Nuclease stability as dominant factor in the antiviral activity of oligonucleotides directed against HSV-1 IE110

The anti-herpes simplex virus type 1 (anti-HSV-1) efficacy of a series of oligonucleotides was determined as a function of their chemical structure. All oligonucleotides consisted of the same sequence directed against the translation initiation codon of the HSV-1 immediate early gene. The oligonucle...

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Veröffentlicht in:	Antiviral research 1997, Vol.33 (2), p.135-139
Hauptverfasser:	Peyman, Anusch, Helsberg, Matthias, Kretzschmar, Gerhard, Mag, Matthias, Ryte, Antonina, Uhlmann, Eugen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antisense Antiviral agents Antiviral Agents - pharmacology Biological and medical sciences Cercopithecus aethiops Deoxyribonucleases - metabolism Herpes simplex virus Herpesvirus 1, Human - drug effects Humans Medical sciences Nuclease resistance Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - pharmacology Oligonucleotide inhibition Partial modification Pharmacology. Drug treatments Protection pattern Structure-Activity Relationship Vero Cells
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