Tumor growth, weight loss and cytokines in SCID mice
It has been proposed that immunoregulatory cytokines play a role in the onset and development of cancer cachexia, although evidence supporting this theory remains inconclusive. In the present study, SCID mice were implanted with one of two tumor cell lines known to induce weight loss in rats. Growth...
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| Veröffentlicht in: | Cancer letters 1997, Vol.111 (1), p.111-115 |
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| container_title | Cancer letters |
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| creator | Murray, Susan Schell, Kathleen McCarthy, Donna O. Albertini, Mark R. |
| description | It has been proposed that immunoregulatory cytokines play a role in the onset and development of cancer cachexia, although evidence supporting this theory remains inconclusive. In the present study, SCID mice were implanted with one of two tumor cell lines known to induce weight loss in rats. Growth of the Morris 7777 hepatoma was associated with weight loss as well as increased levels of tumor necrosis factor and interleukins 1 and 6 in spleen cells of tumor-bearing mice. Growth of the MCA sarcoma did not induce weight loss, nor did it increase cytokine expression in spleen cells of tumor-bearing mice. We conclude that increased cytokine expression is associated with weight loss in tumor-bearing SCID mice, and immune activation for cytokine expression does not require the presence of T or B cells. |
| doi_str_mv | 10.1016/S0304-3835(96)04519-3 |
| format | Article |
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In the present study, SCID mice were implanted with one of two tumor cell lines known to induce weight loss in rats. Growth of the Morris 7777 hepatoma was associated with weight loss as well as increased levels of tumor necrosis factor and interleukins 1 and 6 in spleen cells of tumor-bearing mice. Growth of the MCA sarcoma did not induce weight loss, nor did it increase cytokine expression in spleen cells of tumor-bearing mice. 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In the present study, SCID mice were implanted with one of two tumor cell lines known to induce weight loss in rats. Growth of the Morris 7777 hepatoma was associated with weight loss as well as increased levels of tumor necrosis factor and interleukins 1 and 6 in spleen cells of tumor-bearing mice. Growth of the MCA sarcoma did not induce weight loss, nor did it increase cytokine expression in spleen cells of tumor-bearing mice. We conclude that increased cytokine expression is associated with weight loss in tumor-bearing SCID mice, and immune activation for cytokine expression does not require the presence of T or B cells.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cytokines</subject><subject>General aspects (metabolism, cell proliferation, established cell line...)</subject><subject>Interleukin-1 - metabolism</subject><subject>Interleukin-6 - metabolism</subject><subject>Liver Neoplasms, Experimental - metabolism</subject><subject>Liver Neoplasms, Experimental - pathology</subject><subject>Liver Neoplasms, Experimental - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, SCID</subject><subject>Neoplasm Proteins - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred BUF</subject><subject>Sarcoma, Experimental - metabolism</subject><subject>Sarcoma, Experimental - pathology</subject><subject>Sarcoma, Experimental - physiopathology</subject><subject>SCID/scid mice</subject><subject>Species Specificity</subject><subject>Tumor cell</subject><subject>Tumor growth</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Tumors</subject><subject>Weight loss</subject><subject>Weight Loss - physiology</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PGzEQhq2qiAban4C0h6oqUpeOx-u1fUJVaEukSBygZ8uxZ8GwH9TegPLvWUiUK6c5vM87M3oYO-FwxoHXP69BQFUKLeR3U59CJbkpxQc241phqYyGj2y2Rz6xo5zvAUBWSh6yQwOIXMgZq27W3ZCK2zQ8j3c_imeKt3dj0Q45F64Phd-Mw0PsKRexL67ni4uii54-s4PGtZm-7OYx-_fn9838slxe_V3Mfy1LL7QZS1SNJy9cU6NuoEIjAB3wEFa4kkhIKtR6JaRqAkdOxvNKIOiaEMEYDOKYfdvufUzD_zXl0XYxe2pb19OwzlZpjdwoOYFyC_o0fZ6osY8pdi5tLAf7asu-2bKvKqyp7ZstK6beye7AetVR2Ld2eqb86y532bu2Sa73Me8xlBqUMhN2vsVokvEUKdnsI_WeQkzkRxuG-M4jL0xfg98</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Murray, Susan</creator><creator>Schell, Kathleen</creator><creator>McCarthy, Donna O.</creator><creator>Albertini, Mark R.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Tumor growth, weight loss and cytokines in SCID mice</title><author>Murray, Susan ; Schell, Kathleen ; McCarthy, Donna O. ; Albertini, Mark R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-27fcec3af628f0429302a01ddb2b52e2e7d68b357fd121e9c1432086e220992d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cytokines</topic><topic>General aspects (metabolism, cell proliferation, established cell line...)</topic><topic>Interleukin-1 - metabolism</topic><topic>Interleukin-6 - metabolism</topic><topic>Liver Neoplasms, Experimental - metabolism</topic><topic>Liver Neoplasms, Experimental - pathology</topic><topic>Liver Neoplasms, Experimental - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, SCID</topic><topic>Neoplasm Proteins - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred BUF</topic><topic>Sarcoma, Experimental - metabolism</topic><topic>Sarcoma, Experimental - pathology</topic><topic>Sarcoma, Experimental - physiopathology</topic><topic>SCID/scid mice</topic><topic>Species Specificity</topic><topic>Tumor cell</topic><topic>Tumor growth</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Tumors</topic><topic>Weight loss</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murray, Susan</creatorcontrib><creatorcontrib>Schell, Kathleen</creatorcontrib><creatorcontrib>McCarthy, Donna O.</creatorcontrib><creatorcontrib>Albertini, Mark R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murray, Susan</au><au>Schell, Kathleen</au><au>McCarthy, Donna O.</au><au>Albertini, Mark R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor growth, weight loss and cytokines in SCID mice</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1997</date><risdate>1997</risdate><volume>111</volume><issue>1</issue><spage>111</spage><epage>115</epage><pages>111-115</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>It has been proposed that immunoregulatory cytokines play a role in the onset and development of cancer cachexia, although evidence supporting this theory remains inconclusive. In the present study, SCID mice were implanted with one of two tumor cell lines known to induce weight loss in rats. Growth of the Morris 7777 hepatoma was associated with weight loss as well as increased levels of tumor necrosis factor and interleukins 1 and 6 in spleen cells of tumor-bearing mice. Growth of the MCA sarcoma did not induce weight loss, nor did it increase cytokine expression in spleen cells of tumor-bearing mice. We conclude that increased cytokine expression is associated with weight loss in tumor-bearing SCID mice, and immune activation for cytokine expression does not require the presence of T or B cells.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9022135</pmid><doi>10.1016/S0304-3835(96)04519-3</doi><tpages>5</tpages></addata></record> |
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| ispartof | Cancer letters, 1997, Vol.111 (1), p.111-115 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Cytokines General aspects (metabolism, cell proliferation, established cell line...) Interleukin-1 - metabolism Interleukin-6 - metabolism Liver Neoplasms, Experimental - metabolism Liver Neoplasms, Experimental - pathology Liver Neoplasms, Experimental - physiopathology Male Medical sciences Mice Mice, SCID Neoplasm Proteins - metabolism Rats Rats, Inbred BUF Sarcoma, Experimental - metabolism Sarcoma, Experimental - pathology Sarcoma, Experimental - physiopathology SCID/scid mice Species Specificity Tumor cell Tumor growth Tumor Necrosis Factor-alpha - metabolism Tumors Weight loss Weight Loss - physiology |
| title | Tumor growth, weight loss and cytokines in SCID mice |
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