Doppler sonography evaluation of superior mesenteric artery flow to assess Crohn's disease activity: correlation with clinical evaluation, Crohn's disease activity index, and alpha 1-antitrypsin clearance in feces
This study was undertaken to investigate the value of Doppler flow measurements of the superior mesenteric artery (SMA) as a marker for disease activity in patients with Crohn's disease. Duplex Doppler sonography measurements of SMA blood flow volume were obtained in 29 consecutive patients wit...
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| Veröffentlicht in: | American journal of roentgenology (1976) 1997-02, Vol.168 (2), p.429-433 |
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| container_title | American journal of roentgenology (1976) |
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| creator | van Oostayen, JA Wasser, MN van Hogezand, RA Griffioen, G Biemond, I Lamers, CB de Roos, A |
| description | This study was undertaken to investigate the value of Doppler flow measurements of the superior mesenteric artery (SMA) as a marker for disease activity in patients with Crohn's disease.
Duplex Doppler sonography measurements of SMA blood flow volume were obtained in 29 consecutive patients with suspected Crohn's disease. We prospectively sought a correlation between the independent assessment of Doppler flow measurements and markers for disease activity: Crohn's disease activity index and fecal alpha 1-antitrypsin clearance and our reference standard based on clinical history, physical examination, laboratory values, endoscopy, surgery, and follow-up.
In 27 of 29 patients, adequate measurements of SMA blood flow were obtained. In 15 patients no disease activity was judged to be present or no Crohn's disease (n = 2) was found at follow-up (group 1). In 12 patients, activity of Crohn's disease was diagnosed (group 2) on the basis of the reference standard. In group 2 the Doppler SMA blood flow values were significantly higher (p < .05) than those for group 1 (826 +/- 407 ml/min versus 323 +/- 103 ml/min). Of the other parameters investigated, only the alpha 1-antitrypsin value correlated with the reference standard but to a lesser degree than the values for SMA blood flow measurement.
This prospective study shows that SMA Doppler blood flow measurements can be used to assess disease activity in patients with Crohn's disease. This approach may be of value in the diagnosis and follow-up of patients with Crohn's disease, providing directly available, quantifiable, noninvasive information on disease activity. |
| doi_str_mv | 10.2214/ajr.168.2.9016220 |
| format | Article |
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Duplex Doppler sonography measurements of SMA blood flow volume were obtained in 29 consecutive patients with suspected Crohn's disease. We prospectively sought a correlation between the independent assessment of Doppler flow measurements and markers for disease activity: Crohn's disease activity index and fecal alpha 1-antitrypsin clearance and our reference standard based on clinical history, physical examination, laboratory values, endoscopy, surgery, and follow-up.
In 27 of 29 patients, adequate measurements of SMA blood flow were obtained. In 15 patients no disease activity was judged to be present or no Crohn's disease (n = 2) was found at follow-up (group 1). In 12 patients, activity of Crohn's disease was diagnosed (group 2) on the basis of the reference standard. In group 2 the Doppler SMA blood flow values were significantly higher (p < .05) than those for group 1 (826 +/- 407 ml/min versus 323 +/- 103 ml/min). Of the other parameters investigated, only the alpha 1-antitrypsin value correlated with the reference standard but to a lesser degree than the values for SMA blood flow measurement.
This prospective study shows that SMA Doppler blood flow measurements can be used to assess disease activity in patients with Crohn's disease. This approach may be of value in the diagnosis and follow-up of patients with Crohn's disease, providing directly available, quantifiable, noninvasive information on disease activity.</description><identifier>ISSN: 0361-803X</identifier><identifier>EISSN: 1546-3141</identifier><identifier>DOI: 10.2214/ajr.168.2.9016220</identifier><identifier>PMID: 9016220</identifier><language>eng</language><publisher>United States: Am Roentgen Ray Soc</publisher><subject>Adult ; alpha 1-Antitrypsin - analysis ; Crohn Disease - diagnosis ; Crohn Disease - diagnostic imaging ; Crohn Disease - physiopathology ; Feces - chemistry ; Female ; Humans ; Male ; Mesenteric Artery, Superior - diagnostic imaging ; Prospective Studies ; Severity of Illness Index ; Splanchnic Circulation - physiology ; Ultrasonography, Doppler</subject><ispartof>American journal of roentgenology (1976), 1997-02, Vol.168 (2), p.429-433</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1740-e08edca569a448373165689ce3d75541de045afb0e449f16b7414052395e3e9f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4106,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9016220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Oostayen, JA</creatorcontrib><creatorcontrib>Wasser, MN</creatorcontrib><creatorcontrib>van Hogezand, RA</creatorcontrib><creatorcontrib>Griffioen, G</creatorcontrib><creatorcontrib>Biemond, I</creatorcontrib><creatorcontrib>Lamers, CB</creatorcontrib><creatorcontrib>de Roos, A</creatorcontrib><title>Doppler sonography evaluation of superior mesenteric artery flow to assess Crohn's disease activity: correlation with clinical evaluation, Crohn's disease activity index, and alpha 1-antitrypsin clearance in feces</title><title>American journal of roentgenology (1976)</title><addtitle>AJR Am J Roentgenol</addtitle><description>This study was undertaken to investigate the value of Doppler flow measurements of the superior mesenteric artery (SMA) as a marker for disease activity in patients with Crohn's disease.
