Longitudinal changes in regional cerebral blood flow in a normal elderly group

Longitudinal changes in regional cerebral blood flow in a normal elderly group

Only one published study to date has examined longitudinal age-changes in regional cerebral blood flow (rCBF) in an elderly group. It found rCBF declined significantly in their elderly sample over a 24 to 42 month period. The current study attempts to cross-validate the earlier study's findings...

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Veröffentlicht in:Archives of clinical neuropsychology 1989, Vol.4 (3), p.217-226
Hauptverfasser: Maclnnes, William D., Paull, Dana, Quaife, Merton
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Sprache:eng
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Biological and medical sciences
Development. Metamorphosis. Moult. Ageing
Fundamental and applied biological sciences. Psychology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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container_title Archives of clinical neuropsychology
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creator Maclnnes, William D.
Paull, Dana
Quaife, Merton
description Only one published study to date has examined longitudinal age-changes in regional cerebral blood flow (rCBF) in an elderly group. It found rCBF declined significantly in their elderly sample over a 24 to 42 month period. The current study attempts to cross-validate the earlier study's findings with an older normal elderly group and a longer time interval between rCBF studies. This study is consistent with that investigation. The normal elderly did exhibit significant declines in blood flow across a variety of indices including: gray and white matter and the Initial Slope Index. These declines were generally on the order of .50 to .75 of a standard deviation loss. No significant differences in blood flow decline between males and females were discerned. While the young-old did exhibit greater blood flow than the old-old there were no significant differences in the rate of decline between the two age-groups.
doi_str_mv 10.1016/0887-6177(89)90014-0
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subjects Biological and medical sciences
Development. Metamorphosis. Moult. Ageing
Fundamental and applied biological sciences. Psychology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
title Longitudinal changes in regional cerebral blood flow in a normal elderly group
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