Selective Loss of Hippocampal Granule Cells in the Mature Rat Brain after Adrenalectomy
Adrenalectomy of adult male rats resulted in a nearly complete loss of hippocampal granule cells 3 to 4 months after surgery. Nissl and immunocytochemical staining of hippocampal neurons revealed that the granule cell loss was selective; there was no apparent loss of hippocampal pyramidal cells or o...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1989-01, Vol.243 (4890), p.535-538 |
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| creator | Sloviter, Robert S. Valiquette, Guy Abrams, Gary M. Ronk, Edward C. Sollas, Anne L. Paul, Linda A. Neubort, Simon |
| description | Adrenalectomy of adult male rats resulted in a nearly complete loss of hippocampal granule cells 3 to 4 months after surgery. Nissl and immunocytochemical staining of hippocampal neurons revealed that the granule cell loss was selective; there was no apparent loss of hippocampal pyramidal cells or of γ-amino butyric acid (GABA)--, somatostatin-, neuropeptide Y--, calcium binding protein--, or parvalbumin-containing hippocampal interneurons. The hippocampal CA1 pyramidal cells of adrenalectomized animals exhibited normal electrophysiological responses to afferent stimulation, whereas responses evoked in the dentate gyrus were severely attenuated. Corticosterone replacement prevented both the adrenalectomy-induced granule cell loss and the attenuated physiological response. Thus, the adrenal glands play a role in maintaining the structural integrity of the normal adult brain. |
| doi_str_mv | 10.1126/science.2911756 |
| format | Article |
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Nissl and immunocytochemical staining of hippocampal neurons revealed that the granule cell loss was selective; there was no apparent loss of hippocampal pyramidal cells or of γ-amino butyric acid (GABA)--, somatostatin-, neuropeptide Y--, calcium binding protein--, or parvalbumin-containing hippocampal interneurons. The hippocampal CA1 pyramidal cells of adrenalectomized animals exhibited normal electrophysiological responses to afferent stimulation, whereas responses evoked in the dentate gyrus were severely attenuated. Corticosterone replacement prevented both the adrenalectomy-induced granule cell loss and the attenuated physiological response. Thus, the adrenal glands play a role in maintaining the structural integrity of the normal adult brain.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.2911756</identifier><identifier>PMID: 2911756</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Adrenal glands ; Adrenalectomy ; Animals ; Annexin A6 ; Biological and medical sciences ; Brain ; Calcium-Binding Proteins - analysis ; Cellular immunity ; Corticosterone ; Corticosterone - pharmacology ; Cytoplasmic Granules ; Electrophysiology ; Evoked Potentials ; Fundamental and applied biological sciences. Psychology ; Hippocampus ; Hippocampus (Brain) ; Hippocampus - cytology ; Hippocampus - drug effects ; Hippocampus - physiology ; Hormones ; Immunohistochemistry ; Isolated neuron and nerve. Neuroglia ; Laboratory rats ; Male ; Neurobiology ; Neurons ; Neurons - cytology ; Neurons - physiology ; Physiological aspects ; Potassium ; Potassium - blood ; Pyramidal cells ; Rats ; Rats as laboratory animals ; Sodium ; Sodium - blood ; Vertebrates: nervous system and sense organs ; Weight Gain</subject><ispartof>Science (American Association for the Advancement of Science), 1989-01, Vol.243 (4890), p.535-538</ispartof><rights>Copyright 1989 The American Association for the Advancement of Science</rights><rights>1989 INIST-CNRS</rights><rights>COPYRIGHT 1989 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1989 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jan 27, 1989</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c795t-fdbcec780a7d6b39b1a4b06f985bdf409f690bc356596e82ec20cbbf19c05fa83</citedby><cites>FETCH-LOGICAL-c795t-fdbcec780a7d6b39b1a4b06f985bdf409f690bc356596e82ec20cbbf19c05fa83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1703224$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1703224$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7277790$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2911756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sloviter, Robert S.</creatorcontrib><creatorcontrib>Valiquette, Guy</creatorcontrib><creatorcontrib>Abrams, Gary M.</creatorcontrib><creatorcontrib>Ronk, Edward C.</creatorcontrib><creatorcontrib>Sollas, Anne L.</creatorcontrib><creatorcontrib>Paul, Linda A.</creatorcontrib><creatorcontrib>Neubort, Simon</creatorcontrib><title>Selective Loss of Hippocampal Granule Cells in the Mature Rat Brain after Adrenalectomy</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Adrenalectomy of adult male rats resulted in a nearly complete loss of hippocampal granule cells 3 to 4 months after surgery. Nissl and immunocytochemical staining of hippocampal neurons revealed that the granule cell loss was selective; there was no apparent loss of hippocampal pyramidal cells or of γ-amino butyric acid (GABA)--, somatostatin-, neuropeptide Y--, calcium binding protein--, or parvalbumin-containing hippocampal interneurons. The hippocampal CA1 pyramidal cells of adrenalectomized animals exhibited normal electrophysiological responses to afferent stimulation, whereas responses evoked in the dentate gyrus were severely attenuated. Corticosterone replacement prevented both the adrenalectomy-induced granule cell loss and the attenuated physiological response. Thus, the adrenal glands play a role in maintaining the structural integrity of the normal adult brain.