The combination of amoxicillin-clavulanic acid and ofloxacin in the treatment of multidrug-resistant Mycobacterium tuberculosis
A 67-year-old [correction of 53] man with multidrug resistant tuberculosis (MDR-TB) had been persistently positive for acid-fast bacilli (AFB) both on sputum smear and also on culture with the Ogawa egg medium for 30 years since 1951. The case had been treated previously with isoniazid, rifampin, st...
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| Veröffentlicht in: | Kekkaku 1997-01, Vol.72 (1), p.9-13 |
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| creator | Iwanaga, T Yokota, K Kishikawa, R Ikeda, T Tsurutani, H Hirose, T Nishima, S |
| description | A 67-year-old [correction of 53] man with multidrug resistant tuberculosis (MDR-TB) had been persistently positive for acid-fast bacilli (AFB) both on sputum smear and also on culture with the Ogawa egg medium for 30 years since 1951. The case had been treated previously with isoniazid, rifampin, streptomycin, ethambutol, kanamycin, ethionamide, paraaminosalicylate and cycloserine; however, M. tuberculosis strains isolated from this patient acquired a high resistance to all of these agents. Then, a new regimen of chemotherapy, INH combined with ofloxacin (OFLX) and amoxicillin-clavulanic acid (AMPC/ CVA), was applied to the case. He was successfully treated with this regimen, and a marked decrease in the amount of AFB on smear as well as on culture was observed during the course of chemotherapy. No adverse effects were seen meanwhile. These data suggest that it is worth while to try a regimen containing AMPC/CVA and OFLX in the treatment of MDR-TB. |
| doi_str_mv | 10.11400/kekkaku1923.72.9 |
| format | Article |
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The case had been treated previously with isoniazid, rifampin, streptomycin, ethambutol, kanamycin, ethionamide, paraaminosalicylate and cycloserine; however, M. tuberculosis strains isolated from this patient acquired a high resistance to all of these agents. Then, a new regimen of chemotherapy, INH combined with ofloxacin (OFLX) and amoxicillin-clavulanic acid (AMPC/ CVA), was applied to the case. He was successfully treated with this regimen, and a marked decrease in the amount of AFB on smear as well as on culture was observed during the course of chemotherapy. No adverse effects were seen meanwhile. 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These data suggest that it is worth while to try a regimen containing AMPC/CVA and OFLX in the treatment of MDR-TB.</description><subject>Aged</subject><subject>Amoxicillin - administration & dosage</subject><subject>Amoxicillin-Potassium Clavulanate Combination</subject><subject>Antitubercular Agents - administration & dosage</subject><subject>Clavulanic Acids - administration & dosage</subject><subject>Drug Administration Schedule</subject><subject>Drug Therapy, Combination - administration & dosage</subject><subject>Humans</subject><subject>Isoniazid - administration & dosage</subject><subject>Male</subject><subject>Ofloxacin - administration & dosage</subject><subject>Tuberculosis, Multidrug-Resistant - drug therapy</subject><subject>Tuberculosis, Pulmonary - drug therapy</subject><issn>0022-9776</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkMtOwzAQRb0Alar0A1ggZcUuxa_E9RJVvKQiNmUdTWwHTOy4JDZqV_w6RlQa6Whm7r3SDEJXBK8I4Rjf9qbvoU9EUrYSdCXP0BxjSkspRH2BltNkW4yx5Jit-QzNZCYmeI5-dh-mUMG3doBow1CErgAfDlZZ5-xQKgffycFgVQHK6gIGnSUuHHI3FLli9sfRQPRmiH9un1y0ekzv5WgmO0XI45ejCi2oaEabfBFTa0aVXMjrS3TegZvM8sQFenu4322eyu3r4_Pmblt-Uo5jqaWsOQECDJioGNOkNrrihDPcSoo57UglW52xpkYZApQJwTFnDKq6w4wt0M1_7n4MX8lMsfF2Usbl00xIUyPWa8pFjl6g65Mwtd7oZj9aD-OxOX2M_QKBrXAM</recordid><startdate>199701</startdate><enddate>199701</enddate><creator>Iwanaga, T</creator><creator>Yokota, K</creator><creator>Kishikawa, R</creator><creator>Ikeda, T</creator><creator>Tsurutani, H</creator><creator>Hirose, T</creator><creator>Nishima, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199701</creationdate><title>The combination of amoxicillin-clavulanic acid and ofloxacin in the treatment of multidrug-resistant Mycobacterium tuberculosis</title><author>Iwanaga, T ; Yokota, K ; Kishikawa, R ; Ikeda, T ; Tsurutani, H ; Hirose, T ; Nishima, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j240t-d99641a1a3a37533d16ed541430b92042f159bd2f182ece1a237740433a56f033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1997</creationdate><topic>Aged</topic><topic>Amoxicillin - administration & dosage</topic><topic>Amoxicillin-Potassium Clavulanate Combination</topic><topic>Antitubercular Agents - administration & dosage</topic><topic>Clavulanic Acids - administration & dosage</topic><topic>Drug Administration Schedule</topic><topic>Drug Therapy, Combination - administration & dosage</topic><topic>Humans</topic><topic>Isoniazid - administration & dosage</topic><topic>Male</topic><topic>Ofloxacin - administration & dosage</topic><topic>Tuberculosis, Multidrug-Resistant - drug therapy</topic><topic>Tuberculosis, Pulmonary - drug therapy</topic><toplevel>online_resources</toplevel><creatorcontrib>Iwanaga, T</creatorcontrib><creatorcontrib>Yokota, K</creatorcontrib><creatorcontrib>Kishikawa, R</creatorcontrib><creatorcontrib>Ikeda, T</creatorcontrib><creatorcontrib>Tsurutani, H</creatorcontrib><creatorcontrib>Hirose, T</creatorcontrib><creatorcontrib>Nishima, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Kekkaku</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Iwanaga, T</au><au>Yokota, K</au><au>Kishikawa, R</au><au>Ikeda, T</au><au>Tsurutani, H</au><au>Hirose, T</au><au>Nishima, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The combination of amoxicillin-clavulanic acid and ofloxacin in the treatment of multidrug-resistant Mycobacterium tuberculosis</atitle><jtitle>Kekkaku</jtitle><addtitle>Kekkaku</addtitle><date>1997-01</date><risdate>1997</risdate><volume>72</volume><issue>1</issue><spage>9</spage><epage>13</epage><pages>9-13</pages><issn>0022-9776</issn><abstract>A 67-year-old [correction of 53] man with multidrug resistant tuberculosis (MDR-TB) had been persistently positive for acid-fast bacilli (AFB) both on sputum smear and also on culture with the Ogawa egg medium for 30 years since 1951. 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| subjects | Aged Amoxicillin - administration & dosage Amoxicillin-Potassium Clavulanate Combination Antitubercular Agents - administration & dosage Clavulanic Acids - administration & dosage Drug Administration Schedule Drug Therapy, Combination - administration & dosage Humans Isoniazid - administration & dosage Male Ofloxacin - administration & dosage Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Pulmonary - drug therapy |
| title | The combination of amoxicillin-clavulanic acid and ofloxacin in the treatment of multidrug-resistant Mycobacterium tuberculosis |
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