Bleomycin congeners exhibiting altered DNA cleavage specificity

The bleomycins (BLM's) are a family of structurally complex glycoprotein antibiotics possessing significant anticancer activity. Reported herein is an analysis of DNA cleavage by seven BLM congeners that establishes the existence of significant differences in the patterns of DNA cleavage. This...

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Veröffentlicht in:	Chemical research in toxicology 1988-01, Vol.1 (1), p.25-27
Hauptverfasser:	Shipley, Joshua B, Hecht, Sidney M
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Composition Bleomycin - pharmacology DNA - drug effects DNA - metabolism Molecular Structure Structure-Activity Relationship
Online-Zugang:	Volltext
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