Pentoxifylline improves survival following hemorrhagic shock
Pentoxifylline is an agent which improves microcirculatory blood flow, but its use as therapy for shock has not been reported. We performed this study to determine if pentoxifylline improves survival following experimental hemorrhagic shock. Anesthetized Sprague-Dawley rats were studied; the animals...
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| Veröffentlicht in: | Critical care medicine 1989-01, Vol.17 (1), p.36-47 |
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| container_title | Critical care medicine |
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| creator | COCCIA, MICHAEL T WAXMAN, KENNETH SOLIMAN, M HANI TOMINAGA, GAIL PINDERSKI, LAURA |
| description | Pentoxifylline is an agent which improves microcirculatory blood flow, but its use as therapy for shock has not been reported. We performed this study to determine if pentoxifylline improves survival following experimental hemorrhagic shock. Anesthetized Sprague-Dawley rats were studied; the animals were subjected to hemorrhage and then resuscitated using lactated Ringerʼs solution, with either placebo or pentoxifylline added by random selecting. Animals were then observed for 3 days. There was significantly increased survival in pentoxifylline-treated animals (p < .05). In additional experiments, animals received more aggressive fluid resuscitation; improved survival in the pentoxifylline group was noted almost immediately and persisted through the 72-h period. This was significant at the p < .01 level. We conclude that pentoxifylline improves survival from hemorrhagic shock in this experimental model, and has additive survival value to fluid resuscitation. |
| doi_str_mv | 10.1097/00003246-198901000-00009 |
| format | Article |
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We performed this study to determine if pentoxifylline improves survival following experimental hemorrhagic shock. Anesthetized Sprague-Dawley rats were studied; the animals were subjected to hemorrhage and then resuscitated using lactated Ringerʼs solution, with either placebo or pentoxifylline added by random selecting. Animals were then observed for 3 days. There was significantly increased survival in pentoxifylline-treated animals (p < .05). In additional experiments, animals received more aggressive fluid resuscitation; improved survival in the pentoxifylline group was noted almost immediately and persisted through the 72-h period. This was significant at the p < .01 level. We conclude that pentoxifylline improves survival from hemorrhagic shock in this experimental model, and has additive survival value to fluid resuscitation.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/00003246-198901000-00009</identifier><identifier>PMID: 2909319</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: Williams & Wilkins</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Biological and medical sciences ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care ; Fluid Therapy ; Intensive care medicine ; Male ; Medical sciences ; Pentoxifylline - therapeutic use ; Rats ; Rats, Inbred Strains ; Shock, Hemorrhagic - drug therapy ; Theobromine - analogs & derivatives</subject><ispartof>Critical care medicine, 1989-01, Vol.17 (1), p.36-47</ispartof><rights>Williams & Wilkins 1989. All Rights Reserved.</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3849-4b0a8982c7bd5f45363d7115bda858557d18718e58b422f772a4c6c2360064963</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7084852$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2909319$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>COCCIA, MICHAEL T</creatorcontrib><creatorcontrib>WAXMAN, KENNETH</creatorcontrib><creatorcontrib>SOLIMAN, M HANI</creatorcontrib><creatorcontrib>TOMINAGA, GAIL</creatorcontrib><creatorcontrib>PINDERSKI, LAURA</creatorcontrib><title>Pentoxifylline improves survival following hemorrhagic shock</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>Pentoxifylline is an agent which improves microcirculatory blood flow, but its use as therapy for shock has not been reported. We performed this study to determine if pentoxifylline improves survival following experimental hemorrhagic shock. Anesthetized Sprague-Dawley rats were studied; the animals were subjected to hemorrhage and then resuscitated using lactated Ringerʼs solution, with either placebo or pentoxifylline added by random selecting. Animals were then observed for 3 days. There was significantly increased survival in pentoxifylline-treated animals (p < .05). In additional experiments, animals received more aggressive fluid resuscitation; improved survival in the pentoxifylline group was noted almost immediately and persisted through the 72-h period. This was significant at the p < .01 level. We conclude that pentoxifylline improves survival from hemorrhagic shock in this experimental model, and has additive survival value to fluid resuscitation.