Duplex Doppler sonography measurements of SMA blood flow volume were obtained in 29 consecutive patients with suspected Crohn's disease. We prospectively sought a correlation between the independent assessment of Doppler flow measurements and markers for disease activity: Crohn's disease activity index and fecal alpha 1-antitrypsin clearance and our reference standard based on clinical history, physical examination, laboratory values, endoscopy, surgery, and follow-up.
In 27 of 29 patients, adequate measurements of SMA blood flow were obtained. In 15 patients no disease activity was judged to be present or no Crohn's disease (n = 2) was found at follow-up (group 1). In 12 patients, activity of Crohn's disease was diagnosed (group 2) on the basis of the reference standard. In group 2 the Doppler SMA blood flow values were significantly higher (p < .05) than those for group 1 (826 +/- 407 ml/min versus 323 +/- 103 ml/min). Of the other parameters investigated, only the alpha 1-antitrypsin value correlated with the reference standard but to a lesser degree than the values for SMA blood flow measurement.
This prospective study shows that SMA Doppler blood flow measurements can be used to assess disease activity in patients with Crohn's disease. This approach may be of value in the diagnosis and follow-up of patients with Crohn's disease, providing directly available, quantifiable, noninvasive information on disease activity.</description><subject>Adult</subject><subject>alpha 1-Antitrypsin - analysis</subject><subject>Crohn Disease - diagnosis</subject><subject>Crohn Disease - diagnostic imaging</subject><subject>Crohn Disease - physiopathology</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mesenteric Artery, Superior - diagnostic imaging</subject><subject>Prospective Studies</subject><subject>Severity of Illness Index</subject><subject>Splanchnic Circulation - physiology</subject><subject>Ultrasonography, Doppler</subject><issn>0361-803X</issn><issn>1546-3141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcuO1DAQRS0EGpqBD2CB5BVsJo2d2HmwGzVPaSQ2ILGzqp3KxCO3HVzJhHwo_0NQR8CGVZVU555aXMaeS7HPc6lew13ay7Le5_tGyDLPxQO2k1qVWSGVfMh2oihlVovi22P2hOhOCFHVTXXBLjZ8x36-jcPgMXGKId4mGPqF4z34CUYXA48dp2nA5GLiJyQM47pbDmmdC-98nPkYORAhET-k2IdXxFtHCIQc7Oju3bi84TamhP6snN3Yc-tdcBb8P7-u_pvnLrT444pDaDn4oQcuMwijG9MykAurDCFBsLiCvEOL9JQ96sATPtvmJfv6_t2Xw8fs5vOHT4frm8zKSokMRY2tBV02oFRdVIUsdVk3Fou20lrJFoXS0B0FKtV0sjxWSiqh86LRWGDTFZfs5dk7pPh9QhrNyZFF7yFgnMhUdS11U-oVlGfQpkiUsDNDcidIi5HC_K7SrFWatUqTm62bNfNik0_HE7Z_En_v2_Pe3fazS2joBN6vtDTzPJ9lKm-KX4IXrQI</recordid><startdate>19970201</startdate><enddate>19970201</enddate><creator>van Oostayen, JA</creator><creator>Wasser, MN</creator><creator>van Hogezand, RA</creator><creator>Griffioen, G</creator><creator>Biemond, I</creator><creator>Lamers, CB</creator><creator>de Roos, A</creator><general>Am Roentgen Ray Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970201</creationdate><title>Doppler sonography evaluation of superior mesenteric artery flow to assess Crohn's disease activity: correlation with clinical evaluation, Crohn's disease activity index, and alpha 1-antitrypsin clearance in feces</title><author>van Oostayen, JA ; Wasser, MN ; van Hogezand, RA ; Griffioen, G ; Biemond, I ; Lamers, CB ; de Roos, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1740-e08edca569a448373165689ce3d75541de045afb0e449f16b7414052395e3e9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>alpha 1-Antitrypsin - analysis</topic><topic>Crohn Disease - diagnosis</topic><topic>Crohn Disease - diagnostic imaging</topic><topic>Crohn Disease - physiopathology</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mesenteric Artery, Superior - diagnostic imaging</topic><topic>Prospective Studies</topic><topic>Severity of Illness Index</topic><topic>Splanchnic Circulation - physiology</topic><topic>Ultrasonography, Doppler</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Oostayen, JA</creatorcontrib><creatorcontrib>Wasser, MN</creatorcontrib><creatorcontrib>van Hogezand, RA</creatorcontrib><creatorcontrib>Griffioen, G</creatorcontrib><creatorcontrib>Biemond, I</creatorcontrib><creatorcontrib>Lamers, CB</creatorcontrib><creatorcontrib>de Roos, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of roentgenology (1976)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Oostayen, JA</au><au>Wasser, MN</au><au>van Hogezand, RA</au><au>Griffioen, G</au><au>Biemond, I</au><au>Lamers, CB</au><au>de Roos, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Doppler sonography evaluation of superior mesenteric artery flow to assess Crohn's disease activity: correlation with clinical evaluation, Crohn's disease activity index, and alpha 1-antitrypsin clearance in feces</atitle><jtitle>American journal of roentgenology (1976)</jtitle><addtitle>AJR Am J Roentgenol</addtitle><date>1997-02-01</date><risdate>1997</risdate><volume>168</volume><issue>2</issue><spage>429</spage><epage>433</epage><pages>429-433</pages><issn>0361-803X</issn><eissn>1546-3141</eissn><abstract>This study was undertaken to investigate the value of Doppler flow measurements of the superior mesenteric artery (SMA) as a marker for disease activity in patients with Crohn's disease.
Duplex Doppler sonography measurements of SMA blood flow volume were obtained in 29 consecutive patients with suspected Crohn's disease. We prospectively sought a correlation between the independent assessment of Doppler flow measurements and markers for disease activity: Crohn's disease activity index and fecal alpha 1-antitrypsin clearance and our reference standard based on clinical history, physical examination, laboratory values, endoscopy, surgery, and follow-up.
In 27 of 29 patients, adequate measurements of SMA blood flow were obtained. In 15 patients no disease activity was judged to be present or no Crohn's disease (n = 2) was found at follow-up (group 1). In 12 patients, activity of Crohn's disease was diagnosed (group 2) on the basis of the reference standard. In group 2 the Doppler SMA blood flow values were significantly higher (p < .05) than those for group 1 (826 +/- 407 ml/min versus 323 +/- 103 ml/min). Of the other parameters investigated, only the alpha 1-antitrypsin value correlated with the reference standard but to a lesser degree than the values for SMA blood flow measurement.
This prospective study shows that SMA Doppler blood flow measurements can be used to assess disease activity in patients with Crohn's disease. This approach may be of value in the diagnosis and follow-up of patients with Crohn's disease, providing directly available, quantifiable, noninvasive information on disease activity.</abstract><cop>United States</cop><pub>Am Roentgen Ray Soc</pub><pmid>9016220</pmid><doi>10.2214/ajr.168.2.9016220</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0361-803X |
| ispartof | American journal of roentgenology (1976), 1997-02, Vol.168 (2), p.429-433 |
| issn | 0361-803X 1546-3141 |
| language | eng |
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| source | American Roentgen Ray Society; MEDLINE; Alma/SFX Local Collection |
| subjects | Adult alpha 1-Antitrypsin - analysis Crohn Disease - diagnosis Crohn Disease - diagnostic imaging Crohn Disease - physiopathology Feces - chemistry Female Humans Male Mesenteric Artery, Superior - diagnostic imaging Prospective Studies Severity of Illness Index Splanchnic Circulation - physiology Ultrasonography, Doppler |
| title | Doppler sonography evaluation of superior mesenteric artery flow to assess Crohn's disease activity: correlation with clinical evaluation, Crohn's disease activity index, and alpha 1-antitrypsin clearance in feces |
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