Suppression of SPARC expression by antisense RNA abrogates the tumorigenicity of human melanoma cells

Acquisition of invasive/metastatic potential is a key event in tumor progression. Cell surface glycoproteins and their respective matrix ligands have been implicated in this process. Recent evidence reveals that the secreted glycoprotein SPARC (secreted protein, acidic and rich in cysteine) is highl...

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Veröffentlicht in:	Nature medicine 1997-02, Vol.3 (2), p.171-176
Hauptverfasser:	Ledda, M. Fernanda, Adris, Soraya, Bravo, Alicia I., Kairiyama, Claudia, Bover, Laura, Chernajovsky, Yuti, Mordoh, Jose, Podhajcer, Osvaldo L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Cancer Research Cell Adhesion - genetics Cell Division - genetics Cell Movement - genetics Down-Regulation Gene Expression Regulation, Neoplastic Humans Infectious Diseases Melanoma - genetics Melanoma - pathology Melanoma, Experimental - genetics Melanoma, Experimental - pathology Metabolic Diseases Mice Molecular Medicine Neurosciences Oligonucleotides, Antisense - genetics Osteonectin - genetics Transfection Tumor Cells, Cultured
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