Naloxone‐sensitive, haloperidol‐sensitive, [3H] (+) SKF‐10047‐binding protein partially purified from rat liver and rat brain membranes: An opioid/sigma receptor?

A naloxone‐sensitive, haloperidol‐sensitive, [3H](+)SKF‐10047‐binding protein was partially purified from rat liver and rat brain membranes in an affinity chromatography originally designed to purify sigma receptors. Detergent‐solubilized extracts from membranes were adsorbed to Sephadex G‐25 resin...

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Veröffentlicht in:	Synapse (New York, N.Y.) N.Y.), 1997-02, Vol.25 (2), p.117-124
Hauptverfasser:	Tsao, Li‐i, Su, Tsung‐Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	affinity chromatography Animals Antipsychotic Agents - pharmacology Brain - metabolism haloperidol Haloperidol - pharmacology Liver - metabolism naloxone Naloxone - pharmacology N‐allyl‐normetazocine opioid receptor Phenazocine - analogs & derivatives Phenazocine - pharmacology protein Radioligand Assay rat brain rat liver Rats Receptors, Opioid - drug effects sigma opioid receptor sigma receptor SKF‐10047
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