</description><subject>Adrenal glands</subject><subject>Adrenalectomy</subject><subject>Animals</subject><subject>Annexin A6</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Calcium-Binding Proteins - analysis</subject><subject>Cellular immunity</subject><subject>Corticosterone</subject><subject>Corticosterone - pharmacology</subject><subject>Cytoplasmic Granules</subject><subject>Electrophysiology</subject><subject>Evoked Potentials</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus</subject><subject>Hippocampus (Brain)</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>Hormones</subject><subject>Immunohistochemistry</subject><subject>Isolated neuron and nerve. Neuroglia</subject><subject>Laboratory rats</subject><subject>Male</subject><subject>Neurobiology</subject><subject>Neurons</subject><subject>Neurons - cytology</subject><subject>Neurons - physiology</subject><subject>Physiological aspects</subject><subject>Potassium</subject><subject>Potassium - blood</subject><subject>Pyramidal cells</subject><subject>Rats</subject><subject>Rats as laboratory animals</subject><subject>Sodium</subject><subject>Sodium - blood</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Weight Gain</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN082LEzEUAPAgylqrZy8KYRE9rLObjyaZHLtFuwvVguvHcchkXuqU-ajJjLj_vSkddlcptOQQyPvlJby8IPSSknNKmbwItoTGwjnTlCohH6ERJVokmhH-GI0I4TJJiRJP0bMQ1oTEmOYn6GTgI_TjBiqwXfkb8KINAbcOX5WbTWtNvTEVnnvT9BXgGVRVwGWDu5-AP5mu94C_mA5fehMXjevA42nhoTHbbG19-xw9caYK8GKYx-jbxw9fZ1fJYjm_nk0XiVVadIkrcgtWpcSoQuZc59RMciKdTkVeuAnRTmqSWy6k0BJSBpYRm-eOakuEMykfo7e7vBvf_uohdFldBhtvaxpo-5CpNGVEEXEQcsk4ESk5CFmsnNLk8NFUUK7lREZ4-h9ct72Ppdom44JrGqcxOtuhVSxhVjau7byxK2jAm6ptwJVxeaoI0xO-veT7PTqOAurS7uHv_uFRdPCnW5k-hOz65vOxcvn9WHk5P1Km88VDebZP2raqYAVZ7JzZ8qG-2GnrY-t6cNnGl7Xxtxkl2fZ3ZMPvyIZ2jzteDy_R5zUUd_4-_maIm2BN5WL32zLcMcXU9ukje7Vj69C1_v5URThjE_4XioUcpw</recordid><startdate>19890127</startdate><enddate>19890127</enddate><creator>Sloviter, Robert S.</creator><creator>Valiquette, Guy</creator><creator>Abrams, Gary M.</creator><creator>Ronk, Edward C.</creator><creator>Sollas, Anne L.</creator><creator>Paul, Linda A.</creator><creator>Neubort, Simon</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19890127</creationdate><title>Selective Loss of Hippocampal Granule Cells in the Mature Rat Brain after Adrenalectomy</title><author>Sloviter, Robert S. ; Valiquette, Guy ; Abrams, Gary M. ; Ronk, Edward C. ; Sollas, Anne L. ; Paul, Linda A. ; Neubort, Simon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c795t-fdbcec780a7d6b39b1a4b06f985bdf409f690bc356596e82ec20cbbf19c05fa83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adrenal glands</topic><topic>Adrenalectomy</topic><topic>Animals</topic><topic>Annexin A6</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Calcium-Binding Proteins - analysis</topic><topic>Cellular immunity</topic><topic>Corticosterone</topic><topic>Corticosterone - pharmacology</topic><topic>Cytoplasmic Granules</topic><topic>Electrophysiology</topic><topic>Evoked Potentials</topic><topic>Fundamental and applied biological sciences. 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Simon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective Loss of Hippocampal Granule Cells in the Mature Rat Brain after Adrenalectomy</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1989-01-27</date><risdate>1989</risdate><volume>243</volume><issue>4890</issue><spage>535</spage><epage>538</epage><pages>535-538</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Adrenalectomy of adult male rats resulted in a nearly complete loss of hippocampal granule cells 3 to 4 months after surgery. Nissl and immunocytochemical staining of hippocampal neurons revealed that the granule cell loss was selective; there was no apparent loss of hippocampal pyramidal cells or of γ-amino butyric acid (GABA)--, somatostatin-, neuropeptide Y--, calcium binding protein--, or parvalbumin-containing hippocampal interneurons. The hippocampal CA1 pyramidal cells of adrenalectomized animals exhibited normal electrophysiological responses to afferent stimulation, whereas responses evoked in the dentate gyrus were severely attenuated. Corticosterone replacement prevented both the adrenalectomy-induced granule cell loss and the attenuated physiological response. Thus, the adrenal glands play a role in maintaining the structural integrity of the normal adult brain.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>2911756</pmid><doi>10.1126/science.2911756</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1989-01, Vol.243 (4890), p.535-538 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Adrenal glands Adrenalectomy Animals Annexin A6 Biological and medical sciences Brain Calcium-Binding Proteins - analysis Cellular immunity Corticosterone Corticosterone - pharmacology Cytoplasmic Granules Electrophysiology Evoked Potentials Fundamental and applied biological sciences. Psychology Hippocampus Hippocampus (Brain) Hippocampus - cytology Hippocampus - drug effects Hippocampus - physiology Hormones Immunohistochemistry Isolated neuron and nerve. Neuroglia Laboratory rats Male Neurobiology Neurons Neurons - cytology Neurons - physiology Physiological aspects Potassium Potassium - blood Pyramidal cells Rats Rats as laboratory animals Sodium Sodium - blood Vertebrates: nervous system and sense organs Weight Gain |
| title | Selective Loss of Hippocampal Granule Cells in the Mature Rat Brain after Adrenalectomy |
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