plasma concentration of metoprolol and in the area under the plasma concentration‐time curve; ranitidine had less effect, though the area under the curve was significantly greater than placebo. In the chronic dosing study, the area under the curve for metoprolol was also significantly higher on cimetidine (1796 ng h/ml; P &lt; 0.001) whereas the area under the curve on ranitidine (1258 ng h/ml) was comparable to that on placebo (1183 ng h/ml). Despite these drug‐induced changes in plasma metoprolol concentration, neither cimetidine nor ranitidine altered the change in exercise‐induced heart rate during dosing with metoprolol.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.1988.tb00726.x</identifier><identifier>PMID: 2979275</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Cimetidine - pharmacology ; Female ; Humans ; Male ; Metoprolol - pharmacokinetics ; Ranitidine - pharmacology ; Single-Blind Method</subject><ispartof>Alimentary pharmacology &amp; therapeutics, 1988-12, Vol.2 (6), p.521-527</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2841-713517f3e6479f325689791c7552d7fa6a3e69dee256b7babba24ff3776816623</citedby><cites>FETCH-LOGICAL-c2841-713517f3e6479f325689791c7552d7fa6a3e69dee256b7babba24ff3776816623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2036.1988.tb00726.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2036.1988.tb00726.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2979275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHELLINGSWORTH, M. C.</creatorcontrib><creatorcontrib>LAUGHER, S.</creatorcontrib><creatorcontrib>AKHLAGHI, S.</creatorcontrib><creatorcontrib>JACK, D. B.</creatorcontrib><creatorcontrib>KENDALL, M. J.</creatorcontrib><title>The effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of metoprolol</title><title>Alimentary pharmacology &amp; therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>SUMMARY The impact of cimetidine, ranitidine and placebo on the pharmacokinetics of metoprolol, given either as a single dose (100 mg) or for 7 days (100 mg b.d.), has been evaluated in two separate studies. The doses used were 800 mg cimetidine daily and 300 mg ranitidine daily. The subjects were all young, healthy volunteers. In the single dose study, cimetidine produced a marked increase in the peak plasma concentration of metoprolol and in the area under the plasma concentration‐time curve; ranitidine had less effect, though the area under the curve was significantly greater than placebo. In the chronic dosing study, the area under the curve for metoprolol was also significantly higher on cimetidine (1796 ng h/ml; P &lt; 0.001) whereas the area under the curve on ranitidine (1258 ng h/ml) was comparable to that on placebo (1183 ng h/ml). Despite these drug‐induced changes in plasma metoprolol concentration, neither cimetidine nor ranitidine altered the change in exercise‐induced heart rate during dosing with metoprolol.</description><subject>Adult</subject><subject>Cimetidine - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Metoprolol - pharmacokinetics</subject><subject>Ranitidine - pharmacology</subject><subject>Single-Blind Method</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVUEtPwyAAJkYz5_QnmDQevLXyWIF6MFkWX8kSPcwzoRQyZlsmdHH791JXd5cL4XuSD4AbBDMUz906Q4TmKYaEZqjgPOtKCBmm2e4EjI_UKRhDTIsUc0TOwUUIawghZRCPwAgXrMAsHwO1XOlEG6NVFxJnEi9b29nKtjqRbZUo2-jh6dqki9rNSvpGKvcZsc6q8Cv7A6t9K5sejEnR6Dbe1a6-BGdG1kFfDfcEfDw9Lucv6eLt-XU-W6QK8ylKGSI5YoZoOmWFITinPP4SKZbnuGJGUhmpotI6MiUrZVlKPDWGMEY5ohSTCbg95Mbar60OnWhsULquZavdNgjGOY4lJArvD0LlXQheG7HxtpF-LxAU_cJiLfoZRT-j6BcWw8JiF83XQ8u2bHR1tA6TRv7hwH_bWu__kSxm78scI_ID6A2MVA</recordid><startdate>198812</startdate><enddate>198812</enddate><creator>CHELLINGSWORTH, M. C.</creator><creator>LAUGHER, S.</creator><creator>AKHLAGHI, S.</creator><creator>JACK, D. B.</creator><creator>KENDALL, M. J.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198812</creationdate><title>The effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of metoprolol</title><author>CHELLINGSWORTH, M. C. ; LAUGHER, S. ; AKHLAGHI, S. ; JACK, D. B. ; KENDALL, M. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2841-713517f3e6479f325689791c7552d7fa6a3e69dee256b7babba24ff3776816623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Cimetidine - pharmacology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Metoprolol - pharmacokinetics</topic><topic>Ranitidine - pharmacology</topic><topic>Single-Blind Method</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHELLINGSWORTH, M. C.</creatorcontrib><creatorcontrib>LAUGHER, S.</creatorcontrib><creatorcontrib>AKHLAGHI, S.</creatorcontrib><creatorcontrib>JACK, D. B.</creatorcontrib><creatorcontrib>KENDALL, M. J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology &amp; therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHELLINGSWORTH, M. C.</au><au>LAUGHER, S.</au><au>AKHLAGHI, S.</au><au>JACK, D. B.</au><au>KENDALL, M. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of metoprolol</atitle><jtitle>Alimentary pharmacology &amp; therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>1988-12</date><risdate>1988</risdate><volume>2</volume><issue>6</issue><spage>521</spage><epage>527</epage><pages>521-527</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>SUMMARY The impact of cimetidine, ranitidine and placebo on the pharmacokinetics of metoprolol, given either as a single dose (100 mg) or for 7 days (100 mg b.d.), has been evaluated in two separate studies. The doses used were 800 mg cimetidine daily and 300 mg ranitidine daily. The subjects were all young, healthy volunteers. In the single dose study, cimetidine produced a marked increase in the peak plasma concentration of metoprolol and in the area under the plasma concentration‐time curve; ranitidine had less effect, though the area under the curve was significantly greater than placebo. In the chronic dosing study, the area under the curve for metoprolol was also significantly higher on cimetidine (1796 ng h/ml; P &lt; 0.001) whereas the area under the curve on ranitidine (1258 ng h/ml) was comparable to that on placebo (1183 ng h/ml). Despite these drug‐induced changes in plasma metoprolol concentration, neither cimetidine nor ranitidine altered the change in exercise‐induced heart rate during dosing with metoprolol.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2979275</pmid><doi>10.1111/j.1365-2036.1988.tb00726.x</doi><tpages>7</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0269-2813
ispartof Alimentary pharmacology & therapeutics, 1988-12, Vol.2 (6), p.521-527
issn 0269-2813
1365-2036
language eng
recordid cdi_proquest_miscellaneous_78827133
source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Adult
Cimetidine - pharmacology
Female
Humans
Male
Metoprolol - pharmacokinetics
Ranitidine - pharmacology
Single-Blind Method
title The effects of ranitidine and cimetidine on the pharmacokinetics and pharmacodynamics of metoprolol
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T23%3A56%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effects%20of%20ranitidine%20and%20cimetidine%20on%20the%20pharmacokinetics%20and%20pharmacodynamics%20of%20metoprolol&rft.jtitle=Alimentary%20pharmacology%20&%20therapeutics&rft.au=CHELLINGSWORTH,%20M.%20C.&rft.date=1988-12&rft.volume=2&rft.issue=6&rft.spage=521&rft.epage=527&rft.pages=521-527&rft.issn=0269-2813&rft.eissn=1365-2036&rft_id=info:doi/10.1111/j.1365-2036.1988.tb00726.x&rft_dat=%3Cproquest_cross%3E78827133%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78827133&rft_id=info:pmid/2979275&rfr_iscdi=true