Clonal expansion within the CD4+CD57+ and CD8+CD57+ T cell subsets in chronic lymphocytic leukemia

The role of T cells in chronic lymphocytic leukemia (CLL) has not been extensively investigated, since the most prominent cellular abnormality in CLL involves the clonal expansion of B cells. In this study we have undertaken a comprehensive analysis of the CD4+ and CD8+ T cell repertoire in a popula...

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Veröffentlicht in:	The Journal of immunology (1950) 1997-02, Vol.158 (3), p.1482-1489
Hauptverfasser:	Serrano, D, Monteiro, J, Allen, SL, Kolitz, J, Schulman, P, Lichtman, SM, Buchbinder, A, Vinciguerra, VP, Chiorazzi, N, Gregersen, PK
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged AIDS/HIV Amino Acid Sequence Base Sequence CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology CD57 Antigens - analysis CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Clone Cells Female Humans Leukemia, Lymphocytic, Chronic, B-Cell - pathology Male Middle Aged Molecular Sequence Data Receptors, Antigen, T-Cell, alpha-beta - genetics RNA, Messenger - genetics T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - pathology
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