Regulation of hypoxic gene expression in yeast
Regulation of hypoxic gene expression in yeast. Baker's yeast, Saccharomyces cerevisiae, can adapt to growth under severe oxygen limitation. Two regulatory systems are described here that control this adaptation. The first involves a heme-dependent repression mechanism. Cells sense hypoxia thro...
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| Veröffentlicht in: | Kidney international 1997-02, Vol.51 (2), p.507-513 |
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| creator | Zitomer, Rrichard S. Carrico, Pauline Deckert, Jutta |
| description | Regulation of hypoxic gene expression in yeast. Baker's yeast, Saccharomyces cerevisiae, can adapt to growth under severe oxygen limitation. Two regulatory systems are described here that control this adaptation. The first involves a heme-dependent repression mechanism. Cells sense hypoxia through the inability to maintain oxygen-dependent heme biosynthesis. Under aerobic conditions, heme accumulates and serves as an effector for the transcriptional activator Hapl. The heme-Hapl complex activates transcription of the ROX1 gene that encodes a repressor of one set of hypoxic genes. Under hypoxic conditions, heme levels fall, and a heme-deficient Hapl complex represses ROX1 expression. As a consequence, the hypoxic genes are derepressed. The second regulatory system activates gene expression in response to a variety of stress conditions, including oxygen limitation. Oxygen sensing in this system is heme-independent. The same DNA sequence mediates transcriptional activation of each stress signal |
| doi_str_mv | 10.1038/ki.1997.71 |
| format | Article |
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Baker's yeast, Saccharomyces cerevisiae, can adapt to growth under severe oxygen limitation. Two regulatory systems are described here that control this adaptation. The first involves a heme-dependent repression mechanism. Cells sense hypoxia through the inability to maintain oxygen-dependent heme biosynthesis. Under aerobic conditions, heme accumulates and serves as an effector for the transcriptional activator Hapl. The heme-Hapl complex activates transcription of the ROX1 gene that encodes a repressor of one set of hypoxic genes. Under hypoxic conditions, heme levels fall, and a heme-deficient Hapl complex represses ROX1 expression. As a consequence, the hypoxic genes are derepressed. The second regulatory system activates gene expression in response to a variety of stress conditions, including oxygen limitation. Oxygen sensing in this system is heme-independent. 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Baker's yeast, Saccharomyces cerevisiae, can adapt to growth under severe oxygen limitation. Two regulatory systems are described here that control this adaptation. The first involves a heme-dependent repression mechanism. Cells sense hypoxia through the inability to maintain oxygen-dependent heme biosynthesis. Under aerobic conditions, heme accumulates and serves as an effector for the transcriptional activator Hapl. The heme-Hapl complex activates transcription of the ROX1 gene that encodes a repressor of one set of hypoxic genes. Under hypoxic conditions, heme levels fall, and a heme-deficient Hapl complex represses ROX1 expression. As a consequence, the hypoxic genes are derepressed. The second regulatory system activates gene expression in response to a variety of stress conditions, including oxygen limitation. Oxygen sensing in this system is heme-independent. The same DNA sequence mediates transcriptional activation of each stress signal</description><subject>Base Sequence</subject><subject>Binding Sites</subject><subject>Consensus Sequence</subject><subject>DNA, Fungal - genetics</subject><subject>DNA, Fungal - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>DNA-Binding Proteins - metabolism</subject><subject>Fungal Proteins - genetics</subject><subject>Gene Expression Regulation, Fungal</subject><subject>Genes, Fungal</subject><subject>Heme - metabolism</subject><subject>Mediator Complex</subject><subject>Oxygen - metabolism</subject><subject>Repressor Proteins - genetics</subject><subject>Repressor Proteins - metabolism</subject><subject>RNA Polymerase II - genetics</subject><subject>RNA Polymerase II - metabolism</subject><subject>RNA, Fungal - genetics</subject><subject>RNA, Fungal - metabolism</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Saccharomyces cerevisiae Proteins</subject><subject>Transcription Factors - genetics</subject><subject>Transcription Factors - metabolism</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM1LwzAYxoMoc04v3oWePAit-Wia5ChjfsBAED2HNH0747qmJq1s_70dG548vTz8fjzwPghdE5wRzOT92mVEKZEJcoKmhFOWEsH5KZpiLHlKOZPn6CLGLzxmxfAETRSmQjAyRdkbrIbG9M63ia-Tz13nt84mK2ghgW0XIMY9cm2yAxP7S3RWmybC1fHO0Mfj4n3-nC5fn17mD8vU5lT1KYOSGwpVzQtc5jkVrBLKUguK5bWpJS5kUdqSQF7jQlSUW6GULXFVcFBclmyGbg-9XfDfA8Reb1y00DSmBT9ELaQkuSj4KN4dRBt8jAFq3QW3MWGnCdb7cfTa6f04WpBRvjm2DuUGqj_1uMbI8wOH8bUfB0FH66C1ULkAtteVd__V_gIg7HCy</recordid><startdate>19970201</startdate><enddate>19970201</enddate><creator>Zitomer, Rrichard S.</creator><creator>Carrico, Pauline</creator><creator>Deckert, Jutta</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970201</creationdate><title>Regulation of hypoxic gene expression in yeast</title><author>Zitomer, Rrichard S. ; 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Baker's yeast, Saccharomyces cerevisiae, can adapt to growth under severe oxygen limitation. Two regulatory systems are described here that control this adaptation. The first involves a heme-dependent repression mechanism. Cells sense hypoxia through the inability to maintain oxygen-dependent heme biosynthesis. Under aerobic conditions, heme accumulates and serves as an effector for the transcriptional activator Hapl. The heme-Hapl complex activates transcription of the ROX1 gene that encodes a repressor of one set of hypoxic genes. Under hypoxic conditions, heme levels fall, and a heme-deficient Hapl complex represses ROX1 expression. As a consequence, the hypoxic genes are derepressed. The second regulatory system activates gene expression in response to a variety of stress conditions, including oxygen limitation. Oxygen sensing in this system is heme-independent. 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| identifier | ISSN: 0085-2538 |
| ispartof | Kidney international, 1997-02, Vol.51 (2), p.507-513 |
| issn | 0085-2538 1523-1755 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Base Sequence Binding Sites Consensus Sequence DNA, Fungal - genetics DNA, Fungal - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fungal Proteins - genetics Gene Expression Regulation, Fungal Genes, Fungal Heme - metabolism Mediator Complex Oxygen - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism RNA Polymerase II - genetics RNA Polymerase II - metabolism RNA, Fungal - genetics RNA, Fungal - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins Transcription Factors - genetics Transcription Factors - metabolism |
| title | Regulation of hypoxic gene expression in yeast |
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