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</subject><subject>Fluid Therapy</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pentoxifylline - therapeutic use</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Shock, Hemorrhagic - drug therapy</subject><subject>Theobromine - analogs & derivatives</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctOwzAQRS0EglL4BKQsELuAn7EtsUEVL6kSLGBtOY7TmDpxsZsW_p6Ulu7wxpp7z8xY1wBkCF4jKPkNHA7BtMiRFBKioco3kjwAI8TIUGBJDsFoUGBOqCQn4DSlDwgRZZwcg2MsoSRIjsDtq-2W4cvV3967zmauXcSwsilLfVy5lfZZHbwPa9fNssa2IcZGz5zJUhPM_Awc1done767x-D94f5t8pRPXx6fJ3fT3BBBZU5LqIUU2PCyYjVlpCAVR4iVlRZMMMYrJDgSlomSYlxzjjU1hcGkgLCgsiBjcLWdO7zts7dpqVqXjPVedzb0SXEhMBVCDqDYgiaGlKKt1SK6VsdvhaDaBKf-glP74H6lTevFbkdftrbaN-6SGvzLna-T0b6OujMu7TEOBRUMDxjdYuvglzamue_XNqrGar9s1H_fRn4ASiWD_g</recordid><startdate>198901</startdate><enddate>198901</enddate><creator>COCCIA, MICHAEL T</creator><creator>WAXMAN, KENNETH</creator><creator>SOLIMAN, M HANI</creator><creator>TOMINAGA, GAIL</creator><creator>PINDERSKI, LAURA</creator><general>Williams & Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198901</creationdate><title>Pentoxifylline improves survival following hemorrhagic shock</title><author>COCCIA, MICHAEL T ; WAXMAN, KENNETH ; SOLIMAN, M HANI ; TOMINAGA, GAIL ; PINDERSKI, LAURA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3849-4b0a8982c7bd5f45363d7115bda858557d18718e58b422f772a4c6c2360064963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</topic><topic>Fluid Therapy</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pentoxifylline - therapeutic use</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Shock, Hemorrhagic - drug therapy</topic><topic>Theobromine - analogs & derivatives</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>COCCIA, MICHAEL T</creatorcontrib><creatorcontrib>WAXMAN, KENNETH</creatorcontrib><creatorcontrib>SOLIMAN, M HANI</creatorcontrib><creatorcontrib>TOMINAGA, GAIL</creatorcontrib><creatorcontrib>PINDERSKI, LAURA</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>COCCIA, MICHAEL T</au><au>WAXMAN, KENNETH</au><au>SOLIMAN, M HANI</au><au>TOMINAGA, GAIL</au><au>PINDERSKI, LAURA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pentoxifylline improves survival following hemorrhagic shock</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>1989-01</date><risdate>1989</risdate><volume>17</volume><issue>1</issue><spage>36</spage><epage>47</epage><pages>36-47</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>Pentoxifylline is an agent which improves microcirculatory blood flow, but its use as therapy for shock has not been reported. We performed this study to determine if pentoxifylline improves survival following experimental hemorrhagic shock. Anesthetized Sprague-Dawley rats were studied; the animals were subjected to hemorrhage and then resuscitated using lactated Ringerʼs solution, with either placebo or pentoxifylline added by random selecting. Animals were then observed for 3 days. There was significantly increased survival in pentoxifylline-treated animals (p < .05). In additional experiments, animals received more aggressive fluid resuscitation; improved survival in the pentoxifylline group was noted almost immediately and persisted through the 72-h period. This was significant at the p < .01 level. We conclude that pentoxifylline improves survival from hemorrhagic shock in this experimental model, and has additive survival value to fluid resuscitation.</abstract><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>2909319</pmid><doi>10.1097/00003246-198901000-00009</doi><tpages>12</tpages></addata></record> |
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| identifier | ISSN: 0090-3493 |
| ispartof | Critical care medicine, 1989-01, Vol.17 (1), p.36-47 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Fluid Therapy Intensive care medicine Male Medical sciences Pentoxifylline - therapeutic use Rats Rats, Inbred Strains Shock, Hemorrhagic - drug therapy Theobromine - analogs & derivatives |
| title | Pentoxifylline improves survival following hemorrhagic shock |
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