Reduction of I(Ca,L) and I(to1) density in hypertrophied right ventricular cells by simulated high altitude in adult rats

The present paper describes the effect of a simulated hypobaric condition (at the altitude of 4500 m) on morphological characteristics and on some ionic currents in ventricular cells of adult rats. According to current data, chronic high-altitude exposure led to mild right ventricular hypertrophy. I...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 1997-01, Vol.29 (1), p.193-206
Hauptverfasser:	Chouabe, C, Espinosa, L, Megas, P, Chakir, A, Rougier, O, Freminet, A, Bonvallet, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Adaptation, Physiological Altitude Animals Calcium Channels - physiology Computer Simulation Hypertrophy, Right Ventricular - pathology Hypertrophy, Right Ventricular - physiopathology In Vitro Techniques Male Patch-Clamp Techniques Potassium Channels - drug effects Potassium Channels - physiology Rats Rats, Sprague-Dawley Reference Values Space life sciences Tetraethylammonium Tetraethylammonium Compounds - pharmacology
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