Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds

The DNA alkylation and sequence specificity of a group of natural and synthetic pyrrolo-[1,4]benzodiazepines [P(1,4)Bs] were evaluated by using an exonuclease III stop assay, and the results were compared with in vitro and in vivo biological potency and antitumor activity. The P(1,4)B antibiotics ar...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical research in toxicology 1988-09, Vol.1 (5), p.258-268
Hauptverfasser:	Hurley, Laurence H, Reck, Teri, Thurston, David E, Langley, David R, Holden, Kenneth G, Hertzberg, Robert P, Hoover, John R. E, Gallagher, Gregory, Faucette, Leo F
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - metabolism Antibiotics, Antineoplastic - pharmacology Base Sequence Benzodiazepines - chemistry Benzodiazepines - metabolism Benzodiazepines - pharmacology Binding Sites DNA - chemistry DNA - metabolism Molecular Sequence Data Pyrroles - chemistry Pyrroles - metabolism Pyrroles - pharmacology